Protective Effects of Luteolin on Diabetic Nephropathy in STZ‐Induced Diabetic Rats

Wang, Guo Guang; Lu, Xinli; Li, Wei; Zhang, Xue; Zhang, Cui

doi:10.1155/2011/323171

Cited by 140 publications

(112 citation statements)

References 47 publications

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“…Rutin pretreatment prevented cisplatin-induced deteriorative effects by reduction of increased oxidative stress as well as caspase-3, TNF-α and NFκB protein expression levels (Arjumand et al, 2011). The flavonoid luteolin has been also shown to possess direct antioxidant activity that involved changes in SOD activity, the malondialdehyde (MDA) content and expression of Heme Oxygenase-1 (HO-1) protein (Wang et al, 2011). OLE acted as a genoprotective and antioxidant agent against PM-induced toxicity.…”

Section: Discussionmentioning

confidence: 99%

Olive (Olea europaea L.) leaf extract counteracts genotoxicity and oxidative stress of permethrin in human lymphocytes

Türkez

Toğar

2011

J. Toxicol. Sci.

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-The aim of this study was to investigate the protective effects of olive leaf extract (OLE) on genotoxicity and oxidative damage in cultured human blood cells treated with permethrin (PM) in the presence of a rat liver S9 mix containing cytochrome P 450 enzymes. Anti-genotoxic activities of OLE were studied using sister chromatid exchange (SCE) and chromosome aberration (CA) tests and furthermore total antioxidant capacity (TAC) and total oxidative status (TOS) were examined to determine the oxidative damage. Our results clearly revealed that treatment with PM (200 mg/l) alone increased SCE and CA rates and TOS level, decreased TAC level in cultured human blood cells. The OLE alone at the all tested doses did not induce any significant changes in the genotoxicity endpoint. However OLE leads to increases of plasma TAC level in vitro. OLE starts showing this positive effect at 100 mg/l. The combined treatment showed significant improvements in cytogenetic and biochemical parameters tested. Moreover, this improvement was more pronounced in the group received the high dose of the OLE. It could be concluded that the ethanol extract of OLE induced its genoprotective effect via the increase in the antioxidant capacity, inhibition of oxidative stress and scavenging of free radicals.

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Section: Discussionmentioning

confidence: 99%

Olive (Olea europaea L.) leaf extract counteracts genotoxicity and oxidative stress of permethrin in human lymphocytes

Türkez

Toğar

2011

J. Toxicol. Sci.

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“…Luteolin at high concentrations (10-50 mM) was reported to inhibit the activation of LXRa/b by the agonist T0901317, and the expression of its target gene, ABCA1, in macrophages (115). Despite this apparent inhibitory effect on LXR activation observed in vitro, luteolin supplementation has been shown to increase HDL cholesterol in both ovariectomized mice (50 mg/kg daily for 12 wk) (116) and streptozotocin-induced type 1 diabetic rats (200 mg/kg for 8 wk) (117). Chrysin and wogonin are 2 flavones that have also been studied in macrophage cell lines.…”

Section: Flavonesmentioning

confidence: 99%

Effects of Dietary Flavonoids on Reverse Cholesterol Transport, HDL Metabolism, and HDL function

Millar

Duclos

Blesso

2017

Advances in Nutrition

153

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Strong experimental evidence confirms that HDL directly alleviates atherosclerosis. HDL particles display diverse atheroprotective functions in reverse cholesterol transport (RCT), antioxidant, anti-inflammatory, and antiapoptotic processes. In certain inflammatory disease states, however, HDL particles may become dysfunctional and proatherogenic. Flavonoids show the potential to improve HDL function through their welldocumented effects on cellular antioxidant status and inflammation. The aim of this review is to summarize the basic science and clinical research examining the effects of dietary flavonoids on RCT and HDL function. Based on preclinical studies that used cell culture and rodent models, it appears that many flavonoids (e.g., anthocyanidins, flavonols, and flavone subclasses) influence RCT and HDL function beyond simple HDL cholesterol concentration by regulating cellular cholesterol efflux from macrophages and hepatic paraoxonase 1 expression and activity. In clinical studies, dietary anthocyanin intake is associated with beneficial changes in serum biomarkers related to HDL function in a variety of human populations (e.g., in those who are hyperlipidemic, hypertensive, or diabetic), including increased HDL cholesterol concentration, as well as HDL antioxidant and cholesterol efflux capacities. However, clinical research on HDL functionality is lacking for some flavonoid subclasses (e.g., flavanols, flavones, flavanones, and isoflavones). Although there has been a tremendous effort to develop HDL-targeted drug therapies, more research is warranted on how the intake of foods or specific nutrients affects HDL function. Adv Nutr 2017;8:226-39.

