Protective effects of resveratrol on hydrogen peroxide-induced apoptosis in rat pheochromocytoma (PC12) cells

Jang, Jung‐Hee; Surh, Young‐Joon

doi:10.1016/s1383-5718(01)00233-9

Cited by 201 publications

(104 citation statements)

References 51 publications

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“…Many authors have reported a protective role of lower dose RSV against certain cellular insults, including oxidative stress-induced apoptosis by ethanol and hydrogen peroxide, as well as drug-induced apoptosis in cancer cells. [13][14][15] In particular, RSV has been shown to be antagonistic to paclitaxel-induced apoptosis in breast cancer and neuroblastoma cells at lower doses between 1-100 μM. 16 These findings are concordant with our results, which demonstrated that lower dose RSV protected against 5-FU-evoked apoptosis in colon cancer cells.…”

Section: Discussionsupporting

confidence: 90%

Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: The roles of caspase-6 and p53

Chan

Phoo²,

Clément³

et al. 2008

Cancer Biology & Therapy

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Section: Discussionsupporting

confidence: 90%

Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: The roles of caspase-6 and p53

Chan

Phoo²,

Clément³

et al. 2008

Cancer Biology & Therapy

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“…Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a stilbenoid, a type of natural polyphenol compound, and a phytoalexin produced naturally by several plants especially the roots of the Japanese Knotweed when challenged from bacterial or fungal attack. Diverse effects of resveratrol as cardioprotective, anticarcinogenic, immunomodulatory, antioxidant, and antiapoptotic agent have been reported previously [12,17,33]. One of the most robust and reproducible effects of resveratrol is to increase the mitochondrial mass [3,22].…”

Section: Discussionmentioning

confidence: 99%

Resveratrol treatment during goat oocytes maturation enhances developmental competence of parthenogenetic and hand-made cloned blastocysts by modulating intracellular glutathione level and embryonic gene expression

Mukherjee

Malik

Saha

et al. 2013

J Assist Reprod Genet

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Purpose The aim of the present study was to determine whether supplementation of resveratrol, a stilbenoid antioxidant with therapeutic significance, influences goat (Capra hircus) oocyte maturation and subsequent embryonic development and expression of apoptosis and early embryonic development-related genes. Methods Five different concentrations of resveratrol (0.1, 0.25, 0.5, 2.0 and 5.0 μM) were used in in vitro maturation (IVM) medium. Cell tracker blue and 2′,7′-dichlorodihydrofluorescein diacetate (H 2 DCFDA) fluorescent stains were used to assay intracellular glutathione and reactive oxygen species levels in mature oocytes. Parthenogenetic activation and hand-made cloning were performed to check the developmental potential following resveratrol treatment. We used quantitative real-time PCR to analyze embryonic gene expression. Result Compared to control, no significant improvement was observed in nuclear maturation in resveratrol-treated groups and at 5.0 μM concentration maturation rate decreased significantly (P <0.05). But resveratrol treatment at the concentrations of 0.25, 0.5 μM significantly reduced intracellular ROS, and increased GSH concentrations. Oocytes treated with 0.25, 0.5 μM resveratrol when subsequently used for PA and HMC, higher extent of blastocyst yields were observed. Expression analysis of proapoptotic (Bax) gene in mature oocytes, cumulus cells, and HMC-derived blastocysts revealed lesser transcript abundances in various resveratrol-treated groups., however no change in the same was observed for antiapoptotic gene (Bcl2). Differential expression of genes associated with developmental competence and nuclear reprogramming was also observed in HMC-derived blastocysts. Conclusion Our results show that resveratrol treatment at optimum concentrations (0.25 and 0.5 μM) during IVM produced beneficial microenvironment within oocytes by increasing the intracellular GSH, decreasing ROS level and this in turn, stimulated embryonic development and regulated gene expression.

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“…These studies substantiated in vivo preclinical efficacy of resveratrol and suggest that resveratrol can be considered as a candidate drug for cancer therapy. However, one recent study suggests that resveratrol can prevent hydrogen peroxide-induced apoptosis in rat pheochromocytoma cells (46). A lower concentration of resveratrol is also reported to inhibit caspase activation and release of cytochrome c induced by H 2 O 2 (47).…”

Section: Discussionmentioning

confidence: 99%

Caspase-2 Triggers Bax-Bak-dependent and -independent Cell Death in Colon Cancer Cells Treated with Resveratrol

Morser

Gandhi

Bhavya

et al. 2006

Journal of Biological Chemistry

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Polyphenol phytoalexin (resveratrol), found in grapes and red wine is a strong chemopreventive agent with promising safety records with human consumption and unique forms of cell death induction in a variety of tumor cells. However, the mechanism of resveratrol-induced apoptosis upstream of mitochondria is still not defined. The results from this study suggest that caspase-2 activation occurs upstream of mitochondria in resveratrol-treated cells.

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Protective effects of resveratrol on hydrogen peroxide-induced apoptosis in rat pheochromocytoma (PC12) cells

Cited by 201 publications

References 51 publications

Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: The roles of caspase-6 and p53

Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: The roles of caspase-6 and p53

Resveratrol treatment during goat oocytes maturation enhances developmental competence of parthenogenetic and hand-made cloned blastocysts by modulating intracellular glutathione level and embryonic gene expression

Caspase-2 Triggers Bax-Bak-dependent and -independent Cell Death in Colon Cancer Cells Treated with Resveratrol

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