Protective effects of tea, red wine and cocoa in diabetes. Evidences from human studies

Martín, Maria Ángeles; Goya, Luis; Ramos, Sonia

doi:10.1016/j.fct.2017.09.015

Cited by 61 publications

(32 citation statements)

References 125 publications

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“…In humans and animal models, flavanols or flavanols-rich foods (mainly, cocoa or tea derivates) have demonstrated the ability to reduce body weight, decrease waist circumference and fat percentages, improve glucose metabolism in individuals with type 2 diabetes, obesity or MetS and increase energy expenditure [ 75 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 ]. One of the most described molecular mechanism underlying theses effects are the activation of the AMPK enzyme [ 140 ].…”

Section: Flavanolsmentioning

confidence: 99%

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

et al. 2020

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The prevention and treatment of obesity is primary based on the follow-up of a healthy lifestyle, which includes a healthy diet with an important presence of bioactive compounds such as polyphenols. For many years, the health benefits of polyphenols have been attributed to their anti-oxidant capacity as free radical scavengers. More recently it has been described that polyphenols activate other cell-signaling pathways that are not related to ROS production but rather involved in metabolic regulation. In this review, we have summarized the current knowledge in this field by focusing on the metabolic effects of flavonoids. Flavonoids are widely distributed in the plant kingdom where they are used for growing and defensing. They are structurally characterized by two benzene rings and a heterocyclic pyrone ring and based on the oxidation and saturation status of the heterocyclic ring flavonoids are grouped in seven different subclasses. The present work is focused on describing the molecular mechanisms underlying the metabolic impact of flavonoids in obesity and obesity-related diseases. We described the effects of each group of flavonoids in liver, white and brown adipose tissue and central nervous system and the metabolic and signaling pathways involved on them.

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Section: Flavanolsmentioning

confidence: 99%

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

et al. 2020

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“…In this regard, growing evidence suggests the anti-diabetic activity of cocoa by contributing to control glucose levels (Cordero-Herrera, I. et al, 2015, Costa, C. et al, 2017, Grassi, D. et al, 2008, Jalil, A.-M.-M. et al, 2008, Martín, M.A. et al, 2016, Martín, M.A. et al, 2017, Ruzaidi, A. et al, 2005.…”

Section: Discussionmentioning

confidence: 99%

“…et al, 2006), and have shown beneficial effects against diabetes in humans (Costa, C. et al, 2017, Grassi, D. et al, 2008, Kim, Y. et al, 2016, Martín, M.A. et al, 2016, Martín, M.A. et al, 2017.…”

Section: Introductionmentioning

confidence: 99%

Cocoa intake attenuates renal injury in Zucker Diabetic fatty rats by improving glucose homeostasis

Álvarez-Cilleros

López-Oliva

Goya

et al. 2019

Food and Chemical Toxicology

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Glucotoxicity (high levels of glucose) is a major factor in the pathogenesis of diabetic kidney disease. Cocoa has anti-diabetic effects by lowering glucose levels. However, whether cocoa exerts beneficial effects on the renal cortex glucose homeostasis and the molecular mechanisms responsible for this possible protective activity remain largely unknown. Thus, the potential anti-diabetic properties of cocoa on insulin signalling, glucose transporters and gluconeogenic enzymes were evaluated in the renal cortex of Zucker Diabetic fatty (ZDF) rats. Male ZDF rats were fed a control or cocoa-rich diet (10%), and Zucker Lean animals received the control diet. ZDF rats supplemented with cocoa (ZDF-Co) showed decreased body weight gain, glucose and insulin levels, improved glucose tolerance, insulin resistance and structural alterations in renal cortex. Moreover, cocoa-rich diet ameliorated insulin resistance by reverting decreased tyrosine-phosphorylated-insulin receptor levels and by preventing the inactivation of glycogen synthase kinase-3/glycogen synthase pathway (GSK-3/GS) in the renal cortex of ZDF-Co rats. Cocoa antihyperglycaemic effect also appeared to be mediated through the diminution of phosphoenolpyruvate-carboxykinase (PEPCK), glucose-6phosphatase (G-6-Pase), sodium-glucose-co-transporter-2 (SGLT-2), and glucosetransporter-2 (GLUT-2) levels in ZDF-Co rat´s renal cortex. These findings demonstrate that cocoa alleviates renal injury by contributing to maintain the glucose homeostasis in type 2 diabetic ZDF rats.

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“…Consumption of flavanol-rich dark chocolate (102) and supplementation with epicatechin (103) improve insulin sensitivity in healthy subjects. Importantly, numerous epidemiological studies and RCT have demonstrated that consumption of green tea, red wine and cocoa lowers the risk of type 2 diabetes (108) . In addition, higher consumption of anthocyanins and anthocyanin-rich fruit has also been associated with lower risk of type 2 diabetes (104) .…”

Section: Human Intervention Studiesmentioning

confidence: 99%

Polyphenols in human nutrition: from thein vitroantioxidant capacity to the beneficial effects on cardiometabolic health and related inter-individual variability – an overview and perspective

2019

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Oxidative damage of cells and tissues is broadly implicated in human pathophysiology, including cardiometabolic diseases. Polyphenols, as important constituents of the human diet and potent in vitro free radical scavengers, have been extensively studied for their beneficial effects on cardiometabolic health. However, it has been demonstrated that the in vivo antioxidant activity of polyphenols is distinct from their in vitro free radical-scavenging capacity. Indeed, bioavailability of nutritional polyphenols is low and conditioned by complex mechanisms of absorption, distribution, metabolism and excretion. Nowadays, it is commonly accepted that the cellular antioxidant activity of polyphenols is mainly carried out via modification of transcription of genes involved in antioxidant defence. Importantly, polyphenols also contribute to cardiometabolic health by modulation of a plethora of cellular processes that are not directly associated with antioxidant enzymes, through nutri(epi)genomic mechanisms. Numerous human intervention studies have demonstrated beneficial effects of polyphenols on the key cardiometabolic risk factors. However, inconsistency of the results of some studies led to identification of the inter-individual variability in response to consumption of polyphenols. In perspective, a detailed investigation of the determinants of this inter-individual variability will potentially lead us towards personalised dietary recommendations. The phenomenon of inter-individual variability is also of relevance for supplementation with antioxidant (pro)vitamins.

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Protective effects of tea, red wine and cocoa in diabetes. Evidences from human studies

Cited by 61 publications

References 125 publications

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

Cocoa intake attenuates renal injury in Zucker Diabetic fatty rats by improving glucose homeostasis

Polyphenols in human nutrition: from thein vitroantioxidant capacity to the beneficial effects on cardiometabolic health and related inter-individual variability – an overview and perspective

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