Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model

Chen, Chang-Mu; Lin, Chia-Chen; Chung, Yao-Pang; Liu, Chia-Hung; Huang, Kuo-Tong; Guan, Siao-Syun; Wu, Cheng-Tien; Liu, Shing‐Hwa

doi:10.3390/nu13113921

Cited by 19 publications

(14 citation statements)

References 55 publications

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“…NK is also isolated from grapefruit and pummel [13]. It has been reported that NK has several pharmacological properties such as antimicrobial, antioxidant, antifibrotic and anti-allergic activities [14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

“…Since cardiac toxicity related to DOXO involves oxidative stress and apoptosis at early events and fibrosis and cardiac dysfunction as late events and NK has potential anti-oxidant activities at early events as well as has palliative effects against some experimental diseases involving inflammation and oxidative stress [6,10,[14][15][16][17][18][19][20], we considered that it was relevant to assess the possible protective effects of NK on early DOXO-induced cardiac toxicity and the mechanisms underlying these effects in mice.…”

Section: Introductionmentioning

confidence: 99%

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Nootkatone Ameliorates Doxorubicin Induced Myocardial Injury through Modulation of NF-κB Signals and Oxidative Stress

Al‐Salam

Karthishwaran

Sudhadevi

et al. 2022

Cell Physiol Biochem

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BACKGROUND/AIMS: Doxorubicin (DOXO) is a potent chemotherapeutic drug that is used in the treatment of a large number of cancers. Despite its important chemotherapeutic characteristics, its usage is limited because of the serious side effects; the most noticeable is cardiotoxicity which can manifest acutely or years after completion of treatment leading to left ventricular dysfunction, dilated cardiomyopathy and heart failure. Nootkatone (NK) is a recognized bioactive compound isolated from the heartwood of Cupressus nootkatensis and has been reported to have antiseptic, antioxidant, and anti-allergic activities. METHODS: Male C57B6/J mice were used for mice model of DOXO-cardiac toxicity. Mice were given either DOXO or NK or DOXO+NK or vehicle (normal saline) after which the mice again had free access to food and water. Heart and plasma samples were collected 5 days after DOXO administration and were used for immunohistochemistry, electron microscopy and enzyme linked immunosorbent assay (ELISA). RESULTS: There were significant reduction in inflammatory markers in hearts of DOXO-NK- treated mice when compared with DOXO-treated mice. Moreover, there were significant increase in antioxidant proteins and reduction of oxidative stress in hearts of DOXO-NK-treated mice when compared with DOXO-treated mice. There was a significant reduction in myocardial damage as shown by significant reduction of troponin I in DOXO-NK- treated mice when compared with DOXO-treated mice. CONCLUSION: Nootkatone improves DOXO-induced myocardial injury through modulation of NF-κB signals and reduction of oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nootkatone Ameliorates Doxorubicin Induced Myocardial Injury through Modulation of NF-κB Signals and Oxidative Stress

Al‐Salam

Karthishwaran

Sudhadevi

et al. 2022

Cell Physiol Biochem

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“…Nahuoic acid A (29), oleamide (37), erucamide (52), oligomycin C (78), and plakevulin A (101) are known as inhibitors of different enzymes [52][53][54][55]. Some of identified compounds (17,18,34,37,41,59, and 111) are characterized by anti-inflammatory or antimalarial properties [42,43,49,[56][57][58].…”

Section: Discussionmentioning

confidence: 99%

A Novel Approach for Fast Screening of a Complex Cyanobacterial Extract for Immunomodulatory Properties and Antibacterial Activity

