Protective effects of peanut skin extract on high-fat and high-fructose diet-induced kidney injury in rats

Yang, Yang; Yu, Jing; Huo, Jiaoyao; Yang, Luting; Yan, Yaping

doi:10.1007/s10068-023-01250-z

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…Its nephroprotective action was referenced. 74 Yang et al 14 demonstrated that peanut skin extract (PSE) effectively ameliorates kidney damage in rats on a high-fat and high-fructose diet by reducing kidney tissue, perinephric fat weight, and serum ammonia, urea nitrogen, and creatinine levels. Additionally, PSE significantly decreased renal concentrations of TNF-α and IL-1β.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, these color attributes strongly correlate with antioxidant capacity, reinforcing the link between total polyphenols and antioxidant effectiveness . As a source of many bioactive ingredients, the renoprotective effects of peanut skin extracts (PSE) were supported by many studies . Several compounds were identified in grape seed ethanolic extract (GSEE) and peanut skin ethanolic extract (PSEE) with notable physiological activities.…”

Section: Introductionmentioning

confidence: 99%

“…13 As a source of many bioactive ingredients, the renoprotective effects of peanut skin extracts (PSE) were supported by many studies. 14 Several compounds were identified in grape seed ethanolic extract (GSEE) and peanut skin ethanolic extract (PSEE) with notable physiological activities. Gallic acid, with antioxidant, anti-inflammatory, and anticarcinogenic properties, was present at 0.473% in GSEE and 0.019% in PSEE.…”

Section: Introductionmentioning

confidence: 99%

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Mitigating Acetaminophen-Induced Kidney Injury: The Protective Role of Grape Seed and Peanut Skin Extracts through the iNOS/CYP2E1 Pathway

El-Hashash,

Gaballah,

Faramawy

et al. 2024

ACS Omega

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The rising number of acute kidney injury cases worldwide due to acetaminophen (APAP) emphasizes the critical need for effective prevention strategies to counteract APAP's detrimental effects. This study examined the kidney-protective capabilities of ethanolic extracts from grape seeds and peanut skins (GSEE and PSEE, respectively) in comparison with silymarin in rats that experienced an APAP overdose. The phenolic compounds in these extracts were measured by using high-performance liquid chromatography (HPLC). In the experiment, Sixty adult male albino rats were divided into five groups of 12. The Control group received 0.5 mL of saline via a gastric tube. Group II received acetaminophen (APAP, 640 mg/kg per day via a gastric tube) to induce renal injury, following Ucar et al. and Islam et al. Groups III, IV, and V received silymarin (50 mg/ kg), grape seed extract (200 mg/kg), and peanut skin extract (200 mg/kg), respectively, along with 640 mg of APAP/kg per day for 21 days. Post APAP treatment, significant increases in serum urea and creatinine levels were noted, along with notable decreases in the percentage of body weight gain. Furthermore, there were increases in oxidative stress and inflammatory markers in the kidney tissues, including heightened mRNA expressions of renal iNOS and CYP2E1, which were confirmed through histological studies. The administration of GSEE, PSEE, and silymarin mitigated these adverse effects, likely due to their high phenolic content, which is recognized for its antioxidant and anti-inflammatory effects. GSEE, in particular, showed efficacy comparable to that of silymarin. Molecular docking studies revealed that APAP impeded critical enzymes essential for cellular antioxidant defense, whereas the bioactive compounds in the grape seed and peanut skin extracts effectively inhibited key enzymes and receptors involved in inflammation and oxidative stress. These findings suggest that GSEE and PSEE could serve as viable alternative treatments for kidney damage induced by APAP. Further research to isolate and identify these effective compounds is recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%