Protective Effects of Nephelium lappaceum Rind Extract against Collagen-induced Arthritis in Dark Agouti Rats

Kumar, Shashi; Chakravarthi, Srikumar; Seng, Chiew Gan; Subramaniam, Thavamanithevi; Palanisamy, Umadevi; Radhakrishnan, Ammu Kutty; Haleagrahara, Nagaraja

doi:10.3923/jbs.2012.385.392

Cited by 14 publications

(8 citation statements)

References 15 publications

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“…(2020) Retinoic Acid-Induced Osteoporosis in Rats Calcium, phosphorus ALP, OCN in serum Organ coefficients of femur, tibia, and liver Femoral and tibial length, BMD, bone calcium content in bone Histopathology of bone Anti-inflammatory activities LPS-induced RAW 264.7 cell model NO overproduct Increased iNOS level Li et al. (2018) Collagen-induced arthristis in Dark Agouti rats Plasma C-Reactive protein Joint morphology Immunohistochemistry of MMP-13 and TIMP-1 Kumar et al. (2012) Antiproliferative activities the human cell lines KB and Caco-2 cells Inhibited the growth of KB cervical adenocarcinoma Inhibited the growth of Caco-2 colorectal adenocarcinoma cells Khonkarn et al.…”

Section: Biological Activitymentioning

confidence: 99%

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A review: extraction, phytochemicals, and biological activities of rambutan (Nephelium lappaceum L) peel extract

Zhang

Zhou

Wang

et al. 2022

Heliyon

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Section: Biological Activitymentioning

confidence: 99%

“…Rambutan peel extract also showed positive influence on rheumatoid arthritis, a chronic inflammatory disease that mainly targets the synovial tissue, cartilage, and subchondral bone. The effect of rambutan peel extract on collagen-induced arthritis (CIA) in dark agouti rats was studied by Kumar et al. (2012) .…”

Section: Biological Activitymentioning

confidence: 99%

A review: extraction, phytochemicals, and biological activities of rambutan (Nephelium lappaceum L) peel extract

Zhang

Zhou

Wang

et al. 2022

Heliyon

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“…o.) of animal [12]. The solutions were freshly prepared on the day of an experiment by dissolving in distilled water and administered orally.…”

Section: Dose Selectionmentioning

confidence: 99%

“…Also it showed to contain substances exhibiting antioxidant activity such as ascorbic acid and phenolic compounds (anthocyanins, flavonoids, tannins, ellagic acid, corilagin, and geraniin) [8]. Rambutan rind has many uses such as Anti-viral/Anti-Herpes [9], Anti-oxidant [10], Anti-bacterial [10], Anti-Hyperglycaemic [11], Anti-Inflammatory [11], and Anti-proliferative [12].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Immunomodulatory Activity of Extract From Rind of Nephelium Lappaceum Fruit

Shrestha

Handral

2016

Int J Pharm Pharm Sci

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Objective: Nephelium lappaceum Linn (Sapindaceae), also known as Rambutan is a tropical fruit native to Malaysia. The rind of Rambutan, which is normally discarded, has been used in the present research work to explore the immunomodulatory activity of ethanolic extract and also its protective effect against cyclophosphamide (CP) induced immunosuppression.Methods: The assessment of immunomodulatory activity was carried by testing the humoral (Haemagglutination antibody titre (HA) model), cell-mediated immunity (delayed type hypersensitivity reaction model), haematological parameters, carbon clearance assay (phagocytic index), organ index (spleen and thymus) and histopathological study of mice thymus.Results: Administration of the ethanolic extract significantly increased the antibody titre and DTH response in response to sheep red blood cells when compared to normal control and CP control group. There was a prominent increase in the WBC count, spleen index, thymus index and the phagocytic index in immune suppressed group treated with ethanolic extract of Nephelium lappaceum rind compared to the immune suppressed control group.Conclusion: The result suggests that the ethanolic extract has the potential to modulate the immune system as well has a protective effect against CP-induced immune suppression.

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“…In some fruits, the peel has higher bioactivity than the edible portion of the fruit, and rambutan’s peel is not an exception. Studies conducted from biological assays have proved the great potential of this agricultural waste as an antioxidant, antimicrobial, antiviral, anticancer, anti-allergic, anti-obesity, antidiabetic, anti-arthritic, as well as a promoter of cardiovascular health [ 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. Despite the proven properties of rambutan, its waste has been little exploited.…”

Section: Introductionmentioning

confidence: 99%

Recovery of Bioactive Ellagitannins by Ultrasound/Microwave-Assisted Extraction from Mexican Rambutan Peel (Nephelium lappaceum L.)

et al. 2022

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Rambutan (Nephelium lappaceum L.) is a tropical fruit from Asia which has become the main target of many studies involving polyphenolic analysis. Mexico produces over 8 million tons per year of rambutan, generating a huge amount of agro-industrial waste since only the pulp is used and the peel, which comprises around 45% of the fruit’s weight, is left behind. This waste can later be used in the recovery of polyphenolic fractions. In this work, emerging technologies such as microwave, ultrasound, and the hybridization of both were tested in the extraction of phenolic compounds from Mexican rambutan peel. The results show that the hybrid technology extraction yielded the highest polyphenolic content (176.38 mg GAE/g of dry rambutan peel). The HPLC/MS/ESI analysis revealed three majoritarian compounds: geraniin, corilagin, and ellagic acid. These compounds explain the excellent results for the biological assays, namely antioxidant activity evaluated by the DPPH, ABTS, and LOI (Lipid oxidation inhibition) assays that exhibited great antioxidant capacity with IC50 values of 0.098, 0.335, and 0.034 mg/mL respectively, as well as prebiotic activity demonstrated by a µMax (maximum growth) of 0.203 for Lactobacillus paracasei. Lastly, these compounds have shown no hemolytic activity, opening the door for the elaboration of different products in the food, cosmetic, and pharmaceutical industries.

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Protective Effects of Nephelium lappaceum Rind Extract against Collagen-induced Arthritis in Dark Agouti Rats

Cited by 14 publications

References 15 publications

A review: extraction, phytochemicals, and biological activities of rambutan (Nephelium lappaceum L) peel extract

A review: extraction, phytochemicals, and biological activities of rambutan (Nephelium lappaceum L) peel extract

Evaluation of Immunomodulatory Activity of Extract From Rind of Nephelium Lappaceum Fruit

Recovery of Bioactive Ellagitannins by Ultrasound/Microwave-Assisted Extraction from Mexican Rambutan Peel (Nephelium lappaceum L.)

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