Protective effects of resveratrol against cisplatin-induced testicular and epididymal toxicity in rats

Reddy, K. Pratap; Madhu, P.; Reddy, P. Sreenivasula

doi:10.1016/j.fct.2016.02.017

Cited by 80 publications

(65 citation statements)

References 55 publications

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“…Complementary and alternative medicine may have a unique role in treating CDDP‐induced nephrotoxicity and traditional Chinese medicines have been used in China to prevent diseases for thousands of years. Some active natural products including epigallocatechin‐3‐gallate, saikosaponin‐D and resveratrol (Sahin et al , ; Ma et al , ; Reddy et al , ) have been used to treat CDDP‐induced nephrotoxicity. Thus, it is reasonable to develop effective natural products from medicinal plants for the treatment of CDDP‐induced nephrotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of dioscin against cisplatin‐induced nephrotoxicity via the microRNA‐34a/sirtuin 1 signalling pathway

Zhang

Tao

Yin

et al. 2017

British J Pharmacology

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Section: Introductionmentioning

confidence: 99%

Protective effects of dioscin against cisplatin‐induced nephrotoxicity via the microRNA‐34a/sirtuin 1 signalling pathway

Zhang

Tao

Yin

et al. 2017

British J Pharmacology

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“…These results are consistent with those of many previous studies. For example, Reddy et al () showed that CP administration (3 mg/kg) significantly increased the TBARS level and significantly decreased the activity of SOD and CAT in rat testicular tissue. In a study by Aksu et al (), CP (10 mg/kg) administration resulted in a marked increase in malondialdehyde levels; a marked decrease in GPx, CAT and SOD activities; and a marked reduction in GSH levels as compared to these parameters in control rats.…”

Section: Discussionmentioning

confidence: 99%

“…The high polyunsaturated membrane lipid content of the testes makes the testes more susceptible to the effects of oxidative agents such as CP (Gevrek & Erdemir, ). The protective effect of various natural substances, including fish oil (Ciftci et al, ), curcumin (Gevrek & Erdemir, ), resveratrol (Reddy et al, ), hesperidin (Kaya et al, ) and rutin (Aksu et al, ), against CP‐induced reproductive system damage has also been demonstrated in many studies. To our knowledge, the potential beneficial effects of β‐glucans against CP‐induced reproductive toxicity have not been studied previously.…”

Section: Introductionmentioning

confidence: 99%

“…An imbalance between the reactive oxygen species and the antioxidant defence system of a tissue is defined as oxidative stress that cause lipid peroxidation and the inactivation of many enzymes (Bentli, Ciftci, Cetin, & Otlu, ). The suppression of steroidogenesis and the formation of reactive oxygen species are the main mechanisms of CP‐induced reproductive toxicity (Reddy, Madhu, & Reddy, ). The reactive oxygen species damages the cellular components such as lipid, protein, DNA, mitochondria and endoplasmic reticulum.…”

Section: Introductionmentioning

confidence: 99%

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Favourable effect of β‐glucan treatment against cisplatin‐induced reproductive system damage in male rats

et al. 2019

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The aim of this study was to investigate the potential beneficial effects of β‐glucan treatment against oxidative, histological and spermatological damage caused by cisplatin on the male reproductive system. Twenty‐eight Sprague Dawley male rats were used in the study. The rats were randomly divided into four equal‐sized groups: a control group, cisplatin group (7 mg/kg in a single‐dose cisplatin administered intraperitoneally), β‐glucan group (β‐glucan given at a dose of 50 mg kg−1 d−1 for 14 day) and a cisplatin plus β‐glucan group (cisplatin and β‐glucan administered together at the same dose). Cisplatin administration induced an increase in the level of thiobarbituric acid‐reactive substances, a lipid peroxidation indicator. It induced a decrease in enzymatic (superoxide dismutase, catalase and glutathione peroxidase) activities and nonenzymatic (reduced glutathione) antioxidant levels. In addition, cisplatin caused both histological and spermatological damage, as shown by a decrease in sperm motility and epididymal sperm concentrations and an increase in abnormal sperm rates. The β‐glucan treatment improved cisplatin‐induced oxidative, histological and spermatological damage. This study revealed that β‐glucan treatment provided prevention against male reproductive system damage caused by cisplatin. These preventative effects were likely due to its antioxidant properties.

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“…It was shown that RVT protects the Cis induced testis damage in mice by the inhibition of oxidative stress [42]. Furthermore, it was observed that 45 days RVT (20mg/kg body weight) treatment ameliorates oxidant, steroidogenic and spermatogenic activity which was detoriated by the injection of 3 mg/kg Cis for 3 days [43]. Parallel to this study's results, we observed that RVT treatment enhanced antioxidant activity, testis morphology, inhibited apoptosis and inflammation from side effects of a Cis.…”

Section: Discussionmentioning

confidence: 98%

Resveratrol treatment reduces apoptosis and morphological alterations in cisplatin induced testis damage

Nagehan¹,

Şener²,

Ercan³

2019

jrp

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Cisplatin commonly used as a chemotheropotic agent however, it is associated with numerous side effects such as reproductive cytotoxicity. It causes spermatogenic cell death and DNA damage in spermatozoa via the formation of reactive oxygene species. Resveratrol (3,5,4'-trans-trihydroxystilbene), a natural phytoalexin, is a potent antioxidant agent, present in a wide variety of dietary sources including grapes, plums and peanuts. The aim of present study to evaluate the beneficial effects of resveratrol on cisplatin induced testis damage. Male Sprague Dawley rats were used in the study and four experimental groups were formed as: 1-saline applied control, 2-resveratrol applied control, 3-cisplatin and 4-cisplatin+resveratrol groups. Following a single dose of cisplatin (7 mg/kg i.p.), either saline or resveratrol (10 mg/kg, orally) was administered for 5 days. Testis samples were prepared for histopathological and ultrastructural evaluations, cell proliferation and apoptosis. Tissue malondialdehyde (MDA), glutathione (GSH) levels and myeloperoxidase (MPO) activity were determined biochemically. Degenerated and atrophic tubules of tissue, apoptotic cells, MDA level and MPO activity were increased although proliferation index and GSH level were decreased in cisplatin group. Degenerated tight junctions between the Sertoli cells and vacuole formation in germinal epithelial cells were also revealed at this group. However, resveratrol treatment reduced degenerated and atrophic tubules, apoptotic cells, vacuole formation in germinal epithelial cells, MDA level and MPO activity and increased proliferation index and GSH level in testis. These results showed that resveratrol ameliorates cisplatin induced testis injury by the impairment of oxidative stress and apoptosis.

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Protective effects of resveratrol against cisplatin-induced testicular and epididymal toxicity in rats

Cited by 80 publications

References 55 publications

Protective effects of dioscin against cisplatin‐induced nephrotoxicity via the microRNA‐34a/sirtuin 1 signalling pathway

Protective effects of dioscin against cisplatin‐induced nephrotoxicity via the microRNA‐34a/sirtuin 1 signalling pathway

Favourable effect of β‐glucan treatment against cisplatin‐induced reproductive system damage in male rats

Resveratrol treatment reduces apoptosis and morphological alterations in cisplatin induced testis damage

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