Protective Effects of N-acetylcysteine and a Prostaglandin E1 Analog, Alprostadil, Against Hepatic Ischemia: Reperfusion Injury in Rats

Hsieh, Cheng-Chu; Hsieh, Shu-Chen; Chiu, Jen‐Hwey; Wu, Ying-Ling

doi:10.4103/2225-4110.124351

Cited by 24 publications

(23 citation statements)

References 50 publications

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“…More recent studies on animal small intestine and liver tissues have suggested a beneficial effect of PGE1 on ischemia/reperfusion injury …”

mentioning

confidence: 99%

“…The hepatoprotective effects of prostaglandins were initially demonstrated in animal models, including dimethylnitrosamineinduced liver injury, (2) carbon tetrachloride-induced liver injury, (3) and ischemia/reperfusion injury. (4) An immunomodulatory effect has also been proposed for exogenous prostaglandins, based on animal models of polyarthritis in rats and systemic lupus erythematosus in mice. (5,6) A number of mechanisms have been proposed to explain the hepatoprotective effects of prostaglandins, (7)(8)(9)(10)(11)(12) which include the following:…”

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confidence: 99%

“…Stabilizing the membrane microviscosity. 4. Decreasing the cell-mediated cytotoxicity against hepatocytes.…”

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confidence: 99%

“…(13) More recent studies on animal small intestine and liver tissues have suggested a beneficial effect of PGE1 on ischemia/reperfusion injury. (14)(15)(16) The use of PGE1 in the treatment of established PNF was first reported by Greig et al in 1989. (17) Two randomized trials studied the role of perioperative PGE1 infusion in DDLT recipients.…”

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confidence: 99%

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Perioperative prostaglandin e1 infusion in living donor liver transplantation: A double‐blind, placebo‐controlled randomized trial

Bharathan¹,

Chandran²,

Gopalakrishnan³

et al. 2016

Liver Transpl

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The role of prostaglandin E1 (PGE1) infusion in improving early graft function has not been well defined, especially in the scenario of living donor liver transplantation (LDLT). We designed a randomized, double-blind, placebo-controlled trial to evaluate the role of perioperative PGE1 infusion in LDLT. Patients in the study arm received PGE1 (alprostadil) at the rate of 0.25 μg/kg/hour, starting at 1 hour after portal venous reperfusion, and continued for 96 hours. The primary endpoint was early allograft dysfunction (EAD). We analyzed multiple secondary endpoints including postoperative liver function and renal function parameters, acute kidney injury (AKI), hepatic artery thrombosis (HAT), postoperative bleeding, overall mortality, and posttransplant hospital stay. The incidence of EAD was lower in the PGE1 arm, although the difference did not reach statistical significance (22.4% versus 36%; P = 0.21). Among the secondary endpoints, the incidence of AKI was significantly lower in the PGE1 arm (8.2% versus 28%; P = 0.02), as were the peak and mean postoperative creatinine levels. The need for renal replacement therapy was similar between the 2 groups. Among the postoperative graft function parameters, postoperative alanine aminotransferase level was significantly lower in the PGE1 arm (P = 0.04), whereas the remaining parameters including serum bilirubin, aspartate aminotransferase, and international normalized ratio were similar between the 2 arms. There was no difference in the incidence of HAT and postoperative bleeding, in-hospital mortality, and posttransplant hospital stay between the 2 arms. Perioperative PGE1 infusion reduces the incidence of posttransplant renal dysfunction in patients undergoing LDLT. Liver Transplantation 22 1067-1074 2016 AASLD.

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“…More recent studies on animal small intestine and liver tissues have suggested a beneficial effect of PGE1 on ischemia/reperfusion injury …”

mentioning

confidence: 99%

mentioning

confidence: 99%

“…Stabilizing the membrane microviscosity. 4. Decreasing the cell-mediated cytotoxicity against hepatocytes.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

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Perioperative prostaglandin e1 infusion in living donor liver transplantation: A double‐blind, placebo‐controlled randomized trial

Bharathan¹,

Chandran²,

Gopalakrishnan³

et al. 2016

Liver Transpl

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“…Previous studies have shown that N-acetylcysteine attenuated I/R injury on liver and intestine in normothermic conditions 7,9,10 . In experimental hepatic ischemic injury, the treatment with the N-acetylcysteine, immediately before ischemia, preserved morphological architecture and tissue functionality during ischemia [8][9][10] .…”

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confidence: 92%

The effect of n-acetylcysteine on hepatic histomorphology during hypothermic preservation

et al. 2014

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. Tutor. Responsible for conception, design, intellectual and scientific content of the study. Final approval of the version to be published. ABSTRACT PURPOSE:To evaluate the NAC effects on liver hypothermic preservation at different time intervals. METHODS:For this, we used livers of male Wistar rats weighing between 250 and 300g, undergoing preservation in Ringer solution at 4°C for up to 24 hours. Tissue samples were obtained at four moments of preservation for histological examination by hematoxylin and eosin staining: T0 = beginning of preservation, T12 = 12 hours, T18 = 18 hours and T24 = 24 hours. Will be analyzed vacuolation, hepatic apoptosis by optical microscopy and parenchymal. RESULTS:The results showed a progressive increase in hepatic injury in both groups and showed that NAC was effective at T0. The parenchyma preservation was better in the NAC group and no difference when vacuolization of the cells. CONCLUSION:Hypothermic preservation, over time, causes changes in the hepatic parenchyma with increased apoptosis, loss of architecture, vacuolization, culminating in severe injury. The administration of N-acetylcysteine protects against preservation liver injury.

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Prostaglandins for adult liver transplanted recipients

Mohamed,

Varghese,

Sudhakar

et al. 2023

Cochrane Database of Systematic Reviews

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Protective Effects of N-acetylcysteine and a Prostaglandin E1 Analog, Alprostadil, Against Hepatic Ischemia: Reperfusion Injury in Rats

Cited by 24 publications

References 50 publications

Perioperative prostaglandin e1 infusion in living donor liver transplantation: A double‐blind, placebo‐controlled randomized trial

Perioperative prostaglandin e1 infusion in living donor liver transplantation: A double‐blind, placebo‐controlled randomized trial

The effect of n-acetylcysteine on hepatic histomorphology during hypothermic preservation

Prostaglandins for adult liver transplanted recipients

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