Protective effects of the pyrolyzates derived from bamboo against neuronal damage and hematoaggregation

Hong, Eui‐Ju; Jung, Eui‐Man; Lee, Geun‐Shik; Kim, Joo Youn; Na, Ki-Jeong; Park, Mi Jin; Kang, Ha‐Young; Choi, Kyung-Chul; Seong, Yeon Hee; Choi, In‐Gyu; Jeung, Eui‐Bae

doi:10.1016/j.jep.2010.01.045

Cited by 30 publications

(12 citation statements)

References 19 publications

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“…P. edulis grows and proliferates rapidly and is considered an invasive species in areas of China due to its ability to overtake biomes [22]. Potential medical uses of compounds and extracts derived from the leaves of P. edulis and other bamboo species have been investigated [23], [24], [25], [26], including possible use towards the treatment of inflammation [27], [28], [29].…”

Section: Introductionmentioning

confidence: 99%

Phyllostachys edulis Compounds Inhibit Palmitic Acid-Induced Monocyte Chemoattractant Protein 1 (MCP-1) Production

et al. 2012

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Background Phyllostachys edulis Carriere (Poaceae) is a bamboo species that is part of the traditional Chinese medicine pharmacopoeia. Compounds and extracts from this species have shown potential applications towards several diseases. One of many complications found in obesity and diabetes is the link between elevated circulatory free fatty acids (FFAs) and chronic inflammation. This study aims to present a possible application of P. edulis extract in relieving inflammation caused by FFAs. Monocyte chemoattractant protein 1 (MCP-1/CCL2) is a pro-inflammatory cytokine implicated in chronic inflammation. Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and activator protein 1 (AP-1) are transcription factors activated in response to inflammatory stimuli, and upregulate pro-inflammatory cytokines such as MCP-1. This study examines the effect of P. edulis extract on cellular production of MCP-1 and on the NF-κB and AP-1 pathways in response to treatment with palmitic acid (PA), a FFA.Methodology/Principal FindingsMCP-1 protein was measured by cytometric bead assay. NF-κB and AP-1 nuclear localization was detected by colorimetric DNA-binding ELISA. Relative MCP-1 mRNA was measured by real-time quantitative PCR. Murine cells were treated with PA to induce inflammation. PA increased expression of MCP-1 mRNA and protein, and increased nuclear localization of NF-κB and AP-1. Adding bamboo extract (BEX) inhibited the effects of PA, reduced MCP-1 production, and inhibited nuclear translocation of NF-κB and AP-1 subunits. Compounds isolated from BEX inhibited MCP-1 secretion with different potencies.Conclusions/SignificancePA induced MCP-1 production in murine adipose, muscle, and liver cells. BEX ameliorated PA-induced production of MCP-1 by inhibiting nuclear translocation of NF-κB and AP-1. Two O-methylated flavones were isolated from BEX with functional effects on MCP-1 production. These results may represent a possible therapeutic application of BEX and its compounds toward alleviating chronic inflammation caused by elevated circulatory FFAs.

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Section: Introductionmentioning

confidence: 99%

Phyllostachys edulis Compounds Inhibit Palmitic Acid-Induced Monocyte Chemoattractant Protein 1 (MCP-1) Production

et al. 2012

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“…All the preparations were able to restore cell viability when compared to untreated cells in an NMDA-induced neuronal cell death assay. Additionally, vinegars of P. pubescens and P. n i g r a showed a reduction of apoptosis following the exposure to NMDA, indicating them as supplements for ischemic injury treatment [54].…”

Section: Miscellaneous Activitiesmentioning

confidence: 95%

Medicinal Properties of Bamboos

Wróblewska¹,

Oliveira²,

Grombone-Guaratini³

et al. 2019

Pharmacognosy - Medicinal Plants

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Bamboos are described as one of the most important renewable, easily obtained, and valuable of all forest resources. These plants belong to the grasses' family (Poaceae), which covers about a quarter of the world's plant population, within the subfamily Bambusoideae. The estimated diversity of bamboos in the world is approximately 1400 species, distributed in 116 genera. Bamboo species have been used in Southeast Asia, as a base material to produce paper, furniture, boats, bicycles, textiles, musical instruments, and food, and their leaves have also been used as a wrapping material to prevent food deterioration since ancient times. These species accumulate biologically active components such as polyphenols and other secondary plant metabolites that might explain the use of bamboo leaves in Asian traditional medicine for the treatment of hypertension, arteriosclerosis, cardiovascular disease, and certain forms of cancer. Besides the usual secondary metabolites, bamboo extracts may contain biologically active peptides and polysaccharides that still need to be further studied for their activity and their synergistic with other metabolites. Most of the studies found in the literature are from Asian bamboo species, and the potential of the Southern American species is yet to be explored.

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“…Os resultados indicam que as espécies de bambu do Brasil aumentam o FPS dos filtros solares comerciais e são seguros para o uso externo, com potencial para a produção de cosméticos fotoprotetores. HWANG; SUNG, 2001, AKAO et al, 2004, HONG et al 2010VARSHNEY, 2018, KIM et al, 2009. Outros efeitos biológicos, como anti-inflamatório, antidiabético, hepatoprotetor e prebiótico foram relacionados com a presença de polissacarídeos específicos (CHEN et al, 2018, HUANG et al, 2017, DING et al, 1998.…”

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“…nigra (HONG et al, 2010). Adicionalmente, foi confirmada a presença dos derivados do eugenol, com reconhecida atividade antimicrobiana (NIELSEN et al, 2018), isoeugenol (1%) e di-hidroeugenol (0,95%).…”

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Atividade antioxidante e fotoprotetora de bambus nativos do Sudeste brasileiro

Wróblewska¹

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Protective effects of the pyrolyzates derived from bamboo against neuronal damage and hematoaggregation

Cited by 30 publications

References 19 publications

Phyllostachys edulis Compounds Inhibit Palmitic Acid-Induced Monocyte Chemoattractant Protein 1 (MCP-1) Production

Phyllostachys edulis Compounds Inhibit Palmitic Acid-Induced Monocyte Chemoattractant Protein 1 (MCP-1) Production

Medicinal Properties of Bamboos

Atividade antioxidante e fotoprotetora de bambus nativos do Sudeste brasileiro

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