Protective effects of St. John’s wort in the hepatic ischemia/reperfusion injury in rats

Atalay, Süleyman; Soylu, Belkıs; Aykaç, Aslı; Öğünç, Ayliz Velioğlu; Çetınel, Şule; Özkan, Naziye; Erzik, Can; Şehirli, Ahmet Özer

doi:10.5152/turkjsurg.2018.3952

Cited by 12 publications

(10 citation statements)

References 26 publications

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“…Studies have shown a reduction in Na + -K + -ATPase level after hepatic ischemia reperfusion (32,33). Our study revealed that Na + -K + -ATPase activity in the liver tissue was lower in the IR group when compared to the control group.…”

Section: A B C Dsupporting

confidence: 41%

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Protective effects of spironolactone against hepatic ischemia/reperfusion injury in rats

et al. 2019

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Objective: In the present study, it was aimed to study the antioxidant effects of spironolactone (SPL) to determine its possible protective effects in hepatic ischemia reperfusion injury. Material and Methods: Hepatic artery, portal vein, and bile duct of Wistar albino rats were clamped for 45 minutes under anesthesia to form an ischemia period. Then reperfusion was allowed and the rats were decapitated 60 minutes later. SPL (20 mg/kg, p.o.) or SF was orally administered for 30 minutes before ischemia. Rats in the control arm underwent sham surgery and were administered isotonic saline. Liver function was studied by measuring aspartate aminotransferase (AST), alanine aminotransferase (ALT), tumor necrosis factor-alpha (TNF-α), and interleukin 1beta (IL-1β) levels. Malondialdehyde (MDA), glutathione (GSH), luminol, and lucigenin levels, myeloperoxidase (MPO) and Na +-K +-ATPase enzyme activities were analyzed to study tissue injury under light microscope. Results: While IR increased AST, ALT, TNF-α, and IL-1β levels and MDA, luminol, and lusigenin levels and MPO activities, it caused a decrease in GSH levels and Na + K +-ATPase activity. Spironolactone administration significantly improved these values. Conclusion: Protective effects of SPL against ischemia/reperfusion injury via various mechanisms suggest that this agent may become a novel treatment agent in clinical practice.

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Section: A B C Dsupporting

confidence: 41%

“…Luminol hydroxyl radical is an indicator of the formation of reactive oxygen metabolites such as hydrogen peroxide and hypochloric acid. Lusigenin marks the formation of superoxide anion radical (33). They indirectly indicate the level of ROM-mediated tissue injury.…”

Section: A B C Dmentioning

confidence: 99%

Protective effects of spironolactone against hepatic ischemia/reperfusion injury in rats

et al. 2019

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“…In the present study hepatic IRI resulted in a significant elevation in MPO content. These results go in harmony with many of previous studies either directly (46) or remotely (47) which could be attributed to the induced expression of NF-κB and/or IL-1β that accomplished in the present work. The pretreatment with CEL could provide a significant cut down in the renal MPO content.…”

Section: Beta-actin Hsf-1 B Hsf-1 Hsp90 a Hsp90supporting

confidence: 93%

The reno-protective effect of celastrol mediated by Nrf2/HO-1 activation and NF-κB/NLRP3 suppression in hepatic ischemia/reperfusion model

Ibrahim

Mohamed²,

Ellah³

et al. 2022

Azhar International Journal of Pharmaceutical and Medical Scien

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“…Sodium/potassium adenosine triphosphatase enzyme takes part in the structure and physiology of liver cells by providing sodium and potassium balance in all cell membranes (45). According to studies, it has been observed that BDL reduces the levels of Na + /K + -ATPase in liver tissue (46,47).…”

Section: Discussionmentioning

confidence: 99%

Dodder (Cuscuta sp.) Extract Ameliorates Liver Fibrosis in Bile Duct-Ligated Rats

Albayrak¹,

Özbeyli²,

Şen³

et al. 2022

ejb

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Objective:The aim is to examine the possible protective effect of Cuscuta sp. extract against liver damage induced by biliary obstruction in rats. Materials and Methods:To induce biliary obstruction, the bile duct ligation (BDL) method was used. Sprague Dawley rats were allocated to 4 groups: Control (C), Cuscuta (CUS), bile duct ligation (BDL), and bile duct ligation + Cuscuta (BDL+CUS). Control and BDL rats were given physiological saline (SF), while CUS and BDL+CUS groups were administered 250 mg/ kg of Cuscuta extract by oral gavage. At the end of 28 th day, the rats were decapitated, serum and tissue samples were collected, and aspartate aminotransferase (AST), alanine transaminase (ALT), and direct and total bilirubin (DB and TB) levels were determined in blood samples. In liver tissues, transforming growth factor-β (TGF-β), 8-hydroxyguanosine (8-OHdG), hydroxyproline, and sodium-potassium ATPase (Na + /K + -ATPase) levels were determined.Results: Serum samples of rats with cholestasis had high ALT, AST, DB, and TB levels, while TGF-β, 8-OHdG, and hydroxyproline concentrations were found to be significantly high in tissues. Hepatic Na + /K + -ATPase levels were decreased through biliary obstruction. Biochemical parameters were drastically reversed by Cuscuta care; also, this was supported histologically. Conclusion:Results showed that Cuscuta extract, through its antioxidant and anti-inflammatory properties, provided protection against oxidative injury by biliary obstruction. Also, these results confirm the traditional use of Cuscuta sp. as hepatoprotective.

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Protective effects of St. John’s wort in the hepatic ischemia/reperfusion injury in rats

Abstract: The obtained results indicate protective effects of St. John's wort on the ischemia/reperfusion injury through various mechanisms, and we are able to suggest that St. John's wort can clinically create a new therapeutic principle.

Cited by 12 publications

References 26 publications

Protective effects of spironolactone against hepatic ischemia/reperfusion injury in rats

Protective effects of spironolactone against hepatic ischemia/reperfusion injury in rats

The reno-protective effect of celastrol mediated by Nrf2/HO-1 activation and NF-κB/NLRP3 suppression in hepatic ischemia/reperfusion model

Dodder (Cuscuta sp.) Extract Ameliorates Liver Fibrosis in Bile Duct-Ligated Rats

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