2012
DOI: 10.5455/oams.200812.or.014
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Protective efficacy of garlic on cadmium induced oxidative stress in young and adult rats

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Cited by 6 publications
(4 citation statements)
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“…Oral administration of AGE prior to and after CP significantly reduced its toxic effect on serum levels of AST & ALT enzymes compared to untreated rats. In agree with results of the present study, administration of AGE caused a significant reduction in the serum levels of AST & ALT in rats treated with cadmium [33] ; lead [34] and doxorubicin [10] . The reduction of the liver enzymes in AGE pre-treated rats may be due to its antioxidant effect that reduces the free radical-induced oxidative damage in the liver, thereby stabilizing the membrane permeability and reducing the leakage of enzymes into the blood [18] .…”
Section: Discussionsupporting
confidence: 93%
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“…Oral administration of AGE prior to and after CP significantly reduced its toxic effect on serum levels of AST & ALT enzymes compared to untreated rats. In agree with results of the present study, administration of AGE caused a significant reduction in the serum levels of AST & ALT in rats treated with cadmium [33] ; lead [34] and doxorubicin [10] . The reduction of the liver enzymes in AGE pre-treated rats may be due to its antioxidant effect that reduces the free radical-induced oxidative damage in the liver, thereby stabilizing the membrane permeability and reducing the leakage of enzymes into the blood [18] .…”
Section: Discussionsupporting
confidence: 93%
“…Due to its ability to reduce free radical-induced oxidative damage in the liver and to scavenge the hydroxyl and peroxyl radicals, AGE has been shown to improve the histopathological changes of the damaged liver cells [37] . Moreover, AGE or garlic powder were used to protect the liver against different other toxic agents including lead [34] ; cadmium [33] . In addition, Alkreathy et al [10] reported that AGE ameliorated the toxic effect of doxorubicin on the heart muscle in rats.…”
Section: Discussionmentioning
confidence: 99%
“…The reduction was significant in groups receiving AGE at a dosage of 25 mg/kg compare to those receiving it at a dosage of 50 mg/kg or to those receiving Vitamin E and Lipoïc Acid after irradiation. This reduction of the liver enzymes following AGE intake in the serum levels of AST and ALT was also noticed by other authors [66][67][68] then Nada and Hawas observed it as well with the administration of other herbal plants [69]. According to Pradeep et al, free radical induced oxidative damage in the liver but the antioxidants of AGE decrease the lowering of liver enzymes by stabilizing the membrane permeability and reducing the leakage of enzymes into the blood [70].…”
Section: Discussionsupporting
confidence: 66%
“…From a practical nutritional point of view it is important to examine food products containing significant amounts of antioxidant components in order to use them in a daily diet to prevent the hazardous effect of toxic metals on the human body. In available literature positive effects have been reported, among other things, for garlic, honey, rosemary and green tea (Abdel-Moneim and Ghafeer 2007 ; El Kader et al 2012 ; Hamed et al 2010 ; Padalko et al 2012 ). Tea, as the most popular drink in the world apart from water, deserves particular attention (Hicks 2009 ).…”
Section: Introductionmentioning
confidence: 99%