Protective Effects ofLycium barbarumPolysaccharides on Testis Spermatogenic Injury Induced by Bisphenol A in Mice

Abstract

To observe the effects of Lycium barbarum polysaccharides (LBP) on testis spermatogenic injuries induced by Bisphenol A (BPA) in mice. BPA was subcutaneously injected into mice at a dose of 20 mg/kg body weight (BW) for 7 consecutive days. LBP was administered simultaneously with BPA by gavage daily at the dose of 50, 100, and 200 mg/kg BW for 7 days. After treatment, the weight and the histopathology changes of testis and epididymis were examined; the contents of T, LH, GnRH, antioxidant enzyme, and malondialdehyde (MDA) in serum were detected; proapoptotic protein Bax and antiapoptotic protein Bcl-2 were also detected by immunohistochemical method. Results showed that the weights of testis and epididymis were all increased after supplement with different dosages of LBP compared with BPA group, and the activities of SOD and GSH-Px were significantly increased in LBP groups, while MDA contents were gradually decreased. Moreover, the levels of T, LH, and GnRH were significantly elevated in serum treated with 100 mg/kg LBP. LBP also shows significant positive effects on the expression of Bcl-2/Bax in BPA treated mice. It is concluded that LBP may be one of the potential ingredients protecting the adult male animals from BPA induced reproductive damage.

Semen quality improvement in boars fed with supplemental wolfberry (Lycium barbarum)

“…In this study, Experiment 1 was divided into four phases, with 40 days in each. The improvement of sperm quality in Phases II and III in the wolfberry group suggests that wolfberry may be beneficial for both the testis and epididymis, as has been speculated previously (Luo et al, ; Zhang et al, ). It should be noted that the progressive motility of sperm decreased during Phase IV compared to Phases II and III in both groups.…”

“…Lycium barbarum polysaccharide (LBP), which is considered a major antioxidant agent in wolfberry, exhibits multiple health‐beneficial biological activities, including antiaging, anticancer, hepatoprotective, immune enhancing, and therapeutic effects on the male reproductive system, etc (Cheng et al, ). Previous studies found significant protective effects of LBP on reproductive damage induced by irradiation or toxic reagents in rodents (Luo et al, , ; Qian & Yu, ; Shi et al, ; Zhang et al, ). For example, LBP exhibited profound protective effects on spermatogenic injury induced by bisphenol A in mice (Zhang et al, ), and ionizing irradiation in rats (Luo et al, ).…”

“…Previous studies found significant protective effects of LBP on reproductive damage induced by irradiation or toxic reagents in rodents (Luo et al, , ; Qian & Yu, ; Shi et al, ; Zhang et al, ). For example, LBP exhibited profound protective effects on spermatogenic injury induced by bisphenol A in mice (Zhang et al, ), and ionizing irradiation in rats (Luo et al, ). Luo et al () revealed that LBP significantly increased sperm quantity and motility, and improved the sexual ability of rats induced by 60 Co‐γ irradiation.…”

Protective effects of <i>Lycium barbarum</i> polysaccharide on male sexual dysfunction and fertility impairments by activating hypothalamic pituitary gonadal axis in streptozotocin-induced type-1 diabetic male mice

“…One of the Gouqi's main active ingredient is Lycium barbarum polysaccharide (LBP), which have shown multiple pharmacological activities such as hypolipidemic, antioxidant, anti-aging, antitumor, and immunomodulation et al [27,28]. A wide array of studies confirmed that sexual functionality, sperm quality as well as the serum endocrine hormone levels were significant improved after administration of LBP in rat in the following reproductive damage models such as corticosterone-induced inhibition of the sexual behavior [29], radiation-induced spermatogenic damage [30] and bisphenol A-induced testis spermatogenic injuries [31]. Based on the above considerations, we hypothesized that LBP might minimize fertility impairment in secondary complications of diabetes.…”

Can Goji Berry Extract Attenuate Pancreatic Structural Changes Induced by Patulin Toxin in Male Albino Rats?

“…Since LB reduced the number of caspase-3 positive cells in both acini and islets of Langerhans, this suggests its antiapoptotic activity. A number of studies had found that LB can increase the expression of Bcl-2 and decrease the expression of Bax and increase the ratio of Bcl-2/Bax [38] . It was proved that LB could inhibit Jun N-terminal kinases pathway which activate apoptotic signaling by the upregulation of pro-apoptotic genes [39] .…”