Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-&amp;kappa;B signaling pathway

Feng, Jing; Liu, Shuai; Ma, Sai; Zhao, Jian; Zhang, Wei; Wei, Qi; Cao, Peng-chong; Wang, Zheng; Lei, Wei

doi:10.1093/abbs/gmu103

Cited by 85 publications

(91 citation statements)

References 32 publications

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“…Additionally, Feng et al suggested that there is a reverse correlation between BMD and OC levels in osteoporotic rat models, i.e., BMD values decreased in parallel with increased OC serum levels [48]. These results show that the levels of osteocalcin show the direct synthesis and activity of osteoblasts.…”

Section: Discussionmentioning

confidence: 92%

Effects of Administration of Amlodipine and Lacidipine on Inflammation-Induced Bone Loss in the Ovariectomized Rat

et al. 2015

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This study was performed to evaluate the possible protective effect of two calcium channel blocker's "lacidipine (LAC) and amlodipine (AML)" on bone metabolism in an experimental ovariectomized and inflammation-induced osteoporosis rat model (OVXinf). For the purpose of this study, the rats were divided into eight groups, each containing eight rats: sham-operated control (group 1, SH), sham + inflammation (group 2, SHinf), ovariectomy (group 3, OVX), ovariectomy + inflammation (group 4, OVXinf), ovariectomy + LAC 4 mg/kg (group 5, OVX + LAC), ovariectomy + inflammation + LAC 4 mg/kg (group 6, OVXinf + LAC), ovariectomy + AML 5 mg/kg (group 7, OVX + AML), ovariectomy + inflammation + AML 5 mg/kg (group 8, OVXinf + AML). The levels of osteocalcin and osteopontin decreased in OVXinf + LAC and OVXinf + AML groups. The serum levels of TNF-α, IL-1β, and IL-6 were increased significantly in the OVXinf rats compared with the SH group. Gene expression levels of the osteogenic factor runt-related transcription factor 2 (Runx2) and type I collagen 1A1 (Col1A1) significantly decreased in the OVXinf group, when compared with the control group. AML or LAC administrations increased the levels of Runx2 and Col1A1. These results suggest that amlodipine and lacidipine may be a novel therapeutic target for radical osteoporosis treatment in hypertensive patients.

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Section: Discussionmentioning

confidence: 92%

Effects of Administration of Amlodipine and Lacidipine on Inflammation-Induced Bone Loss in the Ovariectomized Rat

et al. 2015

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“…The role of another cysteine protease inhibitor, CST3, was reported to reduce the formation of osteoclasts by interfering with the late differentiation of osteoclast precursors . Studies have shown that inhibition of the NF‐κB pathway could relieve OP . Moreover, cystatin was demonstrated to affect the NF‐κB pathway .…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, the rate of bone resorption exceeds the rate of bone formation of osteoclasts largely contributes to OP in postmenopausal women . The NF‐κB pathway could mediate osteoblast differentiation, and inhibition of the NF‐κB pathway promoted osteoblast differentiation and suppressed osteoclastogenesis . In the present study, we investigated the effect of CST5 on the activation and bone resorption of osteoclasts through regulation of the NF‐κB pathway, thus affecting the progression of OP.…”

Section: Discussionmentioning

confidence: 96%

“…21 Studies have shown that inhibition of the NF-κB pathway could relieve OP. 22,23 Moreover, cystatin was demonstrated to affect the NF-κB pathway. 16 Combined with DEG screening results, we put forward a hypothesis that CST5 could mediate the NF-κB pathway, thus affecting osteoclasts function and finally affecting OP.…”

Section: Cst5 Is Speculated To Affect Op Through Mediation Of the Nmentioning

confidence: 99%

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Up‐regulated CST5 inhibits bone resorption and activation of osteoclasts in rat models of osteoporosis via suppression of the NF‐κB pathway

