Protective immune response against foot-and-mouth disease

McCullough, Kenneth C.; Simone, Franco; Brocchi, Emiliana; Capucci, Lorenzo; Crowther, John R.; Kihm, U

doi:10.1128/jvi.66.4.1835-1840.1992

Cited by 197 publications

(71 citation statements)

References 19 publications

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“…However, when the multivariable logistic regression model was retested with village as a fixed effect, there was no significant difference in the titres between villages. This supports the view that vaccineinduced immunity is of short duration, as reported in the literature (Van Maanen and Terpstra, 1989;McCullough et al, 1992). The pre-vaccination anti-SP titres in this study are considered more likely due to previous exposure to FMDV during the 2008-2009 or 2010 outbreaks, rather than the result of vaccination almost 2 years prior to this study.…”

Section: Strategic Vaccination Programmessupporting

confidence: 91%

Investigation of Foot and Mouth Disease hotspots in northern Lao PDR

Nampanya

Richards

Khounsy

et al. 2012

Transboundary and Emerging Diseases

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Summary Foot and mouth disease (FMD) is an endemic transboundary disease in the Mekong region, and FMD records of reports to animal health authorities in Lao PDR between 2009 and 2011 were reviewed. FMD outbreaks occurred in 2 of 3 years in eight districts in three of the eight northern Lao PDR provinces, locations suggested as FMD ‘hotspots’. The relatively higher risk of recurrence of FMD in these districts was likely due to the presence of a dense large ruminant population, extensive animal trading including transboundary movements and ineffective animal movement controls. As an understanding of the epidemiology of FMD in these ‘hotspots’ may offer insights into improved FMD control in the region, a study of an outbreak of FMD occurring in early 2010 following failure to vaccinate was conducted in the endemic ‘hotspot’ area of Paek district in Xiengkhoung province where in early 2009, a major outbreak of FMD in the district had been prevented in two villages by vaccination. The 2010 outbreak included collection of tissue samples 1 week after the onset of FMD that confirmed infection with FMD virus serotype O (Myanmar topotype) in a population of 239 large ruminants, comprising 167 cattle and 72 buffalo. A survey by interview of 30 farmers conducted in July 2010 documented high morbidity in cattle and buffalo (>90%) and identified disease risk factors, including increased trading of animals at the end of the rice harvest, plus several failures of biosecurity. In late 2010 and early 2011, a total of 40 and 72 serum samples were collected from large ruminants prior to and post‐FMD vaccination respectively and tested by LPB‐ELISA. Antibodies were present in the pre‐vaccination samples attributable to previous exposure to FMD virus and significantly rising post‐vaccination titres indicated likely temporary protection against future FMDV infection. It was concluded that to provide sufficient control of FMD in this ‘hotspot’, regular vaccination, particularly prior to the peak risk period in December‐February, plus improved farmer knowledge of disease transmission risk and biosecurity, is required. Although low rural education standards and language barriers because of multiple ethnic groups pose a challenge for the successful delivery of extension programmes in northern Lao PDR, training to improve disease recognition and reporting plus village‐level biosecurity practices is considered important in FMD ‘hotspots’ if sustainable regional initiatives directed at FMD control are to be achieved.

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Section: Strategic Vaccination Programmessupporting

confidence: 91%

Investigation of Foot and Mouth Disease hotspots in northern Lao PDR

Nampanya

Richards

Khounsy

et al. 2012

Transboundary and Emerging Diseases

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“…In silica-treated mice, neutralizing antibody concentrations well over the 90% neutralization titers were required for protection, indicating that in the absence of phagocytosis, protection correlates with neutralization of all the challenge virus. It is likely that efficient protection against FDMV infection by neutralizing antibody at low occupancy is provided by an efficient phagocytosis of sensitized virions, as has been demonstrated for FDMV in vitro (McCullough et al, 1988(McCullough et al, , 1992.…”

Section: J Orthomyxoviruses-influenza Virusmentioning

confidence: 92%

The antiviral activity of antibodies in vitro and in vivo

Parren

Burton

2001

Advances in Immunology

236

191

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“…The effects of ECMS on IgG isotypes IgG1, IgG2a, IgG2b and IgG3 to FMDV serotypes O and Asia I are shown in observed that a FMD DNA vaccine inducing an immune response in mice can also elicit protection in swine against FMD infection. Humoral immune response has been reported as an important defense mechanism against FMD virus (26,27), and the contribution of antibodies to the major immune defense against the virus is clear (28,29).…”

Section: Fmdv (Serotypes O and Asia I)-specific Igg Isotypesmentioning

confidence: 99%

Effect of the extract made fromCochinchina momordicaseeds on the humoral immune responses of mice to a commercial foot-and-mouth disease vaccine (serotypes O and Asia 1)

Sakwiwatkul

Song

et al. 2010

Microbiology and Immunology

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The extract from ECMS was investigated for its effect on the humoral immune responses to foot-andmouth disease vaccination. Fifty-six mice were randomly divided into seven groups with eight animals in each. Mice in groups 5 to 7 were subcutaneously (s.c.) injected with 0.5 mg DEX daily for 4 days to induce immunosuppression. The animals were then orally given ECMS (200 μg in 250 μl saline) in groups 3 and 6 or 250 μl saline in group 2, or s.c. injected with ECMS (50 μg in 100 μl saline) in groups 4 and 7 or 100 μl saline in group 5. After that, the animals in groups 2 to 7 were s.c. Foot-and-mouth disease is caused by FMDV, which is the prototype member of the Aphthovirus genus, Picornaviridae (1) and occurs as seven major serotypes: A, O, C, Asia 1, SAT 1, SAT 2 and SAT 3, but a large number of subtypes are found within each serotype (2, 3). The disease mainly affects the cloven-hoofed animals. FMD has been recorded as one of the most important animal diseases in the world by the World Organization for Animal Health (OIE) due to the rapid transmission of FMDV among susceptible animals (4). Vaccination is a common practice against FMD in many countries. However, failure to elicit effective immune responses by vaccination has been frequently reported (5-7). In agreement with this, Hao et al. (8) observed that only 31.9% out of 91 pigs vaccinated against FMD (type O) produced serum antibody titers needed for immune protection. Hence, currently available vaccines should be improved in order to effectively prevent infectious diseases in animals. Higher dosage of vaccine

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Protective immune response against foot-and-mouth disease

Cited by 197 publications

References 19 publications

Investigation of Foot and Mouth Disease hotspots in northern Lao PDR

Investigation of Foot and Mouth Disease hotspots in northern Lao PDR

The antiviral activity of antibodies in vitro and in vivo

Effect of the extract made fromCochinchina momordicaseeds on the humoral immune responses of mice to a commercial foot-and-mouth disease vaccine (serotypes O and Asia 1)

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