Protective Effects of Vitamin Glycosides on γ-radiation and H2O2-Induced Decomposition of Thymine in Aqueous Solutions

Abstract

Effects of ascorbic acid (AA), ascorbic acid glycoside (AAG) and alpha-tocopherol monoglycoside (TMG) on radiation - and H(2)O(2)-induced decomposition of thymine in aqueous solutions were investigated. Of the three compounds studied, AAG was found to possess the most marked protector properties. An explanation of this phenomenon has been given in terms of differences in molecular structures of AA and AAG, as well as properties of radical adducts formed during their interaction with OH radicals.

Effect of γ-radiation on green onion DNA integrity: Role of ascorbic acid and polyphenols against nucleic acid damage

“…In fact, ascorbic acid has proven to be effective against ovalbumin and ovomucoid aggregation and denaturation promoted by c-radiation (Moon & Song, 2001). In addition, several studies have suggested ascorbic acid as protector agent against oxidative damage promoted by c-radiation and it is consistent with the findings here (Jagetia et al, 2004;Mishra, 2004;Shadyro et al, 2008;Wan et al, 2006). These results have important relevance from a nutritional point of view, since even under c-radiation accepted doses for vegetables such as GO, procedure used as a food preservation methodology, their exposure causes an extraordinary decreases in the ascorbic acid content, thus, in their nutritional properties.…”

“…Nevertheless, López-Alarcón et al (Atala, Vasquez, Speisky, Lissi, & López-Alarcón, 2009), have recently reported that one oxygen radical absorbance capacity (ORAC) assay; ORAC-pyrogallol red is suitable to evaluate simultaneously the antioxidant capacity and ascorbic acid content by using peroxyl radicals produced from AAPH thermal decomposition as an oxidant source. This is very important for vegetables rich in ascorbic acid, since this compound has been described as a protecting agent toward thymine oxidation promoted by c-radiation (Shadyro, Lagutin, Edimecheva, Brinkevich, & Kagiya, 2008). Similar to celery or garlic (Prakash et al, 2000), green onions have a high ascorbic acid content and are one of the vegetables commonly exposed to c-radiation in order to extend their shelf-life and eliminate pathogens (Fan et al, 2003).…”

Meteorites and the RNA World: A Thermodynamic Model of Nucleobase Synthesis within Planetesimals

“…Laboratory experiments by Shadyro et al [78] have shown that T decomposes by 18% in just 40 minutes when heated to 120 • C in an aqueous solution of hydrogen peroxide (H 2 O 2 ). H 2 O 2 is found in the spectrum of comet Hale-Bopp in abundances of ∼0.03 mol/100 mol H 2 O [70].…”

Ascorbic acid glucoside reduces neurotoxicity and glutathione depletion in mouse brain induced by nitrotriazole radiosensitazer

“…[17,18] AA-2G produces anti-oxidant and radioprotective effects due to blocking the radiation-induced lipid peroxidation processes and strand breaks in DNA. [19][20][21] We have shown that AA-2G markedly protects from the decrease in blood leukocytes, thymocytes, splenocytes and bone marrow cells in healthy mice administered with high CPA dose (250 mg/kg). [22] The present study was undertaken to investigate the potential of the anti-oxidant ascorbic acid glucoside in comparison with ascorbic acid to modulate sanazole-induced neurotoxicity.…”