Wang

Zhang

et al. 2019

J Cellular Molecular Medi

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Here, we aim at exploring the effect of CST5 on bone resorption and activation of osteoclasts in osteoporosis (OP) rats through the NF‐κB pathway. Microarray analysis was used to screen the OP‐related differentially expressed genes. Osteoporosis was induced in rats by intragastric retinoic acid administration. The serum levels of tartrate‐resistant acid phosphatase (TRAP), bone alkaline phosphatase (BALP) and osteocalcin (OC) and the expression of CD61 on the surface of osteoclasts were examined. The number of osteoclasts and the number and area of resorption pits were detected. Besides, the pathological changes and bone mineral density in bone tissues of rats were assessed. Also, the relationship between CST5 and the NF‐κB pathway was identified through determining the expression of CST5, RANKL, RANK, OPG, p65 and IKB. Poorly expressed CST5 was indicated to affect the OP. CST5 elevation and inhibition of the NF‐κB pathway decreased serum levels of TRAP, BALP and OC and expression of CD61 in vivo and in vitro. In OP rats, CST5 overexpression increased trabecular bones and bone mineral density of bone tissues, but decreased trabecular separation, fat within the bone marrow cavities and the number of osteoclasts through inhibiting the NF‐κB pathway. In vivo experiments showed that CST5 elevation inhibited growth in number and area of osteoclastic resorption pits and restrained osteoclastic bone absorption by inhibiting the NF‐κB pathway. In summary, overexpression of CST5 suppresses the activation and bone resorption of osteoclasts by inhibiting the activation of the NF‐κB pathway.

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“…Recently, a study by Feng et al tested the ability of resveratrol, a plant polyphenol acting as an agonist of Sirt1, to promote osteogenesis in vitro and prevent bone loss in animal models and, thus, its possible protective effect on osteoporosis [28]. In rats with bilateral ovariectomy, resveratrol moderately restored the serum level of ALP and OCN and improved bone structure.…”

Section: Post-translational Histone Modifications In Bone Biologymentioning

confidence: 99%

Epigenetic Mechanisms in Bone Biology and Osteoporosis: Can They Drive Therapeutic Choices?

Marini

Cianferotti

Brandi

2016

IJMS

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Osteoporosis is a complex multifactorial disorder of the skeleton. Genetic factors are important in determining peak bone mass and structure, as well as the predisposition to bone deterioration and fragility fractures. Nonetheless, genetic factors alone are not sufficient to explain osteoporosis development and fragility fracture occurrence. Indeed, epigenetic factors, representing a link between individual genetic aspects and environmental influences, are also strongly suspected to be involved in bone biology and osteoporosis. Recently, alterations in epigenetic mechanisms and their activity have been associated with aging. Also, bone metabolism has been demonstrated to be under the control of epigenetic mechanisms. Runt-related transcription factor 2 (RUNX2), the master transcription factor of osteoblast differentiation, has been shown to be regulated by histone deacetylases and microRNAs (miRNAs). Some miRNAs were also proven to have key roles in the regulation of Wnt signalling in osteoblastogenesis, and to be important for the positive or negative regulation of both osteoblast and osteoclast differentiation. Exogenous and environmental stimuli, influencing the functionality of epigenetic mechanisms involved in the regulation of bone metabolism, may contribute to the development of osteoporosis and other bone disorders, in synergy with genetic determinants. The progressive understanding of roles of epigenetic mechanisms in normal bone metabolism and in multifactorial bone disorders will be very helpful for a better comprehension of disease pathogenesis and translation of this information into clinical practice. A deep understanding of these mechanisms could help in the future tailoring of proper individual treatments, according to precision medicine’s principles.

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Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-κB signaling pathway

Cited by 85 publications

References 32 publications

Effects of Administration of Amlodipine and Lacidipine on Inflammation-Induced Bone Loss in the Ovariectomized Rat

Effects of Administration of Amlodipine and Lacidipine on Inflammation-Induced Bone Loss in the Ovariectomized Rat

Up‐regulated CST5 inhibits bone resorption and activation of osteoclasts in rat models of osteoporosis via suppression of the NF‐κB pathway

Epigenetic Mechanisms in Bone Biology and Osteoporosis: Can They Drive Therapeutic Choices?

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