Protective Effects of Oleuropein Against Cerebral Ischemia/Reperfusion by Inhibiting Neuronal Apoptosis

Zhang, Weijing; Liu, Xiaogang; Li, Qiuyue

doi:10.12659/msm.912336

Cited by 21 publications

(15 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to anti‐inflammatory and bone‐protective effects, oleuropein also has potent anti‐apoptotic effects reported through decreased bax and caspase‐3 levels and increased bcl‐2 levels by Zhang et al . Supporting the anti‐apoptotic effect of oleuropein, Potocnjak et al also reported reduced dose‐dependent caspase‐3 and bax expressions with 5, 10, and 20 mg/kg administration of oleuropein ,.…”

Section: Discussionmentioning

confidence: 90%

“…37 In contrast, the results of the present study showed that oleu- CD68 can be considered as an indicator of accumulated macrophage and monocyte lineage cells, and increased levels in the periodontitis indicate increased inflammation. 45,46 In addition to anti-inflammatory and bone-protective effects, oleuropein also has potent anti-apoptotic effects reported through decreased bax and caspase-3 levels and increased bcl-2 levels by Zhang et al 47 Supporting the anti-apoptotic effect of oleuropein, Potocnjak et al also reported reduced dose-dependent caspase-3 and bax expressions with 5, 10, and 20 mg/kg administration of oleuropein. 48 , 100, and 300 mg/kg doses of oleuropein also exhibited an anti-apoptotic effect in indomethacin-induced toxicity in rats.…”

Section: Inos Bmp-4 Cd68 Caspase-3 and Bcl-2 Immunostaining Resmentioning

confidence: 96%

See 1 more Smart Citation

Evaluation of the effect of oleuropein on alveolar bone loss, inflammation, and apoptosis in experimental periodontitis

Taşkan

Yüce

Karataş

et al. 2019

J of Periodontal Research

View full text Add to dashboard Cite

The Objective The present study aimed to evaluate the effects of oleuropein on ligature‐induced alveolar bone loss. In this respect, osteoblastic activity, osteoclastic activity, inflammatory markers, and apoptosis were evaluated. Background Oleuropein is a flavonoid, which has potent anti‐inflammatory and bone‐protective effects. Methods Thirty‐two Wistar rats were divided into four experimental groups as following: control (C, n = 8) group; periodontitis (P, n = 8) group; periodontitis and low‐dose oleuropein group (12 mg/kg/day oleuropein, LDO group, n = 8); and periodontitis and high‐dose oleuropein group (24 mg/kg/day oleuropein, HDO group, n = 8). Periodontitis was induced via ligatures. Study period was 14 days, and animals were sacrificed at end of this period. Mandibles were examined via a stereomicroscope and underwent histological procedures. Osteoblast, tartrate‐resistant acid phosphatase (TRAP)‐positive osteoclast, and inflammatory cell counts were determined in hematoxylin‐eosin stained sections. Inducible nitric oxide synthase (iNOS), bone morphogenetic protein‐4, the cluster of differentiation (CD)‐68, cysteine‐aspartic proteases‐3 (Caspase 3), and B‐cell lymphoma‐2 (Bcl‐2) expressions were evaluated via immunohistochemistry. Results Periodontitis group had highest alveolar bone loss, and these levels significantly decreased in LDO and HDO groups. Both 12 and 24 mg/kg oleuropein groups significantly increased osteoblast cell counts and decreased TRAP‐positive osteoclast and inflammatory cell counts. BMP‐4 and bcl‐2 expressions were elevated in oleuropein groups while caspase‐3 expressions decreased. iNOS and CD68 were higher in periodontitis group compared to control group, but there was no significant difference between other groups. Conclusion Oleuropein successfully decreased alveolar bone loss as a result of decreased osteoclastic activity, inflammation, and apoptosis and increased osteoblastic activity.

