Protective effects of natural compounds against paraquat-induced pulmonary toxicity: the role of the Nrf2/ARE signaling pathway

Badibostan, Hasan; Eizadi-Mood, Nastaran; Hayes, A. Wallace; Karimi, Gholamreza

doi:10.1080/09603123.2022.2163985

Cited by 7 publications

(1 citation statement)

References 86 publications

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“…The results exposed here follow our data previously obtained. In fact, fibroblasts exposed to UVA rays, especially after two hours, show an increase of intracellular ROS levels and of the associated apoptotic molecular events (increase in the Bcl2/Bax ratio), involving the Nrf2 signal transduction pathways [ 36 , 37 , 38 , 39 , 40 , 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

Rutin Protects Fibroblasts from UVA Radiation through Stimulation of Nrf2 Pathway

et al. 2023

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This study explores the photoprotective effects of rutin, a bioflavonoid found in some vegetables and fruits, against UVA-induced damage in human skin fibroblasts. Our results show that rutin increases cell viability and reduces the high levels of ROS generated by photo-oxidative stress (1 and 2 h of UVA exposure). These effects are related to rutin’s ability to modulate the Nrf2 transcriptional pathway. Interestingly, activation of the Nrf2 signaling pathway results in an increase in reduced glutathione and Bcl2/Bax ratio, and the subsequent protection of mitochondrial respiratory capacity. These results demonstrate how rutin may play a potentially cytoprotective role against UVA-induced skin damage through a purely antiapoptotic mechanism.

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