Protective Effects of Quercetin on Necrotizing Enterocolitis in a Neonatal Rat Model

Yazıcı, Selçuk; Ozcan, Cansu Unden; Hişmioğulları, Adnan Adil; Sunay, Fatma Bahar; Ozcan, Teoman; Berksoy, Emel; Aksöz, Elif

doi:10.1055/s-0037-1608660

Cited by 16 publications

(3 citation statements)

References 26 publications

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“…Numerous studies have shown that quercetin has the potential to treat other diseases, such as necrotizing enterocolitis (NEC), diabetes, and lung injury. In NEC, quercetin modulates the total antioxidant status by regulating serum levels of MDA and GSH [101]. In type II diabetes, a study found that quercetin intake was inversely related to the prevalence of diabetes [102].…”

Section: Application Of Antioxidant Activity In the Medicinal Fieldmentioning

confidence: 99%

Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application

et al. 2019

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Quercetin is a bioactive compound that is widely used in botanical medicine and traditional Chinese medicine due to its potent antioxidant activity. In recent years, antioxidant activities of quercetin have been studied extensively, including its effects on glutathione (GSH), enzymatic activity, signal transduction pathways, and reactive oxygen species (ROS) caused by environmental and toxicological factors. Chemical studies on quercetin have mainly focused on the antioxidant activity of its metal ion complexes and complex ions. In this review, we highlight the recent advances in the antioxidant activities, chemical research, and medicinal application of quercetin.

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Section: Application Of Antioxidant Activity In the Medicinal Fieldmentioning

confidence: 99%

Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application

et al. 2019

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“…Other disease conditions like necrotising enterocolitis (NEC), respiratory infections may be treated with quercetin. By lowering the level of oxidative stress biomarkers and enhancing antioxidant enzyme activity, it protects against acute lung injury [23]. respiratory illnesses.…”

Section: Therapeutic Applications Of Quercetinmentioning

confidence: 99%

Quercetin nanoformulations: recent advancements and therapeutic applications

Kaur,

Goyal,

Rai

et al. 2023

Adv. Nat. Sci: Nanosci. Nanotechnol.

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Quercetin is a natural bioflavonoid and is an inevitable part of a person’s daily diet. It exhibits anti-inflammatory, anti-oxidant, anti-cancer, anti-microbial effects and is used for the treatment of several diseases like cancer, cardiovascular ailments, and microbial infections. The major limitations of quercetin are low water solubility, less chemical stability, low bioavailability, and short biological half-life. All these major drawbacks can be overcome by its encapsulation in various nanocarriers (nanoparticles, nanoliposomes, nanocrystals, nanomicelles, etc). Such quercetin encapsulated nanoformulations displayed enhanced solubility, stability, bioavailability, high encapsulation efficiency, controlled drug release and extended systemic circulation time period. Quercetin loaded nanocarriers can easily pass across different barriers like blood brain barrier (BBB), skin barriers, mucosal membrane, hence providing target site specific delivery. They also exhibited improved therapeutic effects such as enhanced anti-cancer, anti-diabetic, anti-microbial, anti-inflammatory, anti-psoriasis, anti-oxidant, anti-asthmatic, anti-acne, skin-whitening, hepatoprotective, photoprotective, neuroprotective, nephroprotective and cardioprotective actions. Major health issues associated with nanoformulations are risk of cytotoxicity, oxidative stress, DNA damage, and mutations that can be minimised with continual advancements in nanotechniques. The present review discusses quercetin, its historical background, pharmacokinetics, mechanism of action, and therapeutic applications with major emphasis on the quercetin nanoformulations such as nanoparticles, nanoemulsions, nanoliposomes, nanocrystals, nanosuspensions and nanomicelles that enhances its physicochemical stability, solubility, and therapeutic applications. Also this review includes different quercetin nanoformulations developed for colon cancer and colorectal cancer treatment, brief description of pre-clinical & clinical studies, toxicological concerns, challenges & opportunities, future aspects, patents and marketed quercetin products.

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“…Here, we summarize the recent studies that have evaluated the biological and pharmacological activities of quercetin (Table 1 (Tab. 1) ; References in Table 1: Abdelhalim et al, 2018[ 1 ]; Afifi et al, 2018[ 2 ]; Aghapour et al, 2018[ 3 ]; Ahmed et al, 2018[ 4 ]; Al-Asmari et al, 2018[ 5 ]; Ansar et al, 2016[ 7 ]; Atef et al, 2017[ 8 ]; Beghoul et al, 2017[ 9 ]; Calgarotto et al, 2018[ 11 ]; Chan et al, 2018[ 12 ]; Chang et al, 2017[ 13 ]; Chen et al, 2017[ 14 ]; Damiano et al, 2018[ 16 ]; Dong et al, 2017[ 17 ]; Duranti et al, 2018[ 18 ]; Esrefoglu et al, 2017[ 20 ]; Funakoshi et al, 2017[ 22 ]; Guo et al, 2017[ 23 ]; He et al, 2016[ 24 ]; Huang et al, 2017[ 25 ]; Jeon et al, 2017[ 26 ]; Ji et al, 2017[ 27 ]; Ju et al, 2018[ 28 ]; Kee et al, 2016[ 29 ]; Lan et al, 2017[ 30 ]; Lazo-Gomez and Tapia, 2017[ 31 ]; Li et al, 2018[ 32 ]; Liu and Zhou, 2017[ 34 ]; Liu et al, 2017[ 35 ]; Lu et al, 2018[ 36 ]; Maciel et al, 2016[ 37 ]; Maksymchuk et al, 2017[ 38 ]; Mitani et al, 2017[ 40 ]; Mkhize et al, 2017[ 41 ]; Naseer et al, 2017[ 42 ]; Pandya et al, 2017[ 45 ]; Patrizio et al, 2018[ 46 ]; Qin et al, 2017[ 47 ]; Ren et al, 2018[ 48 ]; Sameni et al, 2018[ 49 ]; Singh et al, 2018[ 51 ]; Sohn et al, 2018[ 52 ]; Tinay et al, 2017[ 53 ]; Veith et al, 2017[ 54 ]; Wu et al, 2018[ 55 ]; Xingyu et al, 2016[ 56 ]; Yang et al, 2017[ 57 ]; Yang et al, 2018[ 58 ]; Yarahmadi et al, 2017[ 60 ]; Yarahmadi et al, 2018[ 59 ]; Yazıcı et al, 2018[ 61 ]; Yuan et al, 2016[ 63 ]; Yuan et al, 2018[ 62 ]; Zhang et...…”

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confidence: 99%