Protective effects of quercetin against brain injury in a rat model of lipopolysaccharide‐induced fetal brain injury

Wang, Qian; Liu, Cong

doi:10.1016/j.ijdevneu.2018.09.008

Cited by 12 publications

(5 citation statements)

References 33 publications

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“…Several bioactive components of the mixture could act as HAT inhibitors, thus contributing to the observed neuroprotective effect. Besides EGCG, among the compounds present at higher concentrations, quercetin and LA inhibit p300/CBP [33,34] and have been reported to exert neuroprotective effects in cellular and animal models of brain ischemia [17,18,19,20,21,35,36,37,38,39,40,41]. Therefore, one of the possible mechanisms involved in the RelA regulation could very well be the inhibition of p300/CBP by PMM (Figure 5).…”

Section: Discussionmentioning

confidence: 99%

A Polyphenol-Enriched Supplement Exerts Potent Epigenetic-Protective Activity in a Cell-Based Model of Brain Ischemia

et al. 2019

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Bioactive components, due in part to their epigenetic properties, are beneficial for preventing several human diseases including cerebrovascular pathologies. However, no clear demonstration supports the idea that these molecules still conserve their epigenetic effects when acting at very low concentrations reproducing the brain levels achieved after oral administration of a micronutrient supplement. In the present study, we used a cellular model of brain ischemia to investigate the neuroprotective and epigenetic activities of a commercially available micronutrient mixture (polyphenol-enriched micronutrient mixture, PMM) enriched in polyphenols ((-)-epigallocatechin-3-gallate, quercetin, resveratrol), α-lipoic acid, vitamins, amino acids and other micronutrients. Mimicking the suggested dietary supplementation, primary cultures of mouse cortical neurons were pre-treated with PMM and then subjected to oxygen glucose deprivation (OGD). Pre-treatment with PMM amounts to provide bioactive components in the medium in the nanomolar range potently prevented neuronal cell death. The protection was associated with the deacetylation of the lysin 310 (K310) on NF-κB/RelA as well as the deacetylation of H3 histones at the promoter of Bim, a pro-apoptotic target of ac-RelA(K310) in brain ischemia. Epigenetic regulators known to shape the acetylation state of ac-RelA(K310) moiety are the histone acetyl transferase CBP/p300 and the class III histone deacetylase sirtuin-1. In view of that evidence, the protection we here report unveils the efficacy of bioactive components endowed with either inhibitory activity on CBP/p300 or stimulating activity on the AMP-activated protein kinase–sirtuin 1 pathway. Our results support a potential synergistic effect of micronutrients in the PMM, suggesting that the intake of a polyphenol-based micronutrient mixture can reduce neuronal vulnerability to stressful conditions at concentrations compatible with the predicted brain levels reached by a single constituent after an oral dose of PMM.

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Section: Discussionmentioning

confidence: 99%

A Polyphenol-Enriched Supplement Exerts Potent Epigenetic-Protective Activity in a Cell-Based Model of Brain Ischemia

et al. 2019

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“…In Wistar rats, quercetin successfully alleviated fetal brain damage induced by maternal exposure to LPS. In brain tissue of newborn rats, quercetin attenuated the release of pro-inflammatory cytokines IL-1β, IL-6 and TNF-α, suppressed LPS-induced apoptosis by preserving the Bax/Bcl-2 ratio and exerted anti-oxidative effects by reducing MDA levels and by increasing catalase activity and the GSH content [232].…”

Section: Quercetinmentioning

confidence: 97%

Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration

et al. 2021

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Neurodegenerative diseases are one of the leading causes of disability and death worldwide. Intracellular transduction pathways that end in the activation of specific transcription factors are highly implicated in the onset and progression of pathological changes related to neurodegeneration, of which those related to oxidative stress (OS) and neuroinflammation are particularly important. Here, we provide a brief overview of the key concepts related to OS- and neuroinflammation-mediated neuropathological changes in neurodegeneration, together with the role of transcription factors nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor-κB (NF-κB). This review is focused on the transcription factor p53 that coordinates the cellular response to diverse genotoxic stimuli, determining neuronal death or survival. As current pharmacological options in the treatment of neurodegenerative disease are only symptomatic, many research efforts are aimed at uncovering efficient disease-modifying agents. Natural polyphenolic compounds demonstrate powerful anti-oxidative, anti-inflammatory and anti-apoptotic effects, partially acting as modulators of signaling pathways. Herein, we review the current understanding of the therapeutic potential and limitations of flavonols in neuroprotection, with emphasis on their anti-oxidative, anti-inflammatory and anti-apoptotic effects along the Nrf2, NF-κB and p53 pathways. A better understanding of cellular and molecular mechanisms of their action may pave the way toward new treatments.

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“…UTI) on brain development, but some evidence suggests that dampening pathogen-induced inflammation during pregnancy may mitigate neurodevelopmental abnormalities in offspring. [212][213][214][215] The alternative, namely not treating a bacterial infection with antibiotics, is simply not an option as this could lead to bacterial dissemination and sepsis with even worse outcomes for the mother and fetus. Overall, investigation of the role of antiinflammatory drugs with and without antibiotic therapy coupled with fetal outcome remains a significant research gap.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

The fetal origins of mental illness

al-Haddad

Oler

Armistead

et al. 2019

American Journal of Obstetrics and Gynecology

225

142

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Protective effects of quercetin against brain injury in a rat model of lipopolysaccharide‐induced fetal brain injury

Cited by 12 publications

References 33 publications

A Polyphenol-Enriched Supplement Exerts Potent Epigenetic-Protective Activity in a Cell-Based Model of Brain Ischemia

A Polyphenol-Enriched Supplement Exerts Potent Epigenetic-Protective Activity in a Cell-Based Model of Brain Ischemia

Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration

The fetal origins of mental illness

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