2008
DOI: 10.1248/bpb.31.1422
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Protective Effects of Morroniside Isolated from Corni Fructus against Renal Damage in Streptozotocin-Induced Diabetic Rats

Abstract: Corni Fructus (Cornus officinalis SIEB. et ZUCC.), a traditional medicine, is considered one of the 25 plant-based drugs most frequently used in China, Japan, and Korea. Recent studies have reported that Corni Fructus has a plasma glucose-lowering action in normal rats, along with anti neoplastic and anti-microbial effects.1-3) Moreover, Vareed et al. 4) reported that Corni Fructus has been used for improving liver and kidney functions. The components are total iridoid glycosides such as morroniside and logani… Show more

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Cited by 77 publications
(44 citation statements)
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“…16,25) We reported the beneficial effect of morroniside on streptozotocin-induced type 1 diabetic renal damage in our previous study. 17) Morroniside was screened out in an on-going project to identify the main active compound of Corni Fructus, one of the eight component medicinal herbs contained in Hachimi-Jio-gan which have been used as traditional medicine for the treatment of diabetes. We have successively identified the main renoprotective active components of Corni Fructus through in vitro and in vivo studies.…”
Section: Discussionmentioning
confidence: 99%
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“…16,25) We reported the beneficial effect of morroniside on streptozotocin-induced type 1 diabetic renal damage in our previous study. 17) Morroniside was screened out in an on-going project to identify the main active compound of Corni Fructus, one of the eight component medicinal herbs contained in Hachimi-Jio-gan which have been used as traditional medicine for the treatment of diabetes. We have successively identified the main renoprotective active components of Corni Fructus through in vitro and in vivo studies.…”
Section: Discussionmentioning
confidence: 99%
“…1) was isolated from Corni Fructus as described previously. 17) Protease inhibitor mixture dimethyl sulfoxide (DMSO) solution, 4,6-dihydroxy-2-mercaptopyrimidine (2-thiobarbituric acid, TBA), oxalic acid, GSH, and GSSG were purchased from Wako Pure Chemical Industries, Ltd. (Osaka, Japan Experimental Protocol All experiments were performed according to the animal care guidelines of the University of Toyama. Five-week-old male C57BLKS/J db/db and m/m mice were purchased from Japan SLC Inc. (Hamamatsu, Japan).…”
Section: Methodsmentioning
confidence: 99%
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