Protective effects of quercetin against phenylhydrazine-induced vascular dysfunction and oxidative stress in rats

Luangaram, Saowanee; Kukongviriyapan, Upa; Pakdeechote, Poungrat; Kukongviriyapan, Veerapol; Pannangpetch, Patchareewan

doi:10.1016/j.fct.2006.09.008

Cited by 89 publications

(70 citation statements)

References 51 publications

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“…As PHZ action is of short half life and measurement of hemodynamics and vascular reactivity was performed 48 h after ad- ministration of PHZ, it is likely that PHZ induces hypotension and vascular dysfunction are intensified by oxidant species and inflammatory mediators released from the inflammatory cells. 26,41) This suggestion is consistent with our findings that there was a large flux of O 2 ·Ϫ from blood cells. Moreover, a marked increase in NOx levels may be primarily due to the activation of monocytes.…”

Section: Discussionsupporting

confidence: 93%

Antioxidant and Vascular Protective Activities of Cratoxylum formosum, Syzygium gratum and Limnophila aromatica

Kukongviriyapan

Luangaram

Leekhaosoong

et al. 2007

Biological & Pharmaceutical Bulletin

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Section: Discussionsupporting

confidence: 93%

Antioxidant and Vascular Protective Activities of Cratoxylum formosum, Syzygium gratum and Limnophila aromatica

Kukongviriyapan

Luangaram

Leekhaosoong

et al. 2007

Biological & Pharmaceutical Bulletin

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“…The phenolic compounds such as quercetin and catechins present in the CAE may have different functional property such as scavenging of ROS (Hatano et al, 1989;Zainol et al, 2003), inhibition of the generation of free radicals and chain-breaking activity (Laranjinha et al, 1995). They may act as hydrogendonating radical scavengers by scavenging lipid alkoxyl and peroxyl radical and spares overall antioxidant status (Bors et al -avanoids and triterpenes exerts free radical scavenging, membrane stabilizing, iron-chelating, lipotrophic, vasoac--ry, anti-apoptotic, anti-ageing and neuroprotective effects and increases cytoprotective heat shock proteins (Lahouel et al, 2006;Broncel et al, 2007;Greenrod et al, 2005;Kalfon et al, 2007;Mo et al, 2007;Luangaram et al, 2007). Thus the observed free radical scavenging and antioxidant effect of C asiatica in the present study could be attributed to the triterpenes and phenolic content of the whole plant.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced parkinsonism in aged Sprague-Dawley rats

2010

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-Reactive oxygen species (ROS) play an important role in ageing and age-related neurodegenerative changes including Parkinson's disease (PD). PD is characterized by signs of major oxidative stress and mitochondrial damage in the pars compacta of the substantia nigra. Present study was designed to investigate whether the Centella asiatica extract (CAE) would prevent 1-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine (MPTP) -induced neurotoxicity in aged Sprague-Dawley rats. Adult, male Sprague-dawley rats of 300-350 g were divided into control, C. asiatica alone, MPTP alone (20 mg/kg, for 21 days) and MPTP with C. asiatica (300 mg/kg for 21 days) groups. Effect of aqueous extract of C. asiatica on oxidative biomarker levels in corpus striatum and hippocampus homogenate was examined. MPTP-chal---asiatica was effective in protecting the brain against neurodegenerative disorders such as Parkinsonism.

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“…Subsequently, the total protein concentration of the testicular supernatant was measured using a NanoDrop ND-1000 Spectrophotometer at absorbance of 280 nm. For testicular lysate, the concentration of testicular MDA was measured by TBARS assay as applied from Luangaram et al (2007). Briefly, testicular lysate was mixed with TBARS reagents.…”

Section: Testicular Malondialdehyde (Mda) Level Measurementmentioning

confidence: 99%

Protective Effect of Momordica cochinchinensis (L.) Spreng Aril Extract on Essential Testicular Markers in Rats Induced with Valproic Acid

et al. 2017

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SITTHICHAI, I.; WANNISA, S.; APICHAKARN, S. & BUNGORN, S.Protective effect of Momordica cochinchinensis (L.) spreng aril extract on essential testicular markers in rats induced with valproic acid. Int. J. Morphol., 35(3):992-999, 2017. SUMMARY:Valproic acid (VPA), an anti-epileptic drug, has been reported to cause male sub/infertility. Together with searching for alternative treatments, the degrees to which testosterone levels and sperm quality are decreased under VPA treatment also need to be clarified. This study aimed to investigate the protective effects of Momordica cochinchinensis (MC) aril extract containing antioxidant capacity on adverse reproductive parameters induced with VPA. Rats were divided into 6 groups (control, VPA, 200 mg kg-1 of MC only, 50, 100, 200 mg kg-1 MC+VPA, respectively, n=8 in each). Animals were pretreated with MC extract for 23 days before coadministration with VPA (500 mg kg-1, i.p.) for 10 consecutive days. All reproductive parameters including histology, and expression of androgen receptor (AR), Ki-67, tyrosine phosphorylated proteins, and steroidogenic proteins in testis were examined. The results showed that MC could prevent all reproductive parameters in VPA-treated rats. Moreover, MC+VPA groups showed significant declining of testicular histopathologies compared to VPA group. It also decreased the malondialdehyde level and changes of the testicular StAR, AR, and tyrosine phosphorylated protein expressions. In conclusion, M. cochinchinensis aril extract can prevent adverse male reproductive parameters and essential testicular proteins damages induced with VPA.

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Protective effects of quercetin against phenylhydrazine-induced vascular dysfunction and oxidative stress in rats

Cited by 89 publications

References 51 publications

Antioxidant and Vascular Protective Activities of Cratoxylum formosum, Syzygium gratum and Limnophila aromatica

Antioxidant and Vascular Protective Activities of Cratoxylum formosum, Syzygium gratum and Limnophila aromatica

Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced parkinsonism in aged Sprague-Dawley rats

Protective Effect of Momordica cochinchinensis (L.) Spreng Aril Extract on Essential Testicular Markers in Rats Induced with Valproic Acid

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