Protective effects of telmisartan on ischemia/reperfusion injury of rat ovary: biochemical and histopathologic evaluation

Kumtepe, Yakup; Odabaşoğlu, Fehmi; Karaca, Mehmet; Polat, Beyzagül; Halici, Mesut; Keleş, Osman Nuri; Altunkaynak, Zuhal; Göçer, Fatma

doi:10.1016/j.fertnstert.2008.12.016

Cited by 49 publications

(23 citation statements)

References 45 publications

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“…According to our results, β-1,3-D-glucan decreased LPO levels by increasing defense mechanisms such as the activity of SOD enzymes. This may indicate the presence or trend of increasing amounts of superoxide radicals, which could be linked with an enhanced SOD activity [44] . Indeed, the increased SOD activity would also protect tissues from oxidative stress, which reveals that the accumulation of superoxide anion radicals might be responsible for an increased LPO [45] .…”

Section: Discussionmentioning

confidence: 99%

Sıçanlarda Bortezomib İndüklü Karaciğer Hasarında B-1,3-(D)-Glukan’ın Hepatoprotektif Etkileri

Keleş¹,

Can²,

Çığşar³

et al. 2014

Kafkas Univ Vet Fak Derg

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Section: Discussionmentioning

confidence: 99%

Sıçanlarda Bortezomib İndüklü Karaciğer Hasarında B-1,3-(D)-Glukan’ın Hepatoprotektif Etkileri

Keleş¹,

Can²,

Çığşar³

et al. 2014

Kafkas Univ Vet Fak Derg

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“…In these cases, surgical removal of the ovaries is required (Kurtoglu et al, 2014). Ovarian detorsion may lead to increased reactive oxygen species (ROS), depending on the recovery of oxygen in the damaged ischemic tissue cells and oxidative tissue damage caused by reperfusion after ischemia (Kumtepe et al, 2010;Sengul et al, 2013). Malondialdehyde (MDA) is the basic product of polyunsaturated fatty acid peroxidation and is quite a toxic molecule.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on IschemiaReperfusion Injury in Rat Ovary

et al. 2017

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GÖRKEM, Ü.; TOGRUL, C.; SAHIN, I.; COSKUN, B.; OZAT, M.; GÜNGÖR, T. & DEVECI, E.Protective effect of caffeic acid phenethyl ester (cape) on ıschemia-reperfusion ınjury in rat ovary. Int. J. Morphol. 35(1):141-147, 2017. SUMMARY:The aim of this study was to investigate the effects of caffeic acid phenethyl ester (CAPE) as a prophylactic agent on ischemia/reperfusion (I/R) injury in the rat ovary. A total of 28 Wistar rats were divided into 4 equal groups: (I) sham, (II) ischemia, (III) ischemia + reperfusion, and (IV) IR + CAPE. In groups I and II, ovary torsion was not performed and no drug was administered. In group III, 1 hour of ischemia and 2 hours of reperfusion were performed and no drug was given. Ovarian tissue concentrations of malondialdehyde were significantly higher in the torsion and detorsion groups compared with the sham and Cape groups (P<0.005). The detorsion group showed preantral ovarian follicles and luteal folicules around the blood vessels and positive expression of CD34. In the CAPE group the stromal vascular endothelium with weak expression of CD34 was detected in small areas, and the ovarian follicles and the corpus luteum showed negative expression of CD34. In the study, Biochemical and histopathological results of CAPE treatment was considered to torsion-detorsioned the model showed a protective effect against tissue damage.

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“…In other words, not only surgical detorsion of the ovary is a serious intervention, but ischemic injury may also lead to irreversible tissue damage. An ischemic event causes inflammatory reactions including the release of cytokines, free radicals, activation of platelets and apoptosis [5]. The release of free oxygen radicals is critical for the occurrence of postischemic injury [6].…”

Section: Introductionmentioning

confidence: 99%

Biochemical, Histopathological and Immunohistochemical Evaluation of the Protective and Therapeutic Effects of Thymoquinone against Ischemia and Ischemia/Reperfusion Injury in the Rat Ovary

Ural

Tekın²,

Şehitoğlu³

et al. 2015

Gynecol Obstet Invest

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Aim: To evaluate the antioxidant effects of thymoquinone (TQ) and to investigate the biochemical, histopathological and immunohistochemical changes in experimental rat ovarian torsion. Methods: A total of 48 female adult rats were used in this study and randomly divided into 7 groups: (1) sham operation; (2) bilateral 3-hour ovarian ischemia; (3) 3-hour ischemia and 3-hour reperfusion; (4) and (5) rats were administered 20 and 40 mg/kg of TQ, respectively, before 0.5 h of ischemia, and then 3 h of ovarian ischemia was applied; (6) and (7) 3-hour ovarian ischemia was applied; 2.5 h after the induction of ischemia, rats were administered the same doses of TQ; at the end of 3 h of ischemia, a 3-hour reperfusion was applied. Histologic changes under light microscopy, immunoreactivity for anticaspase-3 and serum levels ofmalondialdehyde, interleukin-6, catalase and glutathione peroxidase were noted and compared between the 7 groups. Results: Ischemia and ischemia/reperfusion cause a deterioration of biochemical and histopathological parameters. Administration of TQ seems to reverse these alterations and alleviate the injury. Antioxidant defense mechanisms appear to be enhanced by the administration of TQ. Conclusion: TQ at different doses attenuates ovarian ischemia and ischemia/reperfusion injury in rats.

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Protective effects of telmisartan on ischemia/reperfusion injury of rat ovary: biochemical and histopathologic evaluation

Cited by 49 publications

References 45 publications

Sıçanlarda Bortezomib İndüklü Karaciğer Hasarında B-1,3-(D)-Glukan’ın Hepatoprotektif Etkileri

Sıçanlarda Bortezomib İndüklü Karaciğer Hasarında B-1,3-(D)-Glukan’ın Hepatoprotektif Etkileri

Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on IschemiaReperfusion Injury in Rat Ovary

Biochemical, Histopathological and Immunohistochemical Evaluation of the Protective and Therapeutic Effects of Thymoquinone against Ischemia and Ischemia/Reperfusion Injury in the Rat Ovary

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Protective effects of telmisartan on ischemia/reperfusion injury of rat ovary: biochemical and histopathologic evaluation

Cited by 49 publications

References 45 publications

Sıçanlarda Bortezomib İndüklü Karaciğer Hasarında B-1,3-(D)-Glukan’ın Hepatoprotektif Etkileri

Sıçanlarda Bortezomib İndüklü Karaciğer Hasarında B-1,3-(D)-Glukan’ın Hepatoprotektif Etkileri

Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on Ischemia­Reperfusion Injury in Rat Ovary

Biochemical, Histopathological and Immunohistochemical Evaluation of the Protective and Therapeutic Effects of Thymoquinone against Ischemia and Ischemia/Reperfusion Injury in the Rat Ovary

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Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on IschemiaReperfusion Injury in Rat Ovary