2018
DOI: 10.21315/mjms2018.25.5.5
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Protective Effects of N-Acetyl-L-Cysteine on the Density of Spiral Ganglion Cells and Histological Changes Induced by Continuous Noise Exposure in Rats

Abstract: BackgroundNoise exposure causes loss of cochlea hair cells, leading to permanent sensorineural hearing loss, and initiates pathological changes to the bipolar primary auditory neurons (ANs). This study focuses on the effects of N-acetyl-l-cysteine (NAC) in protecting the density of spiral ganglion cells and in histological changes induced by continuous noise exposure in rats.MethodsTwenty-four male Wistar rats were randomly allocated into four experimental groups to receive NAC, saline, noise, or both noise an… Show more

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Cited by 6 publications
(2 citation statements)
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“…Finally, L-NAC's antioxidant effects protect against damage to vascular endothelial cells by the same mechanisms, especially by mediating NO and RNS, further limiting the influx of inflammatory mediators [30]. Our findings are in agreement with these studies demonstrating ability of L-NAC to attenuate the generation of NO and ROS that prevent damage to sensory cells [9,31].…”
Section: Discussionsupporting
confidence: 90%
“…Finally, L-NAC's antioxidant effects protect against damage to vascular endothelial cells by the same mechanisms, especially by mediating NO and RNS, further limiting the influx of inflammatory mediators [30]. Our findings are in agreement with these studies demonstrating ability of L-NAC to attenuate the generation of NO and ROS that prevent damage to sensory cells [9,31].…”
Section: Discussionsupporting
confidence: 90%
“…The samples were cut on the perimodiolar plane (At a thickness of 5 μm) using a rotary microtome. Every third section was mounted on a glass slide and stained with haematoxylin and eosin and examined under light microscope (Habybabady et al, 2018). Image analysis was performed by image analysis software program (Image J. version 1.39 p, Java 1.6) which was used to measure the mean count of spiral ganglia in all groups.…”
Section: Histopathological Examination Of the Cochlear Tissuesmentioning
confidence: 99%