Protective effects of medicinal plant against diabetes induced cardiac disorder: A review

Shabab, Sadegh; Gholamnezhad, Zahra; Mahmoudabady, Maryam

doi:10.1016/j.jep.2020.113328

Cited by 59 publications

(49 citation statements)

References 158 publications

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“…Bax and cleaved caspase-3 are proapoptotic proteins. 30,31 The present data revealed that DHA notably induced the apoptosis of HTFs via the upregulation of Bax and cleaved caspase-3. Importantly, autophagy is necessary for the onset of apoptosis, which usually affects the progression of apoptosis.…”

supporting

confidence: 53%

Dihydroartemisinin Inhibits TGF-β-Induced Fibrosis in Human Tenon Fibroblasts via Inducing Autophagy

Wang

Song

Zhang

et al. 2021

DDDT

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Background The formation of hypertrophic scars (HS) can result in the failure of glaucoma surgery, and fibrosis is known to be closely associated with the progression of HS. Dihydroartemisinin (DHA) has been reported to inhibit the progression of fibrosis; however, whether DHA can alleviate the formation of HS remains unclear. Methods In the present study, in order to examine the effects of DHA on the progression of HS, human Tenon’s capsule fibroblasts (HTFs) were isolated from patients who underwent glaucoma surgery. In addition, Western blot analysis, microtubule associated protein 1 light chain 3 α staining and reverse transcription-quantitative PCR were performed to detect protein and mRNA expression levels in the HTFs, respectively. Cell proliferation was detected by Ki67 staining. Flow cytometry was used to examine apoptosis and reactive oxygen species (ROS) levels in the HTFs. Results The results revealed that TGF-β promoted the proliferation and fibrosis of HTFs; however, DHA significantly reversed the effects of TGF-β by increasing cell autophagy. In addition, DHA notably induced the apoptosis of TGF-β-stimulated HTFs by increasing the ROS levels, while these increases were partially reversed by 3-methyladenine. Furthermore, DHA notably increased the expression of microRNA (miR)-145-5p in HTFs in a dose-dependent manner. Conclusion The present study demonstrated that DHA inhibits the TGF-β-induced fibrosis of HTFs by inducing autophagy. These findings may aid in the development of novel agents for the prevention of the formation of HS following glaucoma surgery.

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supporting

confidence: 53%

Dihydroartemisinin Inhibits TGF-β-Induced Fibrosis in Human Tenon Fibroblasts via Inducing Autophagy

Wang

Song

Zhang

et al. 2021

DDDT

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“…Medicinal plants may be a therapeutic alternative since they have long been applied in the treatment of several diseases, showing important scientifically proven results in improving health condition in several diseases with low side effects and costs [ 20 ]. Considering the large consumption of plants and people’s adherence to their use as a therapeutic strategy, the relationship between oxidative stress and the development of DM2 and its complications [ 5 , 19 , 21 , 22 ], and the relevant antioxidant potential that EA-Aa previously demonstrated [ 11 ], we aimed to analyse its potential as a therapeutic strategy in the treatment of DM2 and its complications.…”

Section: Discussionmentioning

confidence: 99%

Hypoglycaemic and Antioxidant Properties of Acrocomia aculeata (Jacq.) Lodd Ex Mart. Extract Are Associated with Better Vascular Function of Type 2 Diabetic Rats

et al. 2021

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Oxidative stress is involved in the metabolic dysregulation of type 2 diabetes (DM2). Acrocomia aculeata (Aa) fruit pulp has been described for the treatment of several diseases, and recently we have proved that its leaves have phenolic compounds with a marked antioxidant effect. We aimed to assess whether they can improve metabolic, redox and vascular functions in DM2. Control Wistar (W-Ctrl) and non-obese type 2 diabetic Goto–Kakizaki (GK-Ctrl) rats were treated for 30 days with 200 mg.kg−1 aqueous extract of Aa (EA-Aa) (Wistar, W-EA-Aa/GK, GK-EA-Aa). EA-Aa was able to reduce fasting glycaemia and triglycerides of GK-EA-Aa by improving proteins related to glucose and lipid metabolism, such as GLUT-4, PPARγ, AMPK, and IR, when compared to GK-Ctrl. It also improved viability of 3T3-L1 pre-adipocytes exposed by H2O2. EA-Aa also increased the levels of catalase in the aorta and kidney, reduced oxidative stress and increased relaxation of the aorta in GK-treated rats in relation to GK-Ctrl, in addition to the protective effect against oxidative stress in HMVec-D cells. We proved the direct antioxidant potential of the chemical compounds of EA-Aa, the increase in antioxidant defences in a tissue-specific manner and hypoglycaemic properties, improving vascular function in type 2 diabetes. EA-Aa and its constituents may have a therapeutic potential for the treatment of DM2 complications.

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“…Many studies reflect that their biological properties, such as antioxidant, antitumor and antimicrobial activities, are related to different bioactive compounds, including phenolic compounds. Although some of their mechanisms of action are unknown, in many cases it has been shown that various natural phenolic compounds are related to bioactive properties, and this has aroused the interest of the scientific community [1]. Several medicinal plants are still used for therapeutic purposes, employed in different formulas (decoctions, infusions, ointments, etc.)…”

Section: Introductionmentioning

confidence: 99%

Plants of the Family Asteraceae: Evaluation of Biological Properties and Identification of Phenolic Compounds

Barral-Martinez

García-Oliveira

Núñez-Estévez

et al. 2021

The 1st International Electronic Conference on Chemical Sensors and Analytical Chemistry

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The present study focused on the biological analysis of five plants: Achillea millefolium, Arnica montana, Calendula officinalis, Chamaemelum nobile and Taraxacum officinale. The results indicated that A. montana extracts showed the highest content of phenolic compounds. Regarding the biological properties, A. millefolium had outstanding antioxidant activity, while C. officinalis had the highest rate of antimicrobial and antifungal activity. The anti-inflammatory and cytotoxic activities reflected that C. nobile showed the highest effect. In enzyme assays, C. nobile and C. officinalis extracts showed the highest inhibitory effects on acetylcholinesterase and butyrylcholinesterase enzymes. Overall, this study provides scientific evidence for the evaluation of the potential of medicinal plant extracts for the development of new products.

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Protective effects of medicinal plant against diabetes induced cardiac disorder: A review

Cited by 59 publications

References 158 publications

Dihydroartemisinin Inhibits TGF-β-Induced Fibrosis in Human Tenon Fibroblasts via Inducing Autophagy

Dihydroartemisinin Inhibits TGF-β-Induced Fibrosis in Human Tenon Fibroblasts via Inducing Autophagy

Hypoglycaemic and Antioxidant Properties of Acrocomia aculeata (Jacq.) Lodd Ex Mart. Extract Are Associated with Better Vascular Function of Type 2 Diabetic Rats

Plants of the Family Asteraceae: Evaluation of Biological Properties and Identification of Phenolic Compounds

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