Protective effects of quercetin-loaded microcapsules on the enteric nervous system of diabetic rats

Sehaber-Sierakowski, Camila Cavicchioli; Vieira-Frez, Flávia Cristina; Hermes-Uliana, Catchia; Martins, Heber Amilcar; Bossolani, Gleison Daion Piovezana; Lima, Mariana Machado; Blegniski, Fernanda Paschoal; Guarnier, Flávia Alessandra; Baracat, Marcela M.; Perles, Juliana Vanessa Colombo Martins; Zanoni, Jacqueline Nelisis

doi:10.1016/j.autneu.2020.102759

Cited by 12 publications

(3 citation statements)

References 54 publications

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“…The most common carotenoids such as β-carotene, lutein, crocin, lycopene, zeaxanthin, and curcumin have antioxidants and anti-inflammatory properties in the management of neurodegenerative disorders [74,75].…”

Section: Association Between Carotenoid Intake and Obesity And Diabetesmentioning

confidence: 99%

Role of antioxidants as immunity booster in obesity and diabetes: a systematic review on neuro-gliopathies perspective

Sharma,

Sharma

2024

Explor Neurosci

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Background: The main objective of the study was to carry out a systematic literature review to investigate the beneficial role of antioxidants in obesity and diabetes and the association of antioxidants in neuro-gliopathies and gut microbiome on antioxidant production and enteric nervous system (ENS) protection. Methods: A literature search was done electronically on 8 June 2022 in the databases Google Scholar, and PubMed, reviewing all the articles published in English. There were no limitations for the study (region, or any time frame). The study included randomized controlled trials (RCTs) and observational studies on a human subject, primarily focusing on information such as a change in body weight, body mass index (BMI), waist-to-height ratio (WHtR), waist-to-hip ratio (WHR), fasting blood glucose level, glycated haemoglobin (HbA1c), and other parameters that connected with diabetes and obesity. The search was also conducted for neuro-gliopathies and gut microbiome. Results: The beginning database search picked out a total of 2,428 articles, 1,310 in PubMed, 876 in Google Scholar, and 242 records from other sources. A total of 2,040 (total duplicates 388) was found after removing the duplicated articles, and after reading the title and abstracts were further decreased to 139 full-text articles. These 139 studies went for full-text analysis, which resulted in the exclusion of 123 studies and generated a final 16 articles included for systemic analysis. Discussion: This literature search of present studies shows the interconnection between antioxidant intake among obese and diabetes neuro-gliopathies. The findings indicate both obese and diabetic patients have a minimum content of antioxidants, especially carotenoids, retinol, ascorbic acid, tocopherol, magnesium, and zinc. While few research illustrated that ingestion of the abovementioned antioxidants was lowered among diabetes and obese subjects in contrast with their normal-weight population, this was not endorsed by every study.

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Section: Association Between Carotenoid Intake and Obesity And Diabetesmentioning

confidence: 99%

Role of antioxidants as immunity booster in obesity and diabetes: a systematic review on neuro-gliopathies perspective

Sharma,

Sharma

2024

Explor Neurosci

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“…The decline in vascular tone is probably linked to the modulation of the expression of cyclooxygenase (COX) and COX-derived vasoconstrictive agents via a mechanism that involves the NF-κB pathway. The vasoprotective effect of the dietary supplementation of red vine polyphenols is also associated with a reduction in the release of vasoconstrictive factors such as thromboxane-A2 and 8-isporostone [61,62].…”

Section: Red Winementioning

confidence: 99%

Biological Potential of Polyphenols in the Context of Metabolic Syndrome: An Analysis of Studies on Animal Models

Niewiadomska

Gajek-Marecka

Gajek

et al. 2022

Biology

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Metabolic syndrome (MetS) is a disease that has a complex etiology. It is defined as the co-occurrence of several pathophysiological disorders, including obesity, hyperglycemia, hypertension, and dyslipidemia. MetS is currently a severe problem in the public health care system. As its prevalence increases every year, it is now considered a global problem among adults and young populations. The treatment of choice comprises lifestyle changes based mainly on diet and physical activity. Therefore, researchers have been attempting to discover new substances that could help reduce or even reverse the symptoms when added to food. These attempts have resulted in numerous studies. Many of them have investigated the bioactive potential of polyphenols as a “possible remedy”, stemming from their antioxidative and anti-inflammatory effects and properties normalizing carbohydrate and lipid metabolism. Polyphenols may be supportive in preventing or delaying the onset of MetS or its complications. Additionally, the consumption of food rich in polyphenols should be considered as a supplement for antidiabetic drugs. To ensure the relevance of the studies on polyphenols’ properties, mechanisms of action, and potential human health benefits, researchers have used laboratory animals displaying pathophysiological changes specific to MetS. Polyphenols or their plant extracts were chosen according to the most advantageous mitigation of pathological changes in animal models best reflecting the components of MetS. The present paper comprises an overview of animal models of MetS, and promising polyphenolic compounds whose bioactive potential, effect on metabolic pathways, and supplementation-related benefits were analyzed based on in vivo animal models.

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“…This derivative was suggested for the prevention of Alzheimer's disease. The effect of quercetin-loaded microcapsules was analyzed for neuroprotective properties in Wistar adult rats by studying nitrergic neurons reducing oxidative damage [75]. In a comparative study by Jalili-Baleh et al [76], quercetin was chosen as the standard for a neuroprotective activity for chromone-lipoic acid hybrids.…”

Section: Quercetin As a Neuroprotective Agentmentioning

confidence: 99%

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products

Bhat

2021

Biology

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Quercetin, a bioactive secondary metabolite, holds incredible importance in terms of bioactivities, which has been proved by in vivo and in vitro studies. The treatment of cardiovascular and neurological diseases by quercetin has been extensively investigated over the past decade. Quercetin is present naturally in appreciable amounts in fresh produce (fruits and vegetables). However, today, corresponding to the growing population and global demand for fresh fruits and vegetables, a paradigm shift and focus is laid towards exploring industrial food wastes and/or byproducts as a new resource to obtain bioactive compounds such as quercetin. Based on the available research reports over the last decade, quercetin has been suggested as a reliable therapeutic candidate for either treating or alleviating health issues, mainly those of cardiovascular and neurological diseases. In the present review, we have summarized some of the critical findings and hypotheses of quercetin from the available databases foreseeing its future use as a potential therapeutic agent to treat cardiovascular and neurological diseases. It is anticipated that this review will be a potential reference material for future research activities to be undertaken on quercetin obtained from fresh produce as well as their respective processing wastes/byproducts that rely on the circular concept.

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Protective effects of quercetin-loaded microcapsules on the enteric nervous system of diabetic rats

Cited by 12 publications

References 54 publications

Role of antioxidants as immunity booster in obesity and diabetes: a systematic review on neuro-gliopathies perspective

Role of antioxidants as immunity booster in obesity and diabetes: a systematic review on neuro-gliopathies perspective

Biological Potential of Polyphenols in the Context of Metabolic Syndrome: An Analysis of Studies on Animal Models

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products

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