Protective Effects of Pinocembrin and Pinostrobin against Hydrogen Peroxide-Induced Stress in Retina Pigment Epithelial Cells

Kılıçaslan, Derya; Kurt, Akif Hakan; Doğaner, Adem

doi:10.1007/s11094-020-02275-y

Cited by 1 publication

(1 citation statement)

References 46 publications

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“…On the other hand, in the study done by García Forero, et al [20] , pinocembrin was reported to not only display maximum wavelength absorption within the UVC and UVB range but also increased the SPF in vitro values and inhibited DNA damage in both E. coli PQ37 strain and human embryo kidney (HEK-293) cells. Other studies on pinocembrin also displayed that the compound is able to inhibit oxidative stress in retinal pigment epithelium and inhibit the activation of nuclear factor (NF)-κB, degradation of IκB, and expression matrix metalloprotease (MMP)-1, 3, and 13 in human chondrocytes [21,22] . Although these two studies are not directly conducted on skin models, the cascade of UVB photoaging is also triggered by similar markers as described by Mahendra, et al [17] , hence, suggesting that pinocembrin might potentially be able to suppress photodamage.…”

Section: ∫ 𝐴(𝜆)𝑑𝜆mentioning

confidence: 98%

Simplified, Cost Effective, and Accurate Calculation of Critical Wavelength via the MATLAB Software

Mahendra¹,

Mahendra²,

Pusparajah³

et al. 2021

Prog Drug Discov Biomed Sci

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The use of sunscreens in our daily lives to reduce UV exposure on our skin is a good measure against photoaging. However, the current active ingredients in the market are not able to cover the entire spectrum range of UVA and UVB. Therefore, broader spectrum compounds are constantly being searched by cosmetic companies to replace the commercially available UV filters. In this study, an experimental model utilizing the MATLAB software was developed to measure a compound’s critical wavelength (λc). The purpose of this research was to ease the cost and speed up the screening of bioactive compounds for photoprotective properties while maintaining accuracy in the process. In this paper, the measurement of caffeic acid, gallic acid, and pinocembrin’s critical wavelength in the MATLAB software was explained in a step-by-step guide. This was done to create an understandable and executable procedure for future researchers to utilize. Subsequently, from the results, the critical wavelength of caffeic acid, gallic acid, and pinocembrin was 378.2nm, 324.6nm, and 364.8nm, respectively. This shows that caffeic acid has the broadest absorbance spectrum, followed by pinocembrin, and finally gallic acid. Thus, it may be possible that caffeic acid might have stronger photoprotective abilities as compared to pinocembrin and gallic acid, based on its critical wavelength.

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