2018
DOI: 10.1016/j.arcmed.2018.12.006
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Protective Effects of Nicorandil on Cardiac Function and Left Ventricular Remodeling in a Rat Model of Ischemic Heart Failure

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Cited by 9 publications
(8 citation statements)
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“…Then, the influx of calcium is reduced, leading to the relaxation of vascular smooth muscle and vasodilation. 16,23…”
Section: Discussionmentioning
confidence: 99%
“…Then, the influx of calcium is reduced, leading to the relaxation of vascular smooth muscle and vasodilation. 16,23…”
Section: Discussionmentioning
confidence: 99%
“…In chronic CHF, animal studies have suggested a favorable impact of NCO on myocardial remodeling and fibrosis in ischemic and hypertensive heart failure, 154,155 inhibition of mitochondrial oxidative stress and apoptosis in drug-induced and hypoxic myocardial injury, [156][157][158] and increased myocardial capillary and arteriolar densities by modulation of tissue growth factor gene expression. 159,160 Evidence for clinical use in humans with chronic CHF has only recently begun to emerge and seems encouraging in terms of hard outcome reduction (Table 3).…”
Section: Nco In Congestive Heart Failurementioning
confidence: 99%
“…A suture was placed 1-1.5 mm from the left anterior descending branch (LAD), and the ends were tied loosely in the SO group and firmly in the HF group (25). After 4 weeks, HF followed by myocardial infarction was confirmed by multiple morphological and hemodynamic parameters (mainly due to LVEF lower than 50%) and myocardial tissues were collected from the infarcted edge area of all eligible rats (26,27).…”
Section: Validation Of Programmed Cell Death Related Genes In Cerna Network In Hf Animal Modelmentioning
confidence: 99%