Protective effects on myelosuppression mice treated by three different classic chinese medicine formulae

Zhao, An-bin; Yu, Bin; Xian-lin, WU; Cao, Kejiang; Li, En-Qing; Li, Qingmei; Chen, Xiaoyin

doi:10.4103/0973-1296.80671

Cited by 17 publications

(6 citation statements)

References 16 publications

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“…In the present study, the effects of BZ on weightlessness-induced muscle atrophy and its mechanisms were investigated. BZ is additionally commonly used in clinical practice for chronic fatigue and chronic atrophic gastritis, and is widely produced ( 12 ). Large scale epidemiological studies in clinical trials have been conducted, suggesting that BZ has a clear effect on improving muscle function ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

The effect of Bu Zhong Yi Qi decoction on simulated weightlessness-induced muscle atrophy and its mechanisms

Zhu

Liu

Gao

et al. 2017

Molecular Medicine Reports

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Microgravity has been previously demonstrated to induce skeletal muscle atrophy, loss of muscle force and disorders in myogenesis and metabolism. Current pharmacological strategies exhibit poor efficacy. Bu Zhong Yi Qi decoction (BZ) is a well-known traditional Chinese medicine decoction used for myasthenia gravis. In the present study, its effect on unloading induced muscle atrophy was investigated. The mousetail suspension model was used to simulate weightlessness induced muscle atrophy. The results indicated that BZ could significantly protect muscles from simulated weightlessness-induced atrophy. To elucidate the underlying mechanisms, drugCIPHER-CS methods were introduced to predict its potential targets, significantly enriched pathways and biological processes. The results demonstrated that the calcium signaling pathway, citrate cycle, biosynthetic and lipid metabolic process are affected by BZ. Among the targets, nuclear receptor corepressor 1 (NCoR1) is one of the most important proteins involved in myogenesis and metabolism. The results indicated that BZ significantly downregulated NCoR 1 expression, and further induced muscle differentiation and metabolism by regulating NCoR1-associated gene expression in vivo and in vitro. In summary, the present study indicated that may be effective in combating weightlessness-induced muscle atrophy. Combined with bioinformatics, the underlying mechanism for this decoction was investigated, which provided an improved understanding of this decoction.

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Section: Introductionmentioning

confidence: 99%

The effect of Bu Zhong Yi Qi decoction on simulated weightlessness-induced muscle atrophy and its mechanisms

Zhu

Liu

Gao

et al. 2017

Molecular Medicine Reports

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“…Few developing HSCs could be observed, most of which exhibited pyknotic nuclei. Similarly, other researchers reported that CY injection caused significant decrease in bone marrow cell counts ( 15 ).…”

Section: Discussionmentioning

confidence: 73%

“…On the other hand, the lowest % of CD34 +ve cells was detected in gIIa (CY only). Previous investigations revealed that AM accelerated bone marrow haemopoietic stem progenitor cells in marrow-suppressed mice and enhanced cell proliferation by promoting cell cycles from G0/G1 phase to access into S, G2 phases ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

Myelo-Enhancement by Astragalus Membranaceus in Male Albino Rats with Chemotherapy Myelo-Suppression. Histological and Immunohistochemical Study

et al. 2014

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Background and Objectives: Myelo-suppression is the most common toxicity encountered in the oncology clinic today.This study was planned to investigate the possible protective and therapeutic role of the traditional Chinese Medicinal Herb; Astragalus Membranaceus (AM), on chemotherapy-induced myelosuppression. Methods and Results: This study was carried out on thirty six adult male albino rats. They were divided into: Group I Control Group (n=6) received a vehicle of phosphate buffered saline (PBS) solution. Group II (n=12) were injected I.P. with cyclophosphamide (CY) for 3 days (gIIa n =6) and continued for one more week to receive AM orally (gIIb n=6). Group III (n=6) received CY I.P. together with AM orally for 3 days. Group IV (n=12) received AM orally for one week (gIVa n=6) and continued for extra three days receiving CY I.P. with AM orally (gIVb n=6). Blood samples were analysed for Total Leucocytic Count and Lymphocytic Count. Counting of CD34 +ve cells in bone marrow was performed by flowcytometry. Bone marrow sections were subjected to H&E stain as well as immunohistochemical staining for anti-CD20 antibody. The mean area % of cellular bone marrow regions occupied by developing haemopoietic cells, mean area of fat cells and mean number of CD20 immunopositive B lymphocytes in the bone marrow were measured by histomorphometric studies and statistically compared. AM proved to have a myelo-protective and myelo-therapeutic capacity, evidenced at both laboratory and morphological levels. Conclusions: The greatest myelo-potentiating effect of AM was achieved when supplied before and together with CY therapy.

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“…Myelosuppression is a significant side effect of most chemotherapeutic and radiotherapeutic agents [1], leading to decreased red and white blood cell populations [2] and potential immunosuppression [3]. Fatal infections may occur in severe cases [4]. Thus, myelosuppression significantly affects patient outcomes.…”

Section: Introductionmentioning

confidence: 99%

The Involvement of Macrophage Colony Stimulating Factor on Protein Hydrolysate Injection Mediated Hematopoietic Function Improvement

Wang

Zhang

Meng

et al. 2021

Cells

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Protein hydrolysate injection (PH) is a sterile solution of hydrolyzed protein and sorbitol that contains 17 amino acids and has a molecular mass of 185.0–622.0 g/mol. This study investigated the effect of PH on hematopoietic function in K562 cells and mice with cyclophosphamide (CTX)-induced hematopoietic dysfunction. In these myelosuppressed mice, PH increased the number of hematopoietic cells in the bone marrow (BM) and regulated the concentration of several factors related to hematopoietic function. PH restored peripheral blood cell concentrations and increased the numbers of hematopoietic stem cells and progenitor cells (HSPCs), B lymphocytes, macrophages, and granulocytes in the BM of CTX-treated mice. Moreover, PH regulated the concentrations of macrophage colony stimulating factor (M-CSF), interleukin (IL)-2, and other hematopoiesis-related cytokines in the serum, spleen, femoral condyle, and sternum. In K562 cells, the PH-induced upregulation of hematopoiesis-related proteins was inhibited by transfection with M-CSF siRNA. Therefore, PH might benefit the BM hematopoietic system via the regulation of M-CSF expression, suggesting a potential role for PH in the treatment of hematopoietic dysfunction caused by cancer therapy.

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Protective effects on myelosuppression mice treated by three different classic chinese medicine formulae

Cited by 17 publications

References 16 publications

The effect of Bu Zhong Yi Qi decoction on simulated weightlessness-induced muscle atrophy and its mechanisms

The effect of Bu Zhong Yi Qi decoction on simulated weightlessness-induced muscle atrophy and its mechanisms

Myelo-Enhancement by Astragalus Membranaceus in Male Albino Rats with Chemotherapy Myelo-Suppression. Histological and Immunohistochemical Study

The Involvement of Macrophage Colony Stimulating Factor on Protein Hydrolysate Injection Mediated Hematopoietic Function Improvement

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