Teneva

Batsalova

Bardarov³

et al. 2022

Applied Sciences

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The filamentous cyanobacteria from genus Phormidium are rich natural sources of bioactive compounds that could be exploited as pharmaceuticals or nutraceuticals. In this study, we suggest a novel approach for assessing the immunomodulatory properties of the products derived from cyanobacteria. The influence of Phormidium papyraceum extract on the human leukocyte immunophenotype was evaluated by attempting to link this activity to certain putative compounds identified in the extract. By using three staining panels and flow cytometry, we found that the cyanobacterial extract affected mainly CD4+ T cells upregulating activated CD4+CD152+ T cells (15.75 ± 1.93% treated vs. 4.65 ± 1.41% control) and regulatory CD4+CD25+ T cells (5.36 ± 0.64% treated vs. 1.03 ± 0.08% control). Furthermore, P. papyraceum extract can modulate T cell subpopulations with a CD4+ effector/memory phenotype. Extract-treated cells showed increased production of IL-2 (55 ± 12 pg/mL) and IL-6 (493 ± 64 pg/mL) compared to the untreated, 21 ± 7 pg/mL and 250 ± 39 pg/mL, respectively. No significant changes were observed in the secretion of TNF-α. In addition, P. papyraceum extract displayed antibacterial activity against both Gram-negative (inhibition zone from 18.25 ± 0.50 mm to 20.28 ± 1.50 mm) and Gram-positive (inhibition zone from 10.86 ± 0.85 mm to 17.00 ± 0.82 mm) bacteria. The chemical profile of the cyanobacterial extract was determined using LC–ESI–MS/MS analysis, where at least 112 putative compounds were detected. Many of these compounds have proven different biological activities. We speculated that compounds such as betulin and the macrolide azithromycin (or their analogues) could be responsible for the immunomodulatory potential of the investigated extract. More studies are needed to determine and validate the biological activities of the determined putative compounds.

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“…Apoptosis (a programmed cell death) of glomerular ECs, podocytes, and TECs is closely associated with RF (Thomas et al, 1998;Docherty et al, 2006). Inhibition of apoptosis as a therapeutic target can alleviate fibrosis (Chen et al, 2021;Xia et al, 2021;Park et al, 2022). Cordyceps downregulates apoptosis in ischemia/reperfusion injury and Cyclosporine A-induced renal tubular dysfunction (Shahed et al, 2001;Chyau et al, 2014).…”

Section: Cordyceps Inhibits Apoptosismentioning

confidence: 99%

Potential Therapeutic Strategies for Renal Fibrosis: Cordyceps and Related Products

Wang

Dai³

et al. 2022

Front. Pharmacol.

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At present, there is no effective drug for the treatment of renal fibrosis; in particular, a safe and effective treatment for renal fibrosis should be established. Cordyceps has several medical effects, including immunoregulatory, antitumor, anti-inflammatory, and antioxidant effects, and may prevent kidney, liver, and heart diseases. Cordyceps has also been reported to be effective in the treatment of renal fibrosis. In this paper, we review the potential mechanisms of Cordyceps against renal fibrosis, focusing on the effects of Cordyceps on inflammation, oxidative stress, apoptosis, regulation of autophagy, reduction of extracellular matrix deposition, and fibroblast activation. We also discuss relevant published clinical trials and meta-analyses. Available clinical studies support the possibility that Cordyceps and related products provide benefits to patients with chronic kidney diseases as adjuvants to conventional drugs. However, the existing clinical studies are limited by low quality and significant heterogeneity. The use of Cordyceps and related products may be a potential strategy for the treatment of renal fibrosis. Randomized controlled trial studies with good methodological quality, favorable experimental design, and large sample size are needed to evaluate the efficacy and safety of Cordyceps.

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Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model

Cited by 19 publications

References 55 publications

Nootkatone Ameliorates Doxorubicin Induced Myocardial Injury through Modulation of NF-κB Signals and Oxidative Stress

Nootkatone Ameliorates Doxorubicin Induced Myocardial Injury through Modulation of NF-κB Signals and Oxidative Stress

A Novel Approach for Fast Screening of a Complex Cyanobacterial Extract for Immunomodulatory Properties and Antibacterial Activity

Potential Therapeutic Strategies for Renal Fibrosis: Cordyceps and Related Products

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