Protective Effects of Micronutrient Supplements, Phytochemicals and Phytochemical-Rich Beverages and Foods Against DNA Damage in Humans: A Systematic Review of Randomized Controlled Trials and Prospective Studies

Fenech, Michael; Bull, Caroline; Klinken, Jan-Willem van

doi:10.1016/j.advnut.2023.08.004

Cited by 17 publications

(7 citation statements)

References 176 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These damages included the frequency of MN in lymphocytes or oral mucosa. According to the results of the study, some nutrients demonstrated protective effects for adult individuals [ 14 ]. Also, a review of 21 studies suggested the clinical applicability of the MN test as a predictor of head and neck cancer [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…Currently, a series of systematic reviews have summarized the results of the effect of nutritional factors on the frequency of MN in adults [ 13 , 14 ], but until now, there is no knowledge that other reviews of the same type have described these results for the maternal and child population. Therefore, it is relevant to list the primary evidence for this audience.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of maternal diet on the frequency of micronuclei in pregnant women and newborns: A protocol for systematic review and meta-analysis

Araújo,

Medeiros,

Nascimento

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Background The effects of diet on maternal and child genetic levels have been previously reported. Diet-associated DNA damage, such as the presence of micronuclei (MN), may be related to an increased risk of developing chronic diseases, such as cancer. Such damage is particularly concerning during pregnancy as it can affect the newborn. Aim This review will aim to summarize the primary evidence of the impact of diet during pregnancy on micronucleus frequency in the maternal-newborn population. Methods This protocol was developed based on the Preferred Reporting Items guidelines for Systematic Reviews and Meta-analyses Protocol. The review was registered with the International Register of Prospective Systematic Reviews on February 17, 2022 (registration number: CRD42022302401). We will use PubMed, Embase, Web of Science, Scopus, Science direct, and Google databases to search for observational studies. This review will include studies that investigate the diet consumed by pregnant women and its effect on the frequency of MN in mothers and newborns without any time or language limitations. For data extraction, researchers will independently review the full text and collect information that characterizes the study and its findings. We will analyze the results by calculating the odds ratio for each type of diet evaluated, accompanied by a 95% confidence interval. We will perform a quantitative synthesis of homogeneous studies to perform a meta-analysis. Micronucleus frequency quantifies the effect and will be presented as the mean and standard deviation or median and interquartile range. Expected results This review will aim to identify which dietary patterns during pregnancy may be associated with an increase in the frequency of MN in mothers and their newborns. Understanding the impact of diet on the frequency of MN is essential to deepen studies and to propose strategies that aim to protect the health of the public through food.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of maternal diet on the frequency of micronuclei in pregnant women and newborns: A protocol for systematic review and meta-analysis

Araújo,

Medeiros,

Nascimento

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Antioxidants neutralize free radicals, which can inflict damage on cellular structures ( Halliwell, 1996 ), including DNA and telomeres. This protective effect can be essential in countering telomere shortening, and thereby possibly delaying cellular aging ( Fenech et al, 2023 ).…”

Section: Telomere-based Interventions: Current Market Landscape For L...mentioning

confidence: 99%

Unlocking longevity: the role of telomeres and its targeting interventions

Schellnegger,

Hofmann,

Carnieletto

et al. 2024

Front. Aging

View full text Add to dashboard Cite

Average life expectancy has been steadily increasing in developed countries worldwide. These demographic changes are associated with an ever-growing social and economic strain to healthcare systems as well as society. The aging process typically manifests as a decline in physiological and cognitive functions, accompanied by a rise in chronic diseases. Consequently, strategies that both mitigate age-related diseases and promote healthy aging are urgently needed. Telomere attrition, characterized by the shortening of telomeres with each cell division, paradoxically serves as both a protective mechanism and a contributor to tissue degeneration and age-related ailments. Based on the essential role of telomere biology in aging, research efforts aim to develop approaches designed to counteract telomere attrition, aiming to delay or reduce age-related diseases. In this review, telomere biology and its role in aging and age-related diseases is summarized along with recent approaches to interfere with telomere shortening aiming at well- and healthy-aging as well as longevity. As aging research enters a new era, this review emphasizes telomere-targeting therapeutics, including telomerase activators and tankyrase inhibitors, while also exploring the effects of antioxidative and anti-inflammatory agents, along with indirectly related approaches like statins.