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“…This is partly due to insufficient knowledge of the pathophysiology initiated by hyperglycemia, the resulting DN, and its detection at a late stage. Some of the most important events in the pathogenesis of hyperglycemia-induced renal injury and DN are oxidative stress, inflammation, and fibrosis (Kanwar et al, 2011;Wang et al, 2011). Current therapies directed to delaying the progression of DN include 1) intensive glycemic and optimal blood pressure control, 2) interruption of the renin-angiotensin system through the use of angiotensin-converting enzyme inhibitors and angiotensin type 1 receptor blockers, and 3) dietary modification, flavonoid administration, and cholesterol-lowering agents (Sharma et al, 2008;Balakumar et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Diabetes-Induced Renal Injury in Rats Is Attenuated by Suramin

Korrapati

Shaner²,

Neely³

et al. 2012

The Journal of Pharmacology and Experimental Therapeutics

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Progression of hyperglycemia-induced renal injury is a contributing factor for diabetic nephropathy (DN)-induced end-stage renal disease (ESRD), and development of novel therapeutic strategies that act early to prevent progression of DN and ESRD are important. We examined the efficacy and mechanism(s) of suramin on hyperglycemia-induced renal injury before development of overt histological damage. Two groups of male Sprague-Dawley rats received streptozotocin (STZ) and one group received saline. Three weeks later, one STZ group received suramin (10 mg/kg). All animals were euthanized 1 week later (4 weeks). Although there was a decrease in creatinine clearance between control and STZ Ϯ suramin rats, there was no difference in creatinine clearance between STZ rats Ϯ suramin intervention. Liquid chromatography-tandem mass spectroscopy-based analysis revealed increases in urinary proteins that are early indicators of DN (e.g., cystatin C, clusterin, cathepsin B, retinol binding protein 4, and peroxiredoxin-1) in the STZ group, which were blocked by suramin. Endothelial intracellular adhesion molecule-1 (ICAM-1) activation, leukocyte infiltration, and inflammation; transforming growth factor-␤1 (TGF-␤1) signaling; TGF-␤1/SMAD-3-activated fibrogenic markers fibronectin-1, ␣-smooth muscle actin, and collagen 1A2; activation of proinflammatory and profibrotic transcription factors nuclear factor-B (NF-B) and signal transducer and activator of transcription factor-3 (STAT-3), respectively, were all increased in STZ rats and suramin blocked these changes. In conclusion, delayed administration of suramin attenuated 1) urinary markers of DN, 2) inflammation by blocking NF-B activation and ICAM-1-mediated leukocyte infiltration, and 3) fibrosis by blocking STAT-3 and TGF-␤1/ SMAD-3 signaling. These results support the potential use of suramin in DN.

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Protective Effects of Luteolin on Diabetic Nephropathy in STZ‐Induced Diabetic Rats

Cited by 140 publications

References 47 publications

Olive (Olea europaea L.) leaf extract counteracts genotoxicity and oxidative stress of permethrin in human lymphocytes

Olive (Olea europaea L.) leaf extract counteracts genotoxicity and oxidative stress of permethrin in human lymphocytes

Effects of Dietary Flavonoids on Reverse Cholesterol Transport, HDL Metabolism, and HDL function

Diabetes-Induced Renal Injury in Rats Is Attenuated by Suramin

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