Protective effects of vitamin E on ethane dimethane sulfonate-induced testicular toxicity in rats

Şahıntürk, Varol; Guclu, Canan; Bayçu, Cengiz

doi:10.1111/j.1745-7262.2007.00229.x

Cited by 14 publications

(17 citation statements)

References 21 publications

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“…Vitamin E @ 100 mg/kg b. wt was found to be ineffective to protect testicular tissues against radiation-induced damage. [19] Partial protective role of vitamin E was recorded earlier during ethane dimethane sulfonate-induced[20] testicular toxicity in rats. Vitamin E has been proven to protect testicular tissues against experimental cryptorchidism in rats.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of protective effect of vitamin E on acrylamide induced testicular toxicity in Wister rats

Rahangadale¹,

Jangir²,

Patil³

et al. 2012

Toxicol Int

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Male wistar rats (weighting 160–180 g) were divided in six groups of 6 animals per group. Group A and F served as control. Groups B, C, D and E received acrylamide at 20 mg/kg body weight for 28 days and groups C and E received additionally vitamin E (50 IU/kg body weight) for 1 to 28 days and 29 – 42nd days of experiment, respectively. The animals from groups A, B, and C were sacrificed on day 28th of experiment and from groups D, E, and F on 42nd day of experiment, respectively. There was significant decrease in the total sperm count and significant increase in the dead sperm count on day 28th of study due to acrylamide toxicity. At recovery period, there was significant increase in the total sperm count of vitamin-E-treated group of animals as compared to untreated toxicated rats. But, values were significantly lower than control animals. Microscopically, the lesions in the testes of acrylamide intoxicated rats at 28th day revealed destruction of seminiferous tubules at periphery. No spermatid and spermatocytes were seen in the seminiferous tubules. Detachment of spermatogonial cells started at periphery of seminiferous tubules. Atrophy of seminiferous tubules was a constant finding. Some tubules showed vacuolar degenerative changes in germinal epithelium. During the recovery period, destruction of seminiferous tubules, detachment of spermatogonial cells, and atrophy of seminiferous tubules were observed in group D and E. Few sections revealed only spermatogonial cells. At recovery period vitamin-E-treated rats revealed somewhat better architecture of the seminiferous tubules. Late spermatids were seen in few seminiferous tubules and other revealed starting of spermatogenesis. Thus, it appears that Vitamin E is not able to protect testes from acrylamide toxicity during active feeding, but after cessation of acrylamide feeding treatment with vitamin E revealed faster recovery as compare to not treated group.

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Section: Resultsmentioning

confidence: 99%

Evaluation of protective effect of vitamin E on acrylamide induced testicular toxicity in Wister rats

Rahangadale¹,

Jangir²,

Patil³

et al. 2012

Toxicol Int

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“…In this case, the reduction in volume and weight of testis, diameter of seminiferous tubules, thickness of germinal epithelium, number of sperm, spermatogenesis and the induction of apoptosis in the germ cells are some of the changes that have been reported as the consequences of p-NP exposure [11][12][13][14][15][16]. On the other hand, antioxidants, such as vitamin E, can inhibit reactive oxygen species (ROS) [9,17,18], and thus terminate lipid peroxidation and stabilize the molecular composition of cellular membranes [19]; therefore, it prevents the harmful effects of ROS. In addition, investigations have also shown that the vitamin E prevents toxic damages to testis and sperm after exposure to other chemicals and to γ-radiation [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, antioxidants, such as vitamin E, can inhibit reactive oxygen species (ROS) [9,17,18], and thus terminate lipid peroxidation and stabilize the molecular composition of cellular membranes [19]; therefore, it prevents the harmful effects of ROS. In addition, investigations have also shown that the vitamin E prevents toxic damages to testis and sperm after exposure to other chemicals and to γ-radiation [19][20][21]. As vitamin E is a dietary factor for animal nutrition, which is important for normal reproduction [22], and also its requirement for testicular function is well established [23], therefore, this study was organized to investigate the preventing role of vitamin E as a strong antioxidant in ameliorating the undesired effects of p-NP on the structure of testis in rats treated with p-NP from prenatal to maturation for a period of 90 days.…”

Section: Introductionmentioning

confidence: 99%

Stereological study of the effects of vitamin E on testis structure in rats treated with para-nonylphenol

Mehranjani¹,

Noorafshan²,

Momeni³

et al. 2009

Asian J Androl

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This study was organized to see whether vitamin E, as a strong antioxidant, could affect the abnormalities of testis structure caused by para-nonylphenol (p-NP) during its development. A total of 32 female Wistar rats after mating were divided into four groups (n = 8): control, vitamin E (100 mg kg(-1) per day), p-NP (250 mg kg(-1) per day) and p-NP + vitamin E. The rats were treated from the seventh day of pregnancy till the twenty-first day. After weaning, the male pups were divided into the same groups and were treated orally for 90 days. Finally, the right testis was fixed, processed, stained and studied using stereological methods. The weight and volume of testis, volume of seminiferous tubules and its diameter, thickness of the basement membrane, height of the germinal epithelium, total number of types A and B spermatogonia, spermatocyte, spermatid and Sertoli cells were significantly reduced in p-NP group when compared with other groups. Co-administration of vitamin E and p-NP compensated for the adverse effects of p-NP on the above parameters. In addition, treatment with only vitamin E caused a significant increase in diameter, basement membrane thickness and height of germinal epithelium, number of spermatogonia and spermatocytes. Co-administration of vitamin E with p-NP could prevent the adverse effects of p-NP on the testis structure during its development.

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“…DMSO was used as a vehicle in several in vivo studies. According to Sahinturk, Guclu, and Baycu () “The vehicle (DMSO)‐treated control rats showed the typical morphological organisation of the adult rat testis.” Similarly, Yucra et al. () found no difference between rats treated with DMSO or distilled water.…”

Section: Discussionmentioning

confidence: 99%

Effect of nordihydroguaiaretic acid on spermatogenesis and fertility in rats

Abbas¹,

Badran

Disi

2017

Andrologia

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Nordihydroguaiaretic acid (NDGA) is a naturally occurring lignan with potent antioxidant activity. Currently, it is in clinical trials as anticancer agent. As there is no earlier report on the effect of NDGA on spermatogenesis and fertility, this study was designed to investigate this aspect. Administration of NDGA to rats for 60 days produced degenerative changes in testis but had no effect on sperm DNA integrity test and androgen receptor expression. Ultrastructural studies revealed loss of integrity of cells in seminiferous tubules, vacuolation and presence of apoptotic bodies. Derangement of the outer dense fibres was noted in some sperm flagella. Acrosome formation appears to be normal. About 13.7% of epididymal spermatozoa had deformations like short tail or rounded head. This may explain the lower fertility index in NDGA-treated group. No external deformations in newborns were noted. In conclusion, NDGA may have adverse effects on spermatogenesis.

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Protective effects of vitamin E on ethane dimethane sulfonate-induced testicular toxicity in rats

Abstract: Vit E cotreatment showed partial protective effects on the testicular weight and testicular histology in rats that received EDS.

Cited by 14 publications

References 21 publications

Evaluation of protective effect of vitamin E on acrylamide induced testicular toxicity in Wister rats

Evaluation of protective effect of vitamin E on acrylamide induced testicular toxicity in Wister rats

Stereological study of the effects of vitamin E on testis structure in rats treated with para-nonylphenol

Effect of nordihydroguaiaretic acid on spermatogenesis and fertility in rats

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