Protective Effects of New Herbal Composition (MH-30) against Radiation Injuries in Hematopoietic and Self-Renewal Tissues

정우희,; 박혜란,; 이호용,; 백가영,; 조성기,

doi:10.3746/jkfn.2016.45.7.948

Cited by 3 publications

(6 citation statements)

References 35 publications

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“…HemoHIM has low levels of fatsoluble polyphenols because it is decocted with boiling water in a traditional way. We recently developed MH-30 from the same herbs was HemoHIM by decocting with 30% ethanol and hot water to enhance the fat-soluble polyphenol contents and confirmed that various fat-soluble polyphenol compounds in MH-30 were at higher levels compared to HemoHIM (49). Decursin contents in MH-30 were 8.7-fold higher than HemoHIM.…”

Section: Discussionmentioning

confidence: 77%

“…Whereas there are reports that agents causing oxidative stress such as allopurinol or augmenting lipid peroxidation such as gemcitabine enhance the nephrotoxicity of cisplatin (67,68). In a previous study, MH-30 showed high superoxide and hydroxyl radical scavenging activity (49). Interestingly, antioxidants and scavengers of superoxide anion or hydrogen peroxide prevented necrosis induced by cisplatin in vitro, whereas hydroxyl radical scavengers partially blocked apoptosis caused by lower doses of cisplatin (69).…”

Section: Discussionmentioning

confidence: 83%

“…Accordingly, we decocted the above three herbs by 30% ethanol and hot water to improve the antioxidant efficacy by increasing the levels of fat-soluble polyphenols and designated the product MH-30. Recently, we showed through HPLC analysis that MH-30 has a higher content of fat-soluble polyphenol compounds than HemoHIM (8.7 times higher for decursin), suggesting that MH-30 has significantly increased protective efficacy against ionizing radiation compared with HemoHIM (49).…”

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confidence: 99%

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Synergistic Anti-cancer Activity of MH-30 in a Murine Melanoma Model Treated With Cisplatin and its Alleviated Effects Against Cisplatin-induced Toxicity in Mice

Park

Cho

et al. 2020

In Vivo

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Background/Aim: Although cisplatin is an effective anticancer drug, its toxic effects on normal tissues limit its use. We developed a herbal formula, MH-30, with increased fat-soluble polyphenols by improving the manufacturing method of HemoHIM. In this study, we examined whether the combination of MH-30 with cisplatin exerts synergistic antitumor effect while it reduces cisplatininduced toxicities. Materials and Methods: MH-30 was produced by adding the ethanol-insoluble fraction to its extract after decocting herbs in 30% ethanol and water. We used a melanoma-bearing mice model to investigate synergistic anticancer effects. The NK cell activity and cytokine levels were measured by Cr 51-release assay and ELISA. The AST, ALT, BUN, and creatinine levels were estimated in the serum. Results: MH-30 effectively inhibited melanoma growth in vitro. Furthermore, MH-30 had a synergistic effect in combination with cisplatin on melanoma growth inhibition in vitro and in vivo. In melanoma-bearing mice, cisplatin alone decreased the activity of NK cells and the levels of IL-2 and IFN-γ, which were effectively restored by the combination of MH-30 with cisplatin. Combined treatment with MH-30 and cisplatin significantly inhibited the cisplatin-induced increase in the levels of AST, ALT, BUN, and creatinine. Conclusion: Combination of MH-30 with cisplatin may be a beneficial anticancer treatment with reduced adverse effects.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 83%

mentioning

confidence: 99%

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Synergistic Anti-cancer Activity of MH-30 in a Murine Melanoma Model Treated With Cisplatin and its Alleviated Effects Against Cisplatin-induced Toxicity in Mice

Park

Cho

et al. 2020

In Vivo

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“… 2009 ; Jung et al. 2016 ). These findings indicate that HemoHIM should be effective at improving fatigue caused by oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and antifatigue effect of a standardized fraction (HemoHIM) from Angelica gigas , Cnidium officinale , and Paeonia lactiflora

