Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats

Xue, Xiaochang; Wu, Yongjie; Gao, Ming-Tang; Li, Wenguang; Zhao, Ning; Wang, Zenglu; Bao, Chun-Jie; Yan, Zhen; Zhang, Yingqi

doi:10.3748/wjg.v10.i7.1032

Cited by 31 publications

(79 citation statements)

References 26 publications

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“…Due to the recent literary data, the most explored representatives of oligopeptides with gastroprotective properties are met-enkephaline (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) [27,28] and leu-enkephaline (Tyr-Gly-Gly-Phe-Leu) [27][28][29], demorphine (Н-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH 2 ) and sedatine (H-ArgTyr-D-Ala-Phe-Gly-OH) [5,30], pentadecapeptide BPC 157 (GlyGlu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) [10,[31][32][33]; proline-and hydroxyproline-containing products…”

Section: Discussionmentioning

confidence: 99%

“…The protective effect of BPC 157 on the model of acetic ulceration coincided with famotidine, but the effective dose of famotidine (40mg/kg) is 50-fold higher compared to BPC 157 (800 ng/kg). At the same time the effect of BPC 157 caused more significant formation of the granulation tissue in the zone of ulcer defect in contrast to famotidine [31][32][33][34].BPC 157 was reported to exert a regulatory influence on the gastric mucosa through the central nervous system and to regulate the number of G and D cells of the stomach [33]. The other mechanisms of the cytoprotective effect of BPC-157 the authors link to the stimulation of the expression of the early growth gene (EGR-1) and its repressor, binding nervous growth factor 1-А [10,49].…”

mentioning

confidence: 97%

“…Numerous studies reported that high untiulcer and healing effect of the pentadecapeptide BPC 157 of the structure GlyGlu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val on different models of ulceration [9,31,33]. The protective effect of BPC 157 on the model of acetic ulceration coincided with famotidine, but the effective dose of famotidine (40mg/kg) is 50-fold higher compared to BPC 157 (800 ng/kg).…”

Section: Other Oligopeptides With Gastroprotective Propertiesmentioning

confidence: 99%

“…On the example of glypropline of the structure Glu-Pro-Glu, it was shown that this tripeptide was resistant even to the effect of tripeptidases [7,35,36,40]. The pentadecapeptide BPC 157 was also reported to be especially stable and in vitro studies showed that this compound was not broken down by gastric juice during a 24 hours period [10,[31][32][33].Analysis of literary reports on the gastroprotective short peptide compounds we present according the following rubrics:i. neuropeptides ii.…”

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confidence: 99%

“…Oligopeptides were shown to be involved in the regulation of intracellular communication processes, nociception, vessel permeability, neoangiogenesis, nervous impulse transduction as well as affect the activity of hormones and enzymes and exhibit neuro-and immunomodulatory effects [13][14][15][16][17][18][19][20][21]. It is also hypothesized that biological activity of short peptides is mainly associated with their prominent antioxidant properties, although this data is a little bit contradictory as some compounds were reported to have an opposite effect, increasing the processes of oxidation [2,8,16,[24][25][26].Due to the recent literary data, the most explored representatives of oligopeptides with gastroprotective properties are met-enkephaline (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) [27,28] and leu-enkephaline (Tyr-Gly-Gly-Phe-Leu) [27][28][29], demorphine (Н-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH 2 ) and sedatine (H-ArgTyr-D-Ala-Phe-Gly-OH) [5,30], pentadecapeptide BPC 157 (GlyGlu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) [10,[31][32][33]; proline-and hydroxyproline-containing products …”

mentioning

confidence: 99%

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Gastroprotective Oligopeptides

Nasadyuk¹

2015

GHOA

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IntroductionPeptic ulcer disease and its complications still remain a hot issue in modern gastroenterology and one of the constantly important targets for pharmacologic research [1][2][3]. It is commonly acknowledged that nonsteroidal anti-inflammatory drugs (NSAIDs), being the most commonly prescribed group of drugs worldwide for the management of pain and inflammation, play an important role in provoking gastrointestinal tract ulceration, bleeding and perforation [1,4,5]. This mediates the necessity of the effective gastroprotective measures in patients, who are at risk of gastric ulceration, in particular chronic NSAIDs users. Nowadays for this purpose proton pump inhibitors and H 2 -antagonists are commonly used, but due to side effects of these drugs the search for new compounds with gastroprotective properties, suitable for longterm use, remains actual [1,2]. Contemporary literature gives accumulating evidence that a number of oligopeptides play an important role in the regulation of the function of gastrointestinal tract and their synthetic analogues were reported to be effective in the prevention and treatment of gastric ulceration [1,[5][6][7][8][9][10][11][12].That is why the purpose of this review was to summarize the current data on the oligopeptides with documented gastroprotective properties and their possible mechanisms of action. DiscussionDue to the modern outlook, regulatory peptides are considered to be phylogenetically the oldest form of bioregulation [13][14][15][16][17][18][19][20][21]. Thus, the mechanisms of peptidergic regulation of homeostasis open huge perspectives for the creation of the essentially new methods for the prevention and treatment of different diseases [13][14][15][16]. Interestingly, deep studies of the mechanisms of action of regulatory peptides showed that in many cases life-sustaining processes are regulated not by the total peptide molecules but their short-chained derivatives -oligopeptides that are produced in the course of limited proteolysis from proteins-precursors (cytokines, thymic peptides, immunoglobulins) [13,14,18,20,21].The term "oligopeptide" refers to proteins, composed of not more than 20 amino acid residues [22]. For example, it was shown that the inhibition of pancreatic juice secretion by 28-amino acidscontaining hormone ghrelin is realized by its biologically active part -pentapeptide with the sequence of amino acids Gly-Ser-Ser (n-octanoyl)-Phe [23].The advantages of the short peptides above their long-chain derivatives are high biological activity, that often many fold exceeds the activity of the peptide-precursor, high tissue specificity, lack of species specificity and lack of immunogenicity [13,14,[15][16][17][18]20,21]. It was established that low-weighing oligopeptides realize their effect on the cellular, chromosomal, genomic and molecular levels [13][14][15][16][17][18][19][20][21]. The interaction with DNA was proposed to be the key moment of the realization of the biological effect of the short peptides [17][18][19]21]. This concept is s...

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