Protective effects of oral administration of yeast thioredoxin against gastric mucosal injury

Taketani, Yukiko; Kinugasa, Kimihiro; Kitajima, R.; Nishiumi, Shin; Ashida, Hitoshi; Nakamura, Hajime; Fujita, Takaaki; Kanzaki, Ken; Masutani, Hiroshi; Yodoi, Junji

doi:10.1080/09168451.2014.915733

Cited by 8 publications

(6 citation statements)

References 38 publications

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“…In this context, Girard et al, (2010) demonstrated a dose-dependent gastroprotective effect of Saccharomyces boulardii in a rat model of ibuprofeninduced gastric ulcers, by reducing the number of gastric ulcers and the ulcerated surface of the gastric mucosa. Taketani et al, (2014) showed a gastroprotective effect of orally administered thioredoxin derived from the edible yeast Saccharomyces cerevisiae, in an HCl/ ethanol-induced model. Their results brought forward an interesting possibility of promoting wound-healing responses through the administration of this compound.…”

Section: Discussionmentioning

confidence: 96%

Pretreatment with water kefir reduces the development of acidified ethanol-induced gastric ulcers

Falsoni

Moraes

Rezende

et al. 2022

Braz. J. Pharm. Sci.

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To evaluate the gastroprotective and antioxidant effects of pretreatment with water kefir on ulcers induced with HCl/ethanol. All pretreatments lasted 14 days. Male mice were separated into five groups: the control (C) group received vehicle without ulcer induction; the ulcerated (U) group received vehicle; the lansoprazole (L) group received 30 mg/kg/day lansoprazole; the water kefir (WK15 and WK30) groups received WK at a dose of 0.15 or 0.30 ml/kg/day, respectively. Gastroprotection was measured by ulcer area, ulcer index and ulcer reduction percentage. Antioxidant effects were quantified by measuring advanced oxidized protein products (AOPPs), superoxide dismutase (SOD), and catalase activity in the stomach. Pretreatment with WK at both doses promoted gastroprotection against HCl/ethanol-induced ulcers much like the pretreatment with lansoprazole. In addition, WK decreased protein oxidation while increasing SOD and catalase activity. We concluded that pretreatment with water kefir increases the activity of antioxidant enzymes, preventing gastric lesions induced by HCl/ethanol by maintaining the antioxidant performance in gastric tissue.

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Section: Discussionmentioning

confidence: 96%

Pretreatment with water kefir reduces the development of acidified ethanol-induced gastric ulcers

Falsoni

Moraes

Rezende

et al. 2022

Braz. J. Pharm. Sci.

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“…However, no studies have been conducted to investigate how long orally administered TRX remains in the stomach. Taketani et al demonstrated that orally administered TRX derived from yeast, which is commonly used in fermented foods, has a protective effect on the gastric mucosa both in in vitro and in vivo models (water-immersion restraint stress and HCl/ethanol-induced gastric ulcer models) [ 72 ]. DNA microarray analysis revealed the upregulation of genes related to tissue repair in ulcer regions of rats administered with yeast TRX.…”

Section: Oral Delivery Of Trxmentioning

confidence: 99%

Anti-Inflammatory Thioredoxin Family Proteins for Medicare, Healthcare and Aging Care

et al. 2017

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Human thioredoxin (TRX) is a 12-kDa protein with redox-active dithiol in the active site -Cys-Gly-Pro-Cys-, which is induced by biological stress due to oxidative damage, metabolic dysfunction, chemicals, infection/inflammation, irradiation, or hypoxia/ischemia-reperfusion. Our research has demonstrated that exogenous TRX is effective in a wide variety of inflammatory diseases, including viral pneumonia, acute lung injury, gastric injury, and dermatitis, as well as in the prevention and amelioration of food allergies. Preclinical and clinical studies using recombinant TRX (rhTRX) are now underway. We have also identified substances that induce the expression of TRX in the body, in vegetables and other plant ingredients. Skincare products are being developed that take advantage of the anti-inflammatory and anti-allergic action of TRX. Furthermore, we are currently engaged in the highly efficient production of pure rhTRX in several plants, such as lettuce, grain and rice.

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“…Yeast, such as Saccharomyces boulardii , has been reported to have potential in the treatment and prevention of gastric ulcer induced by ibuprofen in rats ( 51 ). More recently, it was demonstrated using DNA microarray that thioredoxin derived from edible yeast, Saccharomyces cerevisiae , can protect the gastric mucosa by up- or downregulating hundreds of genes involved in the healing of the ulcerative mucosa induced by stress or HCl/ethanol in rats ( 164 ).…”

Section: Prophylactic and Therapeutic Effects Of Probiotics In Gastrimentioning

confidence: 99%

Potential role of probiotics in the management of gastric ulcer

Khoder

Al-Menhali

Al-Yassir

et al. 2016

Experimental and Therapeutic Medicine

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Gastric ulcer is one of the most common chronic gastrointestinal diseases characterized by a significant defect in the mucosal barrier. Helicobacter pylori (H. pylori) infection and the frequent long-term use of non-steroidal anti-inflammatory drugs are major factors involved in gastric ulcer development. Acid inhibitors and antibiotics are commonly used to treat gastric ulcer. However, in the last few decades, the accumulating evidence for resistance to antibiotics and the side effects of antibiotics and acid inhibitors have drawn attention to the possible use of probiotics in the prevention and treatment of gastric ulcer. Probiotics are live microorganisms that when administered in adequate amounts confer health benefits on the host. Currently, the available experimental and clinical studies indicate that probiotics are promising for future applications in the management of gastric ulcers. This review aims to provide an overview of the general health benefits of probiotics on various systemic and gastrointestinal disorders with a special focus on gastric ulcer and the involved cellular and molecular mechanisms: i) Protection of gastric mucosal barrier; ii) upregulation of prostaglandins, mucus, growth factors and anti-inflammatory cytokines; iii) increased cell proliferation to apoptosis ratio; and iv) induction of angiogenesis. Finally, some of the available data on the possible use of probiotics in H. pylori eradication are discussed.

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Protective effects of oral administration of yeast thioredoxin against gastric mucosal injury

Cited by 8 publications

References 38 publications

Pretreatment with water kefir reduces the development of acidified ethanol-induced gastric ulcers

Pretreatment with water kefir reduces the development of acidified ethanol-induced gastric ulcers

Anti-Inflammatory Thioredoxin Family Proteins for Medicare, Healthcare and Aging Care

Potential role of probiotics in the management of gastric ulcer

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