Protective efficacy of a hydroxy fatty acid against gastric <i>Helicobacter</i> infections

Matsui, Hidenori; Takahashi, Takuya; Murayama, Somay Yamagata; Kawaguchi, Masashi; Matsuo, Koichi; Nakamura, Masahiko

doi:10.1111/hel.12430

Cited by 23 publications

(26 citation statements)

References 40 publications

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“…A mixture of 10-HFAs was patented as an intestinal tract protecting agent [22] while 10-hydroxystearic acid proved to ameliorate skin age spots and conspicuous pores [23]. Fatty acid esters of 13-hydroxy linoleic acid are anti-inflammatory [24]: 9-hydroxystearic acid (9-HSA) shows anticancer properties [25] whereas (12Z)-10-hydroxy-octadecenoic acid possesses antifungal properties [26] and is able to prevent gastric Helicobacter infections by blocking their futalosine pathways [27]. In addition, recent studies have demonstrated that HFAs produced by human gut bacteria play a relevant role in the control of allergy, inflammation, and immunity, pointing to the involvement of their metabolites in the so-called gut-skin axis [28,29].…”

Section: Introductionmentioning

confidence: 99%

The Fatty-Acid Hydratase Activity of the Most Common Probiotic Microorganisms

Serra¹,

Simeis²,

Castagna³

et al. 2020

Catalysts

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In this work, we studied the biotechnological potential of thirteen probiotic microorganisms currently used to improve human health. We discovered that the majority of the investigated bacteria are able to catalyze the hydration reaction of the unsaturated fatty acids (UFAs). We evaluated their biocatalytic activity toward the three most common vegetable UFAs, namely oleic, linoleic, and linolenic acids. The whole-cell biotransformation experiments were performed using a fatty acid concentration of 3 g/L in anaerobic conditions. Through these means, we assessed that the main part of the investigated strains catalyzed the hydration reaction of UFAs with very high regio- and stereoselectivity. Our biotransformation reactions afforded almost exclusively 10-hydroxy fatty acid derivatives with the single exception of Lactobacillus acidophilus ATCC SD5212, which converted linoleic acid in a mixture of 13-hydroxy and 10-hydroxy derivatives. Oleic, linoleic, and linolenic acids were transformed into (R)-10-hydroxystearic acid, (S)-(12Z)-10-hydroxy-octadecenoic, and (S)-(12Z,15Z)-10-hydroxy-octadecadienoic acids, respectively, usually with very high enantiomeric purity (ee > 95%). It is worth noting that the biocatalytic capabilities of the thirteen investigated strains may change considerably from each other, both in terms of activity, stereoselectivity, and transformation yields. Lactobacillus rhamnosus ATCC 53103 and Lactobacillus plantarum 299 V proved to be the most versatile, being able to efficiently and selectively hydrate all three investigated fatty acids.

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Section: Introductionmentioning

confidence: 99%

The Fatty-Acid Hydratase Activity of the Most Common Probiotic Microorganisms

Serra¹,

Simeis²,

Castagna³

et al. 2020

Catalysts

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“…A number of free fatty acids (FFAs), with potent antibacterial activities against a broad range of bacteria (18)(19)(20)(21), including H. pylori, are of considerable research interests. In particular, FFAs seem to induce no acquired resistance to the antibacterial effect and are considered safe, which make them attractive as antibacterial agents for commercial exploitation.…”

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confidence: 99%

In Vitro and In Vivo Activities of Zinc Linolenate, a Selective Antibacterial Agent against Helicobacter pylori

Huang

Hang

Jiang

et al. 2019

Antimicrob Agents Chemother

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Helicobacter pylori is a major global pathogen, and its infection represents a key factor in the etiology of various gastric diseases, including gastritis, peptic ulcers, and gastric carcinoma. The efficacy of current standard treatment for H. pylori infection including two broad-spectrum antibiotics is compromised by toxicity toward the gut microbiota and the development of drug resistance, which will likely only be resolved through novel and selective antibacterial strategies. Here, we synthesized a small molecule, zinc linolenate (ZnLla), and investigated its therapeutic potential for the treatment of H. pylori infection. ZnLla showed effective antibacterial activity against standard strains and drug-resistant clinical isolates of H. pylori in vitro with no development of resistance during continuous serial passaging. The mechanisms of ZnLla action against H. pylori involved the disruption of bacterial cell membranes and generation of reactive oxygen species. In mouse models of multidrugresistant H. pylori infection, ZnLla showed in vivo killing efficacy comparable and superior to the triple therapy approach when use as a monotherapy and a combined therapy with omeprazole, respectively. Moreover, ZnLla treatment induces negligible toxicity against normal tissues and causes minimal effects on both the diversity and composition of the murine gut microbiota. Thus, the high degree of selectivity of ZnLla for H. pylori provides an attractive candidate for novel targeted anti-H. pylori treatment.

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“…plantarum into dairy products could lead to the production of such a therapeutic agent. Recently, the antimicrobial activity of HYA has been reported against Helicobacter pylori (Matsui et al., 2017). There is no study on the antibacterial effects of HYA against foodborne pathogens and spoilage microorganisms.…”

Section: Food Applications Of Postbioticsmentioning

confidence: 99%

Postbiotics produced by lactic acid bacteria: The next frontier in food safety

Moradi

Kousheh

Almasi

et al. 2020

Comp Rev Food Sci Food Safe

195

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There are many critical challenges in the use of primary and secondary cultures and their biological compounds in food commodities. An alternative is the application of postbiotics from the starter and protective lactic acid bacteria (LAB). The concept of postbiotics is relatively new and there is still not a recognized definition for this term. The word "postbiotics" is currently used to refer to bioactive compounds, which did not fit to the traditional definitions of probiotics, prebiotics, and paraprobiotics. Therefore, the postbiotics may be presently defined as bioactive soluble factors (products or metabolic byproducts), produced by some food-grade microorganisms during the growth and fermentation in complex microbiological culture (in this case named cell-free supernatant), food, or gut, which exert some benefits to the food or the consumer. Many LAB are considered probiotic and their postbiotic compounds present similar or additional health benefits to the consumer; however, this review aimed to address the most recent applications of the postbiotics with food safety purposes. The potential applications of postbiotics in food biopreservation, food packaging, and biofilm control were reviewed. The current uses of postbiotics in the reduction and biodegradation of some food safety-related chemical contaminants (e.g., biogenic amines) were considered. We also discussed the safety aspects, the obstacles, and future perspectives of using postbiotics in the food industry. This work will open up new insights for food applications of postbiotics prepared from LAB.

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Protective efficacy of a hydroxy fatty acid against gastric Helicobacter infections

Abstract: HYA prevents gastric Helicobacter infections by blocking their futalosine pathways. Daily HYA supplementation is effective for the prevention of gastric mucosa-associated lymphoid tissue lymphoma induced by persistent infection with H. suis.

Cited by 23 publications

References 40 publications

The Fatty-Acid Hydratase Activity of the Most Common Probiotic Microorganisms

The Fatty-Acid Hydratase Activity of the Most Common Probiotic Microorganisms

In Vitro and In Vivo Activities of Zinc Linolenate, a Selective Antibacterial Agent against Helicobacter pylori

Postbiotics produced by lactic acid bacteria: The next frontier in food safety

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