show abstract

“…Increasing evidence has shown that circulating mtDNA can trigger innate immunity by activating the Toll-like receptor 9/NF-κB pathway [63] or the NOD, LRR, and pyrin domain-containing protein 3 (NLRP3) inflammasome [64]. Zinc, in conjunction with various micronutrients, plays a role in DNA metabolism, resulting in reduced DNA damage and lowered levels of mtDNA in the bloodstream [65]. Conversely, lower zinc concentrations have been correlated with higher levels of mtDNA in patients with HIV and those coinfected with HIV and hepatitis C [66].…”

Section: Immune Regulationmentioning

confidence: 99%

The Anti-Oxidative, Anti-Inflammatory, Anti-Apoptotic, and Anti-Necroptotic Role of Zinc in COVID-19 and Sepsis

Briassoulis,

Ilia

et al. 2023

Antioxidants

View full text Add to dashboard Cite

Zinc is a structural component of proteins, functions as a catalytic co-factor in DNA synthesis and transcription of hundreds of enzymes, and has a regulatory role in protein–DNA interactions of zinc-finger proteins. For many years, zinc has been acknowledged for its anti-oxidative and anti-inflammatory functions. Furthermore, zinc is a potent inhibitor of caspases-3, -7, and -8, modulating the caspase-controlled apoptosis and necroptosis. In recent years, the immunomodulatory role of zinc in sepsis and COVID-19 has been investigated. Both sepsis and COVID-19 are related to various regulated cell death (RCD) pathways, including apoptosis and necroptosis. Lack of zinc may have a negative effect on many immune functions, such as oxidative burst, cytokine production, chemotaxis, degranulation, phagocytosis, and RCD. While plasma zinc concentrations decline swiftly during both sepsis and COVID-19, this reduction is primarily attributed to a redistribution process associated with the inflammatory response. In this response, hepatic metallothionein production increases in reaction to cytokine release, which is linked to inflammation, and this protein effectively captures and stores zinc in the liver. Multiple regulatory mechanisms come into play, influencing the uptake of zinc, the binding of zinc to blood albumin and red blood cells, as well as the buffering and modulation of cytosolic zinc levels. Decreased zinc levels are associated with increasing severity of organ dysfunction, prolonged hospital stay and increased mortality in septic and COVID-19 patients. Results of recent studies focusing on these topics are summarized and discussed in this narrative review. Existing evidence currently does not support pharmacological zinc supplementation in patients with sepsis or COVID-19. Complementation and repletion should follow current guidelines for micronutrients in critically ill patients. Further research investigating the pharmacological mechanism of zinc in programmed cell death caused by invasive infections and its therapeutic potential in sepsis and COVID-19 could be worthwhile.

show abstract

Protective Effects of Micronutrient Supplements, Phytochemicals and Phytochemical-Rich Beverages and Foods Against DNA Damage in Humans: A Systematic Review of Randomized Controlled Trials and Prospective Studies

Cited by 17 publications

References 176 publications

Effect of maternal diet on the frequency of micronuclei in pregnant women and newborns: A protocol for systematic review and meta-analysis

Effect of maternal diet on the frequency of micronuclei in pregnant women and newborns: A protocol for systematic review and meta-analysis

Unlocking longevity: the role of telomeres and its targeting interventions

The Anti-Oxidative, Anti-Inflammatory, Anti-Apoptotic, and Anti-Necroptotic Role of Zinc in COVID-19 and Sepsis

Contact Info

Product

Resources

About