Protective Effects of L-2-Oxothiazolidine-4-Carboxylate during Isoproterenol-Induced Myocardial Infarction in Rats: In Vivo Study

Angelovski, Marija; Hadzi‐Petrushev, Nikola; Atanasov, D; Nikodinovski, Aleksandar; Mitrokhin, Vadim; Avtanski, Dimiter; Mladenov, Mitko

doi:10.3390/life12101466

Cited by 5 publications

(2 citation statements)

References 43 publications

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“…These findings are suggestive of lesser damage of myocardium in the presence of citric acid. Many researchers support these findings 16,17 .…”

Section: Discussionmentioning

confidence: 86%

Histopathological Evaluation of Ameliorated Effect of Citric Acid on Infarcted Myocardium

Aziz¹,

Talha²,

Afzal³

et al. 2023

PJMHS

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The estimated disease burden of ischemic heart disease in Pakistan is in millions and discovery of cardioprotective agents of organic origin has great importance to decrease the financial burden on society. Objective: The study was designed to analyze and grade histopathological changes in experimental model of myocardial infarction. Study Design: This was an experimental randomized controlled trial. Place and Duration: The study was organized at King Edward Medical University and University of Veterinary and Animal Sciences, Lahore for a period of 180 days. Methodology: During initial 14 days, cont-group and Isopro-group were treated with 1 ml normal saline, while Citric-250 and Citric-500-group were treated with citric acid at 250 mg and 500 mg per-kg-body-weight respectively. Isoproterenol (85mg per-kg-body-weight) was injected subcutaneously for induction of acute myocardial infarction in all rabbits except for cont-group. Histopathological analysis was done, serum-C.K-M.B (creatine-kinase-M.B), serum-L.D.H (lactate-dehydrogenase) and cTn-I (cardiac.troponin-I) were recorded at the end of experiment. S.P.S.S software (statistical package for social sciences) was applied for statistically analyzed of data. Results: Isopro-group showed augmented odema, infiltration and necrosis in myocardium on histopathological study along with elevated level of C.K-M.B, L.D.H and cTn-I as compare to other group. Citric-250 and citric-500-group showed significant recovery with reduced odema, infiltration and necrosis in myocardium on histopathological analysis along with lesser values of C.K-M.B, L.D.H and cTn-I as compare to Isopro-group. Practical Implication: Consumption of citric acid protects from acute myocardial infarction. Conclusion: It is concluded that citric acid possesses strong cardioprotective potential. It reduces the myocardial injury during infarction in term of edema, infiltration and necrosis that help myocardium to survive during ischemic condition. Keywords: Citric acid, Isoproterenol, Formalin, cTn-I, Infiltration and Myocardial Infarction.

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“…These findings are suggestive of lesser damage of myocardium in the presence of citric acid. Many researchers support these findings 16,17 .…”

Section: Discussionmentioning

confidence: 86%

Histopathological Evaluation of Ameliorated Effect of Citric Acid on Infarcted Myocardium

Aziz¹,

Talha²,

Afzal³

et al. 2023

PJMHS

View full text Add to dashboard Cite

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“…Several human diseases, including aging, diabetes, neurodegeneration, and cancer, have been linked to oxidative stress as one of their most prominent causes [15,16]. THC may have the ability to prevent oxidation-related human diseases due to its significant antioxidant activity, which has already been demonstrated in many in vitro and in vivo settings [17].…”

Section: The Structural Feature Of Thc Associated With Its Antioxidan...mentioning

confidence: 99%

Positive Tetrahydrocurcumin-Associated Brain-Related Metabolomic Implications

et al. 2023

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Tetrahydrocurcumin (THC) is a metabolite of curcumin (CUR). It shares many of CUR’s beneficial biological activities in addition to being more water-soluble, chemically stable, and bioavailable compared to CUR. However, its mechanisms of action have not been fully elucidated. This paper addresses the preventive role of THC on various brain dysfunctions as well as its effects on brain redox processes, traumatic brain injury, ischemia-reperfusion injury, Alzheimer’s disease, and Parkinson’s disease in various animal or cell culture models. In addition to its strong antioxidant properties, the effects of THC on the reduction of amyloid β aggregates are also well documented. The therapeutic potential of THC to treat patterns of mitochondrial brain dysmorphic dysfunction is also addressed and thoroughly reviewed, as is evidence from experimental studies about the mechanism of mitochondrial failure during cerebral ischemia/reperfusion injury. THC treatment also results in a dose-dependent decrease in ERK-mediated phosphorylation of GRASP65, which prevents further compartmentalization of the Golgi apparatus. The PI3K/AKT signaling pathway is possibly the most involved mechanism in the anti-apoptotic effect of THC. Overall, studies in various animal models of different brain disorders suggest that THC can be used as a dietary supplement to protect against traumatic brain injury and even improve brain function in Alzheimer’s and Parkinson’s diseases. We suggest further preclinical studies be conducted to demonstrate the brain-protective, anti-amyloid, and anti-Parkinson effects of THC. Application of the methods used in the currently reviewed studies would be useful and should help define doses and methods of THC administration in different disease conditions.

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