Protective effects of the aqueous extract of<i>Scutellaria baicalensis</i>against acrolein-induced oxidative stress in cultured human umbilical vein endothelial cells

Zhang, Xingwei; Li, Weifen; Li, Weiwei; Ren, Kan-Han; Fan, Chao-Ming; Chen, Yingying; Shen, Yue‐Liang

doi:10.3109/13880209.2010.501803

Cited by 35 publications

(25 citation statements)

References 41 publications

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“…In addition to the inhibition of ROS generation in human neuroblastoma cells, BM treatment also influenced the mitochondrial membrane potential and affected the expression of several redox regulation proteins such as NF-kB, Sirt1, ERK1/2 and p66Shc, leading to a better defense against ACR [123]. Furthermore, a polyphenol-riched Scutellaria baicalensis Georgi (Labiatae) extract was demonstrated to lower the cytotoxicity of ACR in human umbilical vein endothelial cells via increasing GSH content and upregulating the mRNA expression of GSH synthesis enzymes [124]. Moreover, a recent study demonstrated that decaffeinated green tea extract can attenuate cooking-oil-fumes-induced acute lung injury through the suppression of cooking oil fume-induced upregulation of ROS level and the downregualtion of antiapoptosis and chaperone protein in rats [125].…”

Section: Impact On Healthmentioning

confidence: 99%

Acrolein scavengers: Reactivity, mechanism and impact on health

Zhu

Sun

Jiang

et al. 2011

Molecular Nutrition Food Res

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Acrolein (ACR) is an α,β-unsaturated aldehyde that exists extensively in the environment and (thermally processed) foods. It can also be generated through endogenous metabolism. Its high electrophilicity makes this aldehyde notorious for its facile reaction with biological nucleophiles, leading to the modification of proteins/DNA and depletion of glutathione. Recent studies also have revealed its roles in disturbing various cell signing pathways in biological systems. With growing evidences of ACR's implication in human diseases, strategies to eliminate its hazardous impacts are of great importance. One of the intervention strategies is the application of reactive scavengers to directly trap ACR. Some known ACR scavengers include sulfur (thiol)-containing and nitrogen (amino)-containing compounds as well as the newly emerging natural polyphenols. In this review, the interactions between ACR and its scavengers are highlighted. The discussion about ACR scavengers is mainly focused on their chemical reactivity, trapping mechanisms as well as their roles extended to biological relevance. In addition to their direct trapping effect on ACR, these scavengers might possess multiple functions and offer additional benefits against ACR-induced toxicity. A comprehensive understanding of the mechanism involved may help to establish ACR scavenging as a novel therapeutic intervention against human diseases that are associated with ACR and/or oxidative stress.

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Section: Impact On Healthmentioning

confidence: 99%

Acrolein scavengers: Reactivity, mechanism and impact on health

Zhu

Sun

Jiang

et al. 2011

Molecular Nutrition Food Res

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“…Also Scutellaria baicalensis Georgi (Labiatae), one of the 50 fundamental herbs of Chinese herbology, has been reported to restrain ACR-induced toxicity in HUVEC cells, an effect which is strictly associated with increased GSH levels and with elevation of mRNA expressions of GSH synthesis enzymes [135].…”

Section: Indirect Agentsmentioning

confidence: 99%

Protein modification by acrolein: Relevance to pathological conditions and inhibition by aldehyde sequestering agents

Aldini

Orioli

Carini

2011

Molecular Nutrition Food Res

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Acrolein (ACR) is a toxic and highly reactive α,β-unsaturated aldehyde widely distributed in the environment as a common pollutant and generated endogenously mainly by lipoxidation reactions. Its biological effects are due to its ability to react with the nucleophilic sites of proteins, to form covalently modified biomolecules which are thought to be involved as pathogenic factors in the onset and progression of many pathological conditions such as cardiovascular and neurodegenerative diseases. Functional impairment of structural proteins and enzymes by covalent modification (crosslinking) and triggering of key cell signalling systems are now well-recognized signs of cell and tissue damage induced by reactive carbonyl species (RCS). In this review, we mainly focus on the in vitro and in vivo evidence demonstrating the ability of ACR to covalently modify protein structures, in order to gain a deeper insight into the dysregulation of cellular and metabolic pathways caused by such modifications. In addition, by considering RCS and RCS-modified proteins as drug targets, this survey will provide an overview on the newly developed molecules specifically tested for direct or indirect ACR scavenging, and the more significant studies performed in the last years attesting the efficacy of compounds already recognized as promising aldehyde-sequestering agents.

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“…The protective effect of picroside II against hypoxia/ reoxygenation injury in neonatal rat cardiomyocytes injury (Morimoto et al, 2008;Zhang et al, 2011;Shen et al, 2011).…”

Section: Research Articlementioning

confidence: 99%