Kwon

Kim

et al. 2021

Pharmaceutical Biology

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Context HemoHIM is an herbal preparation containing Angelica gigas Nakai (Apiaceae), Cnidium officinale Makino (Umbelliferae), and Paeonia lactiflora Pallas (Paeoniaceae) developed for immune regulation. To date, studies on the antifatigue effects of HemoHIM have not been conducted. Objective The antifatigue effects of HemoHIM using models of citrinin and exercise-induced chronic fatigue syndrome were investigated. Materials and methods Citrinin-induced L6 skeletal muscle cells were treated with HemoHIM (125, 250, and 500 μg/mL). The antioxidant factors were analysed. ICR mice were divided into four groups (n = 10): control, HemoHIM 250, 500 mg/kg, and creatine 300 mg/kg, respectively. Mice were orally administered HemoHIM or creatine for three weeks; during this time, both rotarod test and forced swimming test (FST) were conducted. The latency time was investigated and antioxidant, antifatigue factors were analysed. Results HemoHIM significantly restored reduced antioxidant enzymes (SOD, CAT, Txn, GPx, GSr, and GCLC in HemoHIM 500 μg/mL) compared to the citrinin group in L6 cells. In vivo , HemoHIM significantly improved the latency time (FST; 279.88 ± 50.32 sec, rotarod test; 552.35 ± 23.50 sec in HemoHIM 500 mg/kg). Moreover, the FST-induced reduction in glucose and glutathione significantly increased by 3-fold (HemoHIM 500 mg/kg) and increase in LDH and MDA were significantly inhibited by 1.6, 2.1-fold in the HemoHIM 500 mg/kg compared to the control group.

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“…HemoHIM is a herbal medicine composed of hot water extracts of Angelica gigas Nakai, Cnidium officinale Makino, and Paeonia japonica Miyabe with enhanced crude polysaccharide content, which are active ingredients that enhance immunity and hematopoiesis. HemoHIM has anticancer effect while reducing chemotherapy side effect [30], aids the recovery from immune imbalance [20], and shows anti-inflammatory effects in respiratory inflammation [31]. Although there have been studies that investigated the effects of HemoHIM in inflammatory diseases and immunity, there have been no studies in the context of immunosuppression by cisplatin, which is used as an immunosuppressive agent and an anticancer agent.…”

Section: Discussionmentioning

confidence: 99%

Preventive Effect of the Herbal Preparation, HemoHIM, on Cisplatin-Induced Immune Suppression

Kim

Kwon

Lee

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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We determined the functional effect of the herbal preparation, HemoHIM, on the immune system, by examining the immunomodulatory activities of HemoHIM using immunocompromised mice. In this study, to examine the effect on the restoration of immune cells and balance in the immune system, we utilized a cisplatin-induced immunosuppression mouse model. Mice were injected intraperitoneally with cisplatin, an immunosuppressive anticancer, and then received oral doses of 100, 250, and 500 mg/kg of HemoHIM for 14 days. The HemoHIM prevented the cisplatin-induced loss of body and organ weight. In terms of innate immunity, natural killer (NK) cell activity and phagocytosis increased in the HemoHIM group compared to the cisplatin control group. The HemoHIM group also showed a significantly higher expression of Th1-mediated cytokines (interferon gamma (IFN-γ), interleukin-2 (IL-2), and tumor necrosis factor alpha (TNF-α)) and inhibited the production of Th2-mediated cytokine interleukin-4 (IL-4) compared to cisplatin control group. These findings indicate that HemoHIM enhances immune activity by modulating immune cell activity and cytokine secretion in immune-suppressed mice.

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Protective Effects of New Herbal Composition (MH-30) against Radiation Injuries in Hematopoietic and Self-Renewal Tissues

Cited by 3 publications

References 35 publications

Synergistic Anti-cancer Activity of MH-30 in a Murine Melanoma Model Treated With Cisplatin and its Alleviated Effects Against Cisplatin-induced Toxicity in Mice

Synergistic Anti-cancer Activity of MH-30 in a Murine Melanoma Model Treated With Cisplatin and its Alleviated Effects Against Cisplatin-induced Toxicity in Mice

Antioxidant and antifatigue effect of a standardized fraction (HemoHIM) from Angelica gigas , Cnidium officinale , and Paeonia lactiflora

Preventive Effect of the Herbal Preparation, HemoHIM, on Cisplatin-Induced Immune Suppression

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