Protective effects of piperlongumin in the prevention of inflammatory damage caused by pulmonary exposure to benzopyrene carcinogen

Ashino, Tissiane Eid Barbosa; Ana, Monielle Leal Sant; Yoshikawa, Ariane Harumi; Possebon, Lucas; Costa, Sara de Souza; Iyomasa-Pilon, Melina Mizusaki; Souza, Helena Ribeiro; Gonçalves, Giovana Aparecida; Oliani, Sônia Maria; Girol, Ana Paula

doi:10.1016/j.intimp.2021.108285

Cited by 5 publications

(2 citation statements)

References 63 publications

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“…28,29 Piperlongumine has therapeutic potential in the treatment of lung anti-inflammatory and antitumor diseases. [30][31][32] In our study, overall levels of TNF-α, IL-1β, and IL-6 were significantly increased in serum from SAP model rats compared with those in the control group. More importantly, after treatment with piperlonguminine (10 mg/kg body weight) these increases in cytokines Article were partially attenuated in SAP rats.…”

Section: Discussionsupporting

confidence: 51%

Effects of piperlonguminine on lung injury in severe acute pancreatitis <em>via</em> the TLR4 /NF-κB pathway

Tao

et al. 2023

Eur J Histochem

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Acute pancreatitis is an inflammatory response in the pancreas, involving activation of pancreatic enzymes. Severe acute pancreatitis (SAP) often causes systemic complications that affect distant organs, including the lungs. The aim of this study was to explore the therapeutic potential of piperlonguminine on SAP-induced lung injury in rat models. Acute pancreatitis was induced in rats by repetitive injections with 4% sodium taurocholate. Histological examination and biochemical assays were used to assess the severity of lung injury, including tissue damage, and levels of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4), reactive oxygen species (ROS), and inflammatory cytokines. We found that piperlonguminine significantly ameliorated pulmonary architectural distortion, hemorrhage, interstitial edema, and alveolar thickening in rats with SAP. In addition, NOX2, NOX4, ROS, and inflammatory cytokine levels in pulmonary tissues were notably decreased in piperlonguminine-treated rats. Piperlonguminine also attenuated the expression levels of toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB). Together, our findings demonstrate for the first time that piperlonguminine can ameliorate acute pancreatitis-induced lung injury via inhibitory modulation of inflammatory responses by suppression of the TLR4/NF-κB signaling pathway.

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Section: Discussionsupporting

confidence: 51%

Effects of piperlonguminine on lung injury in severe acute pancreatitis <em>via</em> the TLR4 /NF-κB pathway

Tao

et al. 2023

Eur J Histochem

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“…BaP, as a representative of PAHs, is a carcinogen, and intake of tiny amounts of BaP may alter the body's DNA bases, causing malignant transformation of cells and inducing tumors. 40 Tet antibiotics are a common class of antibiotics that have long been widely used in the agricultural industry as veterinary drugs and growth promoters, inducing the production of Tet-resistant microorganisms in the environ-ment and potentially increment of antibiotic-resistant infections in clinical settings, and therefore threaten human and animal health. 41 Monitoring these toxic components and antibiotics in natural environments is of paramount importance.…”

Section: Design and Construction Of The Modular Geneticmentioning

confidence: 99%

Engineering Modular and Highly Sensitive Cell-Based Biosensors for Aromatic Contaminant Monitoring and High-Throughput Enzyme Screening

et al. 2023

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Although a variety of whole-cell-based biosensors have been developed for different applications in recent years, most cannot meet practical requirements due to insufficient sensing performance. Here, we constructed two sets of modular genetic circuits by serial and parallel modes capable of significantly amplifying the input/output signal in Escherichia coli. The biosensors are engineered using σ 54 -dependent phenol-responsive regulator DmpR as a sensor and enhanced green fluorescent protein as a reporter. Cells harboring serial and parallel genetic circuits displayed nearly 9-and 16-fold higher sensitivity than the general circuit. The genetic circuits enabled rapid detection of six phenolic contaminants in 12 h and showed the low limit of detection of 2.5 and 2.2 ppb for benzopyrene (BaP) and tetracycline (Tet), with a broad detection range of 0.01−1 and 0.005−5 μM, respectively. Furthermore, the positive rate was as high as 73% when the biosensor was applied to screen intracellular enzymes with esterhydrolysis activity from soil metagenomic libraries using phenyl acetate as a phenolic substrate. Several novel enzymes were isolated, identified, and biochemically characterized, including serine peptidases and alkaline phosphatase family protein/metalloenzyme. Consequently, this study provides a new signal amplification method for cell-based biosensors that can be widely applied to environmental contaminant assessment and screening of intracellular enzymes.

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Construction of novel magnetic nanoparticles for enrichment of benzo(α)pyrene from edible oils followed by HPLC determination

Sun

et al. 2022

Food Chemistry

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Protective effects of piperlongumin in the prevention of inflammatory damage caused by pulmonary exposure to benzopyrene carcinogen

Cited by 5 publications

References 63 publications

Effects of piperlonguminine on lung injury in severe acute pancreatitis <em>via</em> the TLR4 /NF-κB pathway

Effects of piperlonguminine on lung injury in severe acute pancreatitis <em>via</em> the TLR4 /NF-κB pathway

Engineering Modular and Highly Sensitive Cell-Based Biosensors for Aromatic Contaminant Monitoring and High-Throughput Enzyme Screening

Construction of novel magnetic nanoparticles for enrichment of benzo(α)pyrene from edible oils followed by HPLC determination

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