Protective effects of montelukast on ischemia-reperfusion injury in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation

Oral, Akgün; Odabaşoğlu, Fehmi; Halıcı, Zekai; Keleş, Osman Nuri; Ünal, Bünyami; Coşkun, Ali; Kılıç, Cenk; Surer, Ilhami; Salman, Ahmet Bedii

doi:10.1016/j.fertnstert.2010.08.017

Cited by 57 publications

(34 citation statements)

References 30 publications

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“…In the present study, a reduction in SOD and GSH levels and an increase in MDA levels occurred after a period of ischemia followed by reperfusion. The decreased SOD and GSH levels and the increased MDA levels after I/R were in agreement with previous studies [23,50,51]. The reduction in SOD and GSH levels and the increase in MDA levels during I/R were probably due to depletion of oxygen during oxidative stress.…”

Section: Discussionsupporting

confidence: 92%

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Nigella Sativa Reduces Tissue Damage in Rat Ovaries Subjected to Torsion and Detorsion: Oxidative Stress, Proinflammatory Response and Histopathological Evaluation

Bayır¹,

Karagöz

Karakuş³

et al. 2012

Gynecol Obstet Invest

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Background: To evaluate biochemically and histopathologically the effects of Nigella sativa (NS) in experimental ischemia and ischemia/reperfusion (I/R) injury in rat ovaries. Methods: Thirty-six female rats were divided into 6 groups: group I = sham operation; group II = 500 mg/kg NS + sham operation; group III = bilateral ovarian ischemia; group IV = 500 mg/kg NS + ischemia; group V = 3-hour period of ischemia + 3-hour reperfusion, and group VI: 3-hour period of ischemia + 500 mg/kg NS 2.5 h after the induction of ischemia + 3-hour reperfusion. At the end of ischemia, the bilateral vascular clips were removed, and 3-hour reperfusion was continued. IL-1β, IL-6, and TNF-α cytokine levels in serum, and superoxide dismutase (SOD), myeloperoxidase (MPO), glutathione (GSH), and malondialdehyde (MDA) levels were determined. Results: I/R increased the MDA level and MPO activity while significantly decreasing the SOD activity and GSH level when compared to the sham. The 500-mg/kg dose of NS before I/R reversed the trend in MDA levels, MPO activity, SOD activity, and GSH levels. Ischemia and I/R increased the serum levels of IL-1β, IL-6, and TNF-α, while the administration of NS decreased the serum levels of these cytokines. Conclusions: The administration of NS is effective in reversing tissue damage induced by ischemia and/or I/R in ovaries.

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Section: Discussionsupporting

confidence: 92%

“…Ovarian torsion represents biochemical and histopathological changes caused by I/R injury in the ovarian tissue as well as other I/R cases [4,23,50,51]. It is characterized by the production of ROS, depending on the decrease in blood flow to organs [52].…”

Section: Discussionmentioning

confidence: 99%

Nigella Sativa Reduces Tissue Damage in Rat Ovaries Subjected to Torsion and Detorsion: Oxidative Stress, Proinflammatory Response and Histopathological Evaluation

Bayır¹,

Karagöz

Karakuş³

et al. 2012

Gynecol Obstet Invest

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“…During reperfusion, depending on the supply of excess molecular oxygen to ischemic tissue, acute ischemic injury is worsened by the products of oxidative stress (free radicals and reactive oxygen species) [3,4]. Various markers have been used as antioxidant markers (such as superoxide dismutase, glutathione, and myeloperoxidase activity) and oxidative stress markers (such as malondialdehyde and nitric oxide) to evaluate I/R injury in rat ovarian tissues in previous studies [3,5,6].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Protective Effects of CoQ10 on Ovarian I/R Injury: An Experimental Study