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Inos Bmp-4 Cd68 Caspase-3 and Bcl-2 Immunostaining Resmentioning

confidence: 96%

Evaluation of the effect of oleuropein on alveolar bone loss, inflammation, and apoptosis in experimental periodontitis

Taşkan

Yüce

Karataş

et al. 2019

J of Periodontal Research

View full text Add to dashboard Cite

show abstract

“…In addition, it preserved the blood-brain barrier structure and attenuated oxidative stress as well as ICH-induced MAPK activation in brain tissue [238]. Also, Ole improved neurological and cognitive outcomes, alleviated brain edema, increased neurotrophic factors, and reduced apoptosis of neural cells after ischemia/reperfusion injury in rat model of cerebral ischemia [239].…”

Section: Oleuropeinmentioning

confidence: 99%

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

et al. 2019

View full text Add to dashboard Cite

The Mediterranean diet and olive oil as its quintessential part are almost synonymous with a healthy way of eating and living nowadays. This kind of diet has been highly appreciated and is widely recognized for being associated with many favorable effects, such as reduced incidence of different chronic diseases and prolonged longevity. Although olive oil polyphenols present a minor fraction in the composition of olive oil, they seem to be of great importance when it comes to the health benefits, and interest in their biological and potential therapeutic effects is huge. There is a growing body of in vitro and in vivo studies, as well as intervention-based clinical trials, revealing new aspects of already known and many new, previously unknown activities and health effects of these compounds. This review summarizes recent findings regarding biological activities, metabolism and bioavailability of the major olive oil phenolic compounds—hydroxytyrosol, tyrosol, oleuropein, oleocanthal and oleacein—the most important being their antiatherogenic, cardioprotective, anticancer, neuroprotective and endocrine effects. The evidence presented in the review concludes that these phenolic compounds have great pharmacological potential, however, further studies are still required.

show abstract

“…Nevertheless, at moment it's unclear whether OLE affects AQP2-S-glutathionylation. Numerous studies revealed that OLE or oleuropein, which is the main constituent of OLE, may have protective roles by inhibiting cell death 38,39 . However, dose-dependent effects have been described in rats receiving OLE.…”

Section: Discussionmentioning

confidence: 99%

Olive Leaf Extract (OLE) impaired vasopressin-induced aquaporin-2 trafficking through the activation of the calcium-sensing receptor

Ranieri

Mise

Centrone

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Vasopressin (AVP) increases water permeability in the renal collecting duct through the regulation of aquaporin-2 (AQP2) trafficking. Several disorders, including hypertension and inappropriate antidiuretic hormone secretion (SIADH), are associated with abnormalities in water homeostasis. It has been shown that certain phytocompounds are beneficial to human health. Here, the effects of the Olive Leaf Extract (OLE) have been evaluated using in vitro and in vivo models. Confocal studies showed that OLE prevents the vasopressin induced AQP2 translocation to the plasma membrane in MCD4 cells and rat kidneys. Incubation with OLE decreases the AVP-dependent increase of the osmotic water permeability coefficient (Pf). To elucidate the possible effectors of OLE, intracellular calcium was evaluated. OLE increases the intracellular calcium through the activation of the Calcium Sensing Receptor (CaSR). NPS2143, a selective CaSR inhibitor, abolished the inhibitory effect of OLE on AVP-dependent water permeability. In vivo experiments revealed that treatment with OLE increases the expression of the CaSR mRNA and decreases AQP2 mRNA paralleled by an increase of the AQP2-targeting miRNA-137. Together, these findings suggest that OLE antagonizes vasopressin action through stimulation of the CaSR indicating that this extract may be beneficial to attenuate disorders characterized by abnormal CaSR signaling and affecting renal water reabsorption.

show abstract

Protective Effects of Oleuropein Against Cerebral Ischemia/Reperfusion by Inhibiting Neuronal Apoptosis

Cited by 21 publications

References 49 publications

Evaluation of the effect of oleuropein on alveolar bone loss, inflammation, and apoptosis in experimental periodontitis

Evaluation of the effect of oleuropein on alveolar bone loss, inflammation, and apoptosis in experimental periodontitis

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

Olive Leaf Extract (OLE) impaired vasopressin-induced aquaporin-2 trafficking through the activation of the calcium-sensing receptor

Contact Info

Product

Resources

About