Protective effects of melatonin and quercetin on experimental lung injury induced by carbon tetrachloride in rats

Taşlıdere, Elif; Eşrefoğlu, Mukaddes; Elbe, Hülya; Çetin, Aslı; Ateş, Burhan

doi:10.3109/01902148.2013.866181

Cited by 32 publications

(29 citation statements)

References 38 publications

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“…A melatonin deficiency may cause defective bone formation and favor excess fibrous tissue formation . In general, the findings are consistent with a protective action of melatonin against fibrosis , an action that involves all organs .…”

Section: Introductionsupporting

confidence: 78%

“…Herein, fibrosis is considered in its pathological form. Excessive fibrosis can be found in multiple organs including heart , liver , lung , kidney , and other organs and tissues ; it occurs as a final outcome of injury or failure. The common fibrotic pathogenesis is orchestrated by complex activities within a variety cells in which specific molecular pathways are activated .…”

Section: Introductionmentioning

confidence: 99%

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Melatonin: the dawning of a treatment for fibrosis?

Jiang

et al. 2016

Journal of Pineal Research

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Section: Introductionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Melatonin: the dawning of a treatment for fibrosis?

Jiang

et al. 2016

Journal of Pineal Research

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“…, cognitive disorders , learning and memory impairments , and anxiety disorders . Importantly, melatonin also attenuates hemorrhagic injury under different experimental conditions in various organs , including the brain . Previous studies concerning melatonin and SAH have focused on the roles of inflammatory response, reactive oxygen species (ROS) generation, and oxidative stress in the brain .…”

Section: Introductionmentioning

confidence: 99%

Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling

Dong

Fan

et al. 2016

Journal of Pineal Research

165

132

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Subarachnoid hemorrhage (SAH) is a devastating condition with high morbidity and mortality rates due to the lack of effective therapy. Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation associated with the upregulation of apoptotic signaling pathway has been implicated in various inflammatory diseases including hemorrhagic insults. Melatonin is reported to possess substantial anti-inflammatory properties, which is beneficial for early brain injury (EBI) after SAH. However, the molecular mechanisms have not been clearly identified. This study was designed to investigate the protective effects of melatonin against EBI induced by SAH and to elucidate the potential mechanisms. The adult mice were subjected to SAH. Melatonin or vehicle was injected intraperitoneally 2 hr after SAH. Melatonin was neuroprotective, as shown by increased survival rate, as well as elevated neurological score, greater survival of neurons, preserved brain glutathione levels, and reduced brain edema, malondialdehyde concentrations, apoptotic ratio, and blood-brain barrier (BBB) disruption. Melatonin also attenuated the expressions of NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), cleaved caspase-1, interleukin-1β (IL-1β), and interleukin-6 (IL-6); these changes were also associated with an increase in the anti-apoptotic factor (Bcl2) and reduction in the pro-apoptotic factor (Bim). In summary, our results demonstrate that melatonin treatment attenuates the EBI following SAH by inhibiting NLRP3 inflammasome-associated apoptosis.

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“…Treatment with melatonin or quercetin showed marked improvement of the alveoli and alveolar septae and a marked decrease of cellular infiltration, especially in rats that received a combination of melatonin and quercetin. This beneficial effect of both melatonin and quercetin was previously documented in animals that underwent experimental lung damage (31). Greater improvement of pathological changes is obvious in rats that received co-treatment of both drugs.…”

Section: Discussionmentioning

confidence: 61%

“…A previous study demonstrated that quercetin can elicit protective effects in different lung injury models (14,31). At the molecular level, quercetin inhibits pulmonary oxidant stress in lung epithelial cells through inducing heme oxygenase-1 (HO-1) and via modulating the expression of antioxidant genes (14).…”

mentioning

confidence: 99%

Pulmonary prophylactic impact of melatonin and/or quercetin: A novel therapy for inflammatory hypoxic stress in rats

et al. 2017

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The study aims to compare, through histological and biochemical studies, the effects of quercetin, melatonin and their combination in regulation of immuno-inflammatory mediators and heat shock protein expressions in sodium nitrite induced hypoxia in rat lungs. The results revealed that NaNO 2 injection caused a significant decrease in Hb in rats, while serum levels of TNF-a, IL-6 and CRP, VEGF and HSP70 were elevated compared to the control group. Administration of melatonin, quercetin or their combination before NaNO 2 injection markedly reduced these parameters. Histopathological examination of the lung tissue supported these biochemical findings. The study suggests that melatonin and/or quercetin are responsible for lung tissue protection in hypoxia by downregulation of immuno-inflammatory mediators and heat shock protein expressions. Pre-treatment of hypoxic animals with a combination of melatonin and quercetin was effective in modulating most of the studied parameters to near-normal levels.

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Protective effects of melatonin and quercetin on experimental lung injury induced by carbon tetrachloride in rats

Abstract: In conclusion, we suggest that agents with antioxidant properties such as melatonin and quercetin may have positive effects in the treatment of pulmonary diseases characterized by especially edema, inflammation, and fibrosis.

Cited by 32 publications

References 38 publications

Melatonin: the dawning of a treatment for fibrosis?

Melatonin: the dawning of a treatment for fibrosis?

Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling

Pulmonary prophylactic impact of melatonin and/or quercetin: A novel therapy for inflammatory hypoxic stress in rats

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