Protective effects of Salvianic acid A against multiple-organ ischemia-reperfusion injury: a review

Abstract

Ischemia-reperfusion (I/R) injury refers to a new injury caused by reperfusion after the restoration of ischemic tissue or organ blood supply. Salvianic acid A (danshensu) is a primary active ingredient extracted from Salvia miltiorrhiza. It has a protective function against I/R injury in the cardiovascular system, brain, liver, kidney, gastrointestinal tract, and other organs. This article reviews evidence of the protective effects of Salvianic acid A and its potential mechanisms of action in organ I/R injury protection. The aim of this review is to investigate the role of Salvianic acid A in the treatment of I/R injury, providing a reference resource that could facilitate subsequent studies.

Nanocarriers Loaded with Danshensu for Treating Ischemic Stroke by Reducing Oxidative Stress and Glial Overactivation

“…Therefore, nanodelivery technology must be chosen to effectively target and deliver DSS to the brain. Importantly, our group has previously demonstrated that DSS treatment inhibits oxidative stress, suppresses inflammatory reactions, and decreases neuronal apoptosis in rats, suggesting its potential as a human stroke treatment candidate. , …”

“…Importantly, our group has previously demonstrated that DSS treatment inhibits oxidative stress, suppresses inflammatory reactions, and decreases neuronal apoptosis in rats, suggesting its potential as a human stroke treatment candidate. 20,21 In this study, we prepared a three-dimensional (3D) thioketal cross-linked chitosan with carboxyl groups and carboxymethyl β-cyclodextrin network to enhance the efficiency of loading DSS and control its release into injured cerebral regions. This 3D network was first chemically synthesized by linking CS with ketal; subsequently, carboxymethyl β-cyclodextrin were added to form the network.…”