Protective effects of sinomenine hydrochloride on lead-induced oxidative stress, inflammation, and apoptosis in mouse liver

Liu, Ying; Cai, Wenjie; Ai, Zichun; Xue, Chenyu; Cao, Rujing; Dong, Na

doi:10.1007/s11356-022-22386-1

Cited by 10 publications

(8 citation statements)

References 39 publications

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“…Liver damage is quite common due to the chronic toxicity of Pb [27]. 2023) also found an increase in the levels of in ammatory response indicators, TNF-α, IL-1β, and IL-6, in liver tissue after Pb exposure, and noted that this increase was reversed by sinomenine hydrochloride [27]. In our study, the increased levels of TNF-α, IL-1β, and IL-6, induced by CBD, were reversed.…”

Section: Discussionsupporting

confidence: 72%

“…The liver is highly exposed to xenobiotic-induced injury due to its signi cant involvement in xenobiotic metabolism. Liver damage is quite common due to the chronic toxicity of Pb [27]. 2023) also found an increase in the levels of in ammatory response indicators, TNF-α, IL-1β, and IL-6, in liver tissue after Pb exposure, and noted that this increase was reversed by sinomenine hydrochloride [27].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the protective effect of cannabidiol in lead toxicity in mice

Şahin,

Müderrisoğlu,

Mortaş

et al. 2024

Preprint

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Purpose Considering the significant toxicity caused lead (Pb), identifying substances that can prevent or alleviate the toxic effects of Pb is important. This study aims to evaluate the protective effects of an anti-inflammatory, antioxidant substance; cannabidiol (CBD) against Pb toxicity. Methods A total of 4 groups, each consisting 10 mice were used. Groups I and III were not exposed to Pb, while Pb exposure was induced in groups II and IV by adding 1 gr/L of Pb to the drinking water. CBD was administered daily via intragastric gavage at a 25 mg/kg dose in groups III and IV. At the end of 30 days, the mice were euthanized, and blood and liver, kidney, testis tissue samples were collected. Levels of oxidative stress markers GSH, CAT, MPO, and pro-inflammatory cytokines TNF-α, IL-1β, IL-6 were measured using ELISA kits. Histological evaluation of the tissues samples was performed. Results Comparison between groups II and IV showed that CBD alleviated the oxidant and inflammatory damage caused by Pb as blood CAT, GSH levels increased and MPO, TNF- α, IL-1β, IL-6 levels decreased in CBD administered, Pb intoxicated mice compared to only Pb intoxicated mice. CBD also decreased the toxic effects of Pb in liver, kidney and testis tissues (p < 0.0001 for most comparisons). Comparison between groups III and IV revealed similar results as it showed that Pb reduced the beneficial effects of CBD. Conclusion This study showed that CBD has a protective effect against Pb toxicity. This finding indicates that CBD could be used as a food additive or supportive treatment for alleviating the toxic effects of Pb at risked population groups.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Evaluation of the protective effect of cannabidiol in lead toxicity in mice

Şahin,

Müderrisoğlu,

Mortaş

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…Accordingly, Researchers have shown significant potentials of SN in the positive augmentation of immunohistochemically (increasing Bax and decreasing Bcl-2) proteins, regulatory of oxidative stress and inflammation, which were considered as molecular mechanisms behind SN efficacy in the inhibition of growth and migration of retinoblastoma cells in an in vitro experiment [ 56 ]. Similarly, in vitro and in vivo studies have correlated the ameliorative effect of sinomenine on cardiac hypertrophy with its positive regulation of immunohistochemically (Bax/Bcl-2) proteins [ 27 , 57 ].…”

Section: Discussionmentioning

confidence: 99%

“…and thus faster wound-healing actions. Similarly, numerous studies have shown the inhibitory potentials of SN in different animal models exposed to different oxidative stress conditions [ 27 , 57 , 61 ].…”

Section: Discussionmentioning

confidence: 99%

Sinomenine accelerate wound healing in rats by augmentation of antioxidant, anti-inflammatory, immunuhistochemical pathways

Jabbar,

Abdul-Aziz Ahmed,

Abdulla

et al. 2024

Heliyon

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“…SH downregulated Caspase-3, Bax, IL-1β, TNF-α, NF-κB, NF-κB p65, and IκBα and upregulated BcL-2 in Pb-exposed mice. The mechanism suggested that SH enhanced anti-inflammatory properties by reducing oxidative stress and inhibiting the NF-κB signaling pathway, thus alleviating chronic Pb poisoning [ 209 ].…”

Section: Organs Protectionmentioning

confidence: 99%

Bioactivities and Mechanisms of Action of Sinomenine and Its Derivatives: A Comprehensive Review

Hou,

Huang,

Huang

et al. 2024

Molecules

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Sinomenine, an isoquinoline alkaloid extracted from the roots and stems of Sinomenium acutum, has been extensively studied for its derivatives as bioactive agents. This review concentrates on the research advancements in the biological activities and action mechanisms of sinomenine-related compounds until November 2023. The findings indicate a broad spectrum of pharmacological effects, including antitumor, anti-inflammation, neuroprotection, and immunosuppressive properties. These compounds are notably effective against breast, lung, liver, and prostate cancers, exhibiting IC50 values of approximately 121.4 nM against PC-3 and DU-145 cells, primarily through the PI3K/Akt/mTOR, NF-κB, MAPK, and JAK/STAT signaling pathways. Additionally, they manifest anti-inflammatory and analgesic effects predominantly via the NF-κB, MAPK, and Nrf2 signaling pathways. Utilized in treating rheumatic arthritis, these alkaloids also play a significant role in cardiovascular and cerebrovascular protection, as well as organ protection through the NF-κB, Nrf2, MAPK, and PI3K/Akt/mTOR signaling pathways. This review concludes with perspectives and insights on this topic, highlighting the potential of sinomenine-related compounds in clinical applications and the development of medications derived from natural products.

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Protective effects of sinomenine hydrochloride on lead-induced oxidative stress, inflammation, and apoptosis in mouse liver

Cited by 10 publications

References 39 publications

Evaluation of the protective effect of cannabidiol in lead toxicity in mice

Evaluation of the protective effect of cannabidiol in lead toxicity in mice

Sinomenine accelerate wound healing in rats by augmentation of antioxidant, anti-inflammatory, immunuhistochemical pathways

Bioactivities and Mechanisms of Action of Sinomenine and Its Derivatives: A Comprehensive Review

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