Protective function of extrinsic sensory neurons in acute rabbit experimental colitis

The proximodistal aggravation of colitis depends on substance P released from TRPV1-expressing sensory neurons

“…In accordance with our results from RTX, systemic capsaicin-induced desensitization ameliorated rat DSS and rat/rabbit trinitrobenzenesulfonic acid solution (TNBS) colitis [10,34,35]. Pharmacological blockage of the SP high-affinity receptor NK1 using SR14033 and CP-96345, showed protective effects in rat TNBS and DSS colitis [7,9,36], however, another NK1 antagonist was reported ineffective in rat TNBS colitis [37,38].…”

Effect of intestinal inflammation on capsaicin-sensitive afferents in the ileum of Schistosoma mansoni -infected mice

“…*** P<0.001 lations of intrinsic peptidergic nerves (vasoactive intestinal polypeptide and SP) in the GI tract of S. mansoniinfected mice. In addition, it has been postulated that extrinsic sensory neurons in the rat and rabbit GI tract have a protective role in experimental colitis by release of CGRP, which modulates vascular tone and mucosal blood flow (Reinshagen et al 1994(Reinshagen et al , 1998. Furthermore, it has been shown that vagal afferent nerve fibers make contact with mast cells (Williams et al 1997) and play a protective role in colonic injury in the intestine of rats with experimentally induced colitis (Mazelin et al 1998(Mazelin et al , 1999.…”

Systemic capsaicin inhibits neuronal activation in the brainstem during postoperative ileus in the mouse

“…Reinshagen et al also previously observed this indeed in a rat colitis model. The effect was explained by the possible protective actions of the extrinsic sensory neuropeptides such as CGRP or Substance P [25,26], which are up-regulated in peripheral capsaicin-sensitive nerve terminals during inflammation [8,23]. In the context of postoperative ileus, this increased inflammatory response after ablation of intestinal afferents by capsaicin may be particularly important as intestinal inflammation is likely to contribute to prolonged postoperative ileus.…”