Özler

Turgut

Görük

et al. 2013

Gynecol Obstet Invest

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Background: The aim of this study was to investigate the protective effects of coenzyme Q₁₀ (CoQ₁₀) on ovarian ischemia/reperfusion injury in an experimental rat adnexal torsion model. Methods: 48 female adult Wistar albino rats, weighing 220-250 g, were randomly equally divided into six groups (n = 8): sham, torsion, detorsion, sham+CoQ₁₀, torsion+CoQ₁₀, and detorsion+CoQ₁₀ groups. Bilateral adnexal torsion was performed for 3 h in all groups, except the sham and sham+CoQ₁₀ groups. Bilateral adnexal detorsion was performed on the detorsion and detorsion+CoQ₁₀ groups. CoQ₁₀ was injected intraperitoneally 30 min before the sham operation, torsion, and detorsion. Results: The torsion and detorsion groups had significantly higher histologic evaluation scores, as well as higher MDA levels, TOS values, and oxidative stress index values than the sham group. A strong correlation between total histologic evaluation scores for ischemia/reperfusion injury and the oxidative stress index was found. The mean oxidant marker levels and histopathologic scores for the ovarian tissue significantly decreased after using CoQ₁₀, which is a potent antioxidant. Conclusions: Conservative surgery (detorsion) was found to provide inadequate protection to ovarian tissue. The results of this study suggest that CoQ₁₀ could be useful for the protection of ovarian tissue before conservative surgery.

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“…Based on these studies, antiinflammatory-antioxidant agents may protect ovaries from I/R injury (Yigiter et al, 2011). Furthermore, a rat study by Oral et al (2011) showed that Montelukast's antiinflammatory and antioxidant effects decreased the incidence of I/R injury.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Allium sativum’s Protective Effect on Ovarian Reserve in an Experimental Ovarian Injury Model

et al. 2018

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SUMMARY:We aimed to evaluate the effects of detorsion and Allium sativum (garlic oil) treatment on the ovarian reserve in an ovarian torsion model. Ovarian torsion may lead to loss of ovarian tissue and infertility. It is an experimental rat study that was carried out on 16 sets of ovaries each, one for treatment group and a control group. In the control group, the procedure involved only the surgically opening and closing the abdomen. Bilateral adnexal torsion/detorsion was performed after a 3-hour ischemia period for the detorsion-only group. The detorsion + Allium sativum group received a 5 ml/kg dose of Allium sativum intraperitoneally, 2 hours before surgery. After the second surgery, removed ovarian samples were evaluated for follicle counts, damage scores and other parameters. Primordial, preantral, small antral and large antral follicle counts were significantly higher in the detorsion + Allium sativum group. Degeneration, congestion, hemorrhage ,inflammation and total damage scores were significantly elevated in the detorsion only group compared to those for the detorsion + Allium sativum group. Finally, there was a significant correlation between AMH alterations and postoperative, preantral follicle count (p<0.05). As a conclusion detorsion + Allium sativum treatment may be effective in protecting the ovarian reserve after torsion.

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Protective effects of montelukast on ischemia-reperfusion injury in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation

Cited by 57 publications

References 30 publications

<b><i>Nigella Sativa</i></b> Reduces Tissue Damage in Rat Ovaries Subjected to Torsion and Detorsion: Oxidative Stress, Proinflammatory Response and Histopathological Evaluation

<b><i>Nigella Sativa</i></b> Reduces Tissue Damage in Rat Ovaries Subjected to Torsion and Detorsion: Oxidative Stress, Proinflammatory Response and Histopathological Evaluation

Evaluation of the Protective Effects of CoQ<sub>10</sub> on Ovarian I/R Injury: An Experimental Study

Investigation of Allium sativum’s Protective Effect on Ovarian Reserve in an Experimental Ovarian Injury Model

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Protective effects of montelukast on ischemia-reperfusion injury in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation

Cited by 57 publications

References 30 publications

<b><i>Nigella Sativa</i></b> Reduces Tissue Damage in Rat Ovaries Subjected to Torsion and Detorsion: Oxidative Stress, Proinflammatory Response and Histopathological Evaluation

<b><i>Nigella Sativa</i></b> Reduces Tissue Damage in Rat Ovaries Subjected to Torsion and Detorsion: Oxidative Stress, Proinflammatory Response and Histopathological Evaluation

Evaluation of the Protective Effects of CoQ<sub>10</sub> on Ovarian I/R Injury: An Experimental Study

Investigation of Allium sativum&#8217;s Protective Effect on Ovarian Reserve in an Experimental Ovarian Injury Model

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Investigation of Allium sativum’s Protective Effect on Ovarian Reserve in an Experimental Ovarian Injury Model