Protective Effects of Saizen in Combination With Stilamin on Intestinal Mucosa of a Rabbit Model of Severe Acute Pancreatitis

Lü, Yan; Yu, Yiming; Yang, Meilan; Liu, Hui; Li, Bin; Xu, Hongwei

doi:10.1097/mpa.0b013e3182554d8e

Cited by 4 publications

(3 citation statements)

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“…According to the current literature, neuropeptide receptors and the potential clinical relevance of the ligand SST 28 Neurogenic inflammation in rats, inhibits proliferation, chemotaxis, cytokine and immunoglobulin secretion of lymphocytes, monocytes and macrophages, murine EAE, rabbit acute pancreatitis [127,[132][133][134][135]147] sst2 sst3 sst5…”

Section: Discussionmentioning

confidence: 99%

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Neuropeptide receptors as potential drug targets in the treatment of inflammatory conditions

Pintér

Pozsgai

Hajna

et al. 2013

Brit J Clinical Pharma

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Cross-talk between the nervous, endocrine and immune systems exists via regulator molecules, such as neuropeptides, hormones and cytokines. A number of neuropeptides have been implicated in the genesis of inflammation, such as tachykinins and calcitonin gene-related peptide. Development of their receptor antagonists could be a promising approach to anti-inflammatory pharmacotherapy. Anti-inflammatory neuropeptides, such as vasoactive intestinal peptide, pituitary adenylate cyclase-activating polypeptide, a-melanocyte-stimulating hormone, urocortin, adrenomedullin, somatostatin, cortistatin, ghrelin, galanin and opioid peptides, are also released and act on their own receptors on the neurons as well as on different inflammatory and immune cells. The aim of the present review is to summarize the most prominent data of preclinical animal studies concerning the main pharmacological effects of ligands acting on the neuropeptide receptors. Promising therapeutic impacts of these compounds as potential candidates for the development of novel types of anti-inflammatory drugs are also discussed.

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Section: Discussionmentioning

confidence: 99%

“…Octreotide was shown to inhibit cerulein‐induced acute murine pancreatitis. Somatostatin was also reported to relieve rabbit pancreatitis in combination with growth hormone .…”

Section: Anti‐inflammatory Neuropeptidesmentioning

confidence: 99%

Neuropeptide receptors as potential drug targets in the treatment of inflammatory conditions

Pintér

Pozsgai

Hajna

et al. 2013

Brit J Clinical Pharma

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“…There is overwhelming evidence that SAP is combined with different degree of multiple organ dysfunction syndrome. 22 , 23 Moreover, some clinical and experimental studies 24 , 25 have shown that intestinal mucosa injury is a critical part in the progression of SAP. Consistently, in this study, we find that the villous height, crypt depth and mucosal thickness of small intestine tissue in SAP group gradually decrease along with the disease progression.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-22 Attenuates Acute Pancreatitis-Associated Intestinal Mucosa Injury in Mice via STAT3 Activation

Bai

Yang³

2021

Gut and Liver

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Background/Aims: is an important cytokine maintaining homeostasis at barrier surfaces. In this study, the role of IL-22 in acute pancreatitis-associated intestinal injury was further explored.Methods: Severe acute pancreatitis (SAP) was induced by administration of L-arginine in Balb/c mice at different time gradients. Histopathological examinations were made in both the pancreas and small intestine. Furthermore, recombinant murine was administrated to L-arginine-induced SAP mice by intraperitoneal injection. The mRNA levels of IL-22R1, Reg-IIIβ, Reg-IIIγ, Bcl-2, and Bcl-xL were detected in the small intestine by real-time polymerase chain reaction, and protein levels of total and phosphorylated STAT3 were assessed via Western blot.Results: Compared with normal control group, 72 hours of L-arginine exposure induced the most characteristic histopathological changes of SAP, evidenced by pathological changes and serum amylase levels. Meanwhile, significant pancreatitis-associated intestinal mucosa injury was also observed. The gene expression levels of antimicrobial proteins Reg-IIIβ, Reg-IIIγ and anti-apoptosis proteins Bcl-2, Bcl-xL were downregulated in small intestine. Furthermore, Larginine-induced SAP was attenuated by rIL-22 treatment. Importantly, pancreatitis-associated intestinal mucosa injury was also ameliorated, reflected by improved pathological changes and significant increase in gene expression levels of Reg-IIIβ, Reg-IIIγ, Bcl-2 and Bcl-xL. Consistently, serum amylase levels and mortality were decreased in mice treated with rIL-22. Mechanistically, the upregulated expressions of these protective genes were achieved by activating STAT3.Conclusions: Exogenous rIL-22 attenuates L-arginine-induced acute pancreatitis and intestinal mucosa injury in mice, via activating STAT3 signaling pathway and enhancing the expression of antimicrobial peptides and antiapoptotic genes.

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WITHDRAWN: Stilamin inhibits intestinal and pancreatic injury in rats with severe acute pancreatitis by down-regulating LCN2 expression

Ren

Cui

et al. 2018

Pancreatology

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Protective Effects of Saizen in Combination With Stilamin on Intestinal Mucosa of a Rabbit Model of Severe Acute Pancreatitis

Abstract: The combination of saizen with stilamin can enhance intestinal mucosa barrier function.

Cited by 4 publications

References 20 publications

Neuropeptide receptors as potential drug targets in the treatment of inflammatory conditions

Neuropeptide receptors as potential drug targets in the treatment of inflammatory conditions

Interleukin-22 Attenuates Acute Pancreatitis-Associated Intestinal Mucosa Injury in Mice via STAT3 Activation

WITHDRAWN: Stilamin inhibits intestinal and pancreatic injury in rats with severe acute pancreatitis by down-regulating LCN2 expression

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