Acrylamide (ACR) is a naturally occurring, widely used compound, it is produced during high temperature processing of food by cooking, frying, toasting, roasting or baking of carbohydrate rich foods. Ingestion of large amounts of ACR underlies several health concerns as Neurotoxicity, reproductive toxicity and immunotoxicity. The mechanisms of ACR toxicity are unclear. In this review we tried to clarify that mechanisms especially the disturbance in antioxidant system.