Protective effects of Panax ginseng on muscle injury and inflammation after eccentric exercise

Oliveira, A. C.; Perez, Andréa C.; Merino, Gracia; Prieto, J. E.; Alvarez, Ana I.

doi:10.1016/s1532-0456(01)00262-9

Cited by 77 publications

(44 citation statements)

References 26 publications

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“…Saponin not only has stimulatory effects on the components of specific immunity, but also presents some non-specific immune reactions such as inflammation (de Oliveira et al, 2001;Haridas et al, 2001) and monocyte proliferation (Delmas et al, 2000;Yui et al, 2001). …”

Section: Effects On Immune Systemmentioning

confidence: 99%

Adjuvant effects of saponins on animal immune responses

Rajput

Xiao

et al. 2007

J. Zhejiang Univ. - Sci. B

223

149

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Abstract:Vaccines require optimal adjuvants including immunopotentiator and delivery systems to offer long term protection from infectious diseases in animals and man. Initially it was believed that adjuvants are responsible for promoting strong and sustainable antibody responses. Now it has been shown that adjuvants influence the isotype and avidity of antibody and also affect the properties of cell-mediated immunity. Mostly oil emulsions, lipopolysaccharides, polymers, saponins, liposomes, cytokines, ISCOMs (immunostimulating complexes), Freund's complete adjuvant, Freund's incomplete adjuvant, alums, bacterial toxins etc., are common adjuvants under investigation. Saponin based adjuvants have the ability to stimulate the cell mediated immune system as well as to enhance antibody production and have the advantage that only a low dose is needed for adjuvant activity. In the present study the importance of adjuvants, their role and the effect of saponin in immune system is reviewed.

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Section: Effects On Immune Systemmentioning

confidence: 99%

Adjuvant effects of saponins on animal immune responses

Rajput

Xiao

et al. 2007

J. Zhejiang Univ. - Sci. B

223

149

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“…P. ginseng administration to rats prevented myocardial ischemia-reperfusion damage induced by hyperbaric oxygen (9). Protective effects of P. ginseng against hepatic oxidative stress induced by exhaustive exercise (11) and against muscle injury and inflammation after eccentric exercise (12) have been reported. Ginseng extract has also been reported to scavenge superoxide radicals (13), to inhibit lipid peroxidation through transition metal chelation (7), and to reduce the oxidative DNA damage caused by the Fenton reagent (14).…”

Section: Introductionmentioning

confidence: 96%

Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats

Voces

Oliveira

Prieto

et al. 2004

Braz J Med Biol Res

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Enzymatic activity was analyzed in the soleus, gastrocnemius (red and white) and plantaris muscles of acutely exercised rats after long-term administration of Panax ginseng extract in order to evaluate the protective role of ginseng against skeletal muscle oxidation. Ginseng extract (3, 10, 100, or 500 mg/kg) was administered orally for three months to male Wistar rats weighing 200 ± 50 g before exercise and to non-exercised rats (N = 8/group). The results showed a membrane stabilizing capacity of the extract since mitochondrial function measured on the basis of citrate synthase and 3-hydroxyacyl-CoA dehydrogenase activities was reduced, on average, by 20% (P < 0.05) after exercise but the activities remained unchanged in animals treated with a ginseng dose of 100 mg/kg. Glutathione status did not show significant changes after exercise or treatment. Lipid peroxidation, measured on the basis of malondialdehyde levels, was significantly higher in all muscles after exercise, and again was reduced by about 74% (P < 0.05) by the use of ginseng extract. The administration of ginseng extract was able to protect muscle from exercise-induced oxidative stress irrespective of fiber type. Correspondence

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“…The administration of ginseng to rats has been reported to prevent myocardial ischemia-reperfusion damage induced by hyperbaric oxygen (11). Ginseng has been reported to have protective effects against hepatic oxidative stress caused by exhaustive exercise (12) and against muscle injury and inflammation after eccentric exercise (13). Moreover, it has been reported that ginseng extracts scavenge superoxide radicals, inhibit lipid peroxidation and reduce the level of oxidative DNA damage caused by the Fenton agent (14,15).…”

Section: Introductionmentioning

confidence: 99%

Korean red ginseng protects against neuronal damage induced by transient focal ischemia in rats

Ban

Kang

Lee

et al. 2012

Experimental and Therapeutic Medicine

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Abstract. In the present study, we investigated the neuroprotective effect of Korean red ginseng (KRG) following focal brain ischemia/reperfusion injury, in relation to its antioxidant activities. The middle cerebral artery occlusion/reperfusion (MCAO/R) model in rats was employed. The KRG extract (100 mg/kg, perorally) was administered once daily for 7 days following MCAO/R. The elevated levels of lipid peroxidation in the MCAO/R group were attenuated significantly in the KRG-administered group. The significantly depleted activity of the antioxidant enzymes glutathione peroxidase, superoxide dismutase and catalase was prevented in the KRG-administered group. In the neurobehavioral evaluation expressed as the modified neurological severity score and corner-turn test, the daily intake of KRG showed consistent and significant improvement in the neurological deficits for 7 days following MCAO/R injury. These results indicate that KRG has a neuroprotective effect against ischemia/reperfusion brain injury by reducing the level of lipid peroxidation and increasing the endogenous antioxidant enzymatic activity.

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Protective effects of Panax ginseng on muscle injury and inflammation after eccentric exercise

Cited by 77 publications

References 26 publications

Adjuvant effects of saponins on animal immune responses

Adjuvant effects of saponins on animal immune responses

Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats

Korean red ginseng protects against neuronal damage induced by transient focal ischemia in rats

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