Protective effects of physical activity in colon cancer and underlying mechanisms: A review of epidemiological and biological evidence

Wang, Tianzhen; Zhang, Ying; Taaffe, Dennis R.; Kim, Jin-Soo; Luo, Hao; Yang, Lirui; Fairman, Ciaran M.; Qiao, Yuandong; Newton, Robert U.; Galvão, Daniel A.

doi:10.1016/j.critrevonc.2022.103578

Cited by 18 publications

(14 citation statements)

References 113 publications

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“…The evidence for muscle-to-organ crosstalk implies a decelerated trajectory toward homeostenosis and frailty, potentially preserving the body's complex responsiveness to continual homeostatic challenges [66 ▪▪ ,67,68 ▪▪ ,69 ▪▪ ,70–73]. As such, routine exercise consistently demonstrates benefit in inflammation reduction, vascular repair and function, circulatory disorders, gastrointestinal health, metabolic and glandular functions, skin healing and function, preservation and diversification of the microbiome, and certain cancer occurrence/recurrence [66 ▪▪ ,67,68 ▪▪ ,69 ▪▪ ,70–77].…”

Section: Physical Activity and Exercise Across The Lifespanmentioning

confidence: 99%

Ageing with Interstitial lung disease: preserving health and well being

Saketkoo

Ndili

Patterson

et al. 2022

Current Opinion in Pulmonary Medicine

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Purpose of reviewAgeing, the accrual of molecular and cellular damage over a lifetime confers progressive physiologic dysfunction of bodily systems, leaving the body in a heightened state of vulnerability to biophysical and psychosocial stressors. The inflection point is frailty which easily leads to disability and death. Interstitial lung disease (ILD) creates biophysical and psychosocial stresses difficult for even optimally fit patients to cope with. With evolving ILD treatment pathways, people with ILD are living longer. Recent findingsILD and ageing are bi-directionally influential: ILD, its treatments, complications, and collateral systemic extra-pulmonary damage (hypoxic and oxidative stress) wear on the ageing person and ageing impacts a person's tolerance of ILD. ILD extent may proportionally accelerate age-related vulnerabilities. ILD related to inflammatory systemic diseases, e.g. connective tissue diseases or sarcoidosis, exert an even more complex biophysical impact on the body.

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Section: Physical Activity and Exercise Across The Lifespanmentioning

confidence: 99%

Ageing with Interstitial lung disease: preserving health and well being

Saketkoo

Ndili

Patterson

et al. 2022

Current Opinion in Pulmonary Medicine

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“…The authors declare no conflict of interest. Samuel T. Orange 1,2 Alastair R. Jordan 3 Adam Odell 3 Owen Kavanagh 3 Kirsty M. Hicks 4 Stephen Todryk 5 John M. Saxton 4,6 Abbreviations: DNA, deoxyribonucleic acid; IL, interleukin; TNF-α, tumour necrosis factoralpha.…”

Section: Conflict Of Interestmentioning

confidence: 99%

“…2 We employed a targeted approach (immunoassays) to quantify exercise-induced changes in the serum concentration of seven cytokines, including IL-6, IL-8, IL-10, tumour necrosis factor-alpha (TNF-α), irisin, osteonectin and oncostatin M, which were chosen based on previous research implicating them with exercise and cancer regression. 6 Of these cytokines, only serum IL-6 concentration significantly changed from pre to post acute exercise. 2 Of course, this is not an exhaustive list of molecules that are modulated by acute exercise.…”

mentioning

confidence: 95%

Reply to “Comments on: Acute aerobic exercise‐conditioned serum reduces colon cancer cell proliferation in vitro through interleukin‐6‐induced regulation of DNA damage”

Orange

Jordan

Odell

et al. 2022

Intl Journal of Cancer

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“…The most promising strategy to promote lean mass gain in cachexia is resistance training. Moreover, several clinical studies suggest that exercise slows the progression of various forms of cancer and increases the survival of cancer patients by reducing the risk of recurrence [11]. Exercise training decreases the expression of proinflammatory factors, including myostatin [12], tumour necrosis factor, and interleukin (IL)-6 [13,14] in skeletal muscle cells.…”

Section: Introductionmentioning

confidence: 99%

Physiactisome: A New Nanovesicle Drug Containing Heat Shock Protein 60 for Treating Muscle Wasting and Cachexia

Felice

Barone

Trovato

et al. 2022

Cells

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Currently, no commercially available drugs have the ability to reverse cachexia or counteract muscle wasting and the loss of lean mass. Here, we report the methodology used to develop Physiactisome—a conditioned medium released by heat shock protein 60 (Hsp60)—overexpressing C2C12 cell lines enriched with small and large extracellular vesicles. We also present evidence supporting its use in the treatment of cachexia. Briefly, we obtain a nanovesicle-based secretion by genetically modifying C2C12 cell lines with an Hsp60-overexpressing plasmid. The secretion is used to treat naïve C2C12 cell lines. Physiactisome activates the expression of PGC-1α isoform 1, which is directly involved in mitochondrial biogenesis and muscle atrophy suppression, in naïve C2C12 cell lines. Proteomic analyses show Hsp60 localisation inside isolated nanovesicles and the localisation of several apocrine and merocrine molecules, with potential benefits for severe forms of muscle atrophy. Considering that Physiactisome can be easily obtained following tissue biopsy and can be applied to autologous muscle stem cells, we propose a potential nanovesicle-based anti-cachexia drug that could mimic the beneficial effects of exercise. Thus, Physiactisome may improve patient survival and quality of life. Furthermore, the method used to add Hsp60 into nanovesicles can be used to deliver other drugs or active proteins to vesicles.

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Protective effects of physical activity in colon cancer and underlying mechanisms: A review of epidemiological and biological evidence

Cited by 18 publications

References 113 publications

Ageing with Interstitial lung disease: preserving health and well being

Ageing with Interstitial lung disease: preserving health and well being

Reply to “Comments on: Acute aerobic exercise‐conditioned serum reduces colon cancer cell proliferation in vitro through interleukin‐6‐induced regulation of DNA damage”

Physiactisome: A New Nanovesicle Drug Containing Heat Shock Protein 60 for Treating Muscle Wasting and Cachexia

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