Protective immunity against Echinostoma caproni in rats is induced by Syphacia muris infection

Trelis, María; Cortés, Alba; Fried, Bernard; Marcilla, Antonio; Esteban, J. Guillermo; Toledo, Rafael

doi:10.1016/j.ijpara.2012.12.009

Cited by 13 publications

(12 citation statements)

References 44 publications

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“…Recently, Trelis et al . showed that the nematode Syphacia muris induces change in the glycosylation patterns in the ileum of infected rats, which consist of incremental levels of GlcNAc and GalNAc residues, and it may be important in the resistance against superimposed infection with E. caproni observed in rats previously infected with this nematode. However, our results suggest that these mechanisms are not effective for the expulsion of E. caproni , at least in primary infections.…”

Section: Discussionmentioning

confidence: 99%

“…In C3H mice, the related echinostome species E. trivolvis expulsion increases the expression of GalNAc and a-L-Fucose residues on the surface of the intestinal villi and an appear to mediate the rapid expulsion of E. caproni in an heterologous secondary infection (5,45). Recently, Trelis et al (46) showed that the nematode Syphacia muris induces change in the glycosylation patterns in the ileum of infected rats, which consist of incremental levels of GlcNAc and GalNAc residues, and it may be important in the resistance against superimposed infection with E. caproni observed in rats previously infected with this nematode. However, our results suggest that these mechanisms are not effective for the expulsion of E. caproni, at least in primary infections.…”

Section: Discussionmentioning

confidence: 99%

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Echinostoma caproni (Trematoda): differential in vivo mucin expression and glycosylation in high‐ and low‐compatible hosts

Cortés

Muñoz-Antolí

Sotillo

et al. 2014

Parasite Immunology

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Enhanced mucus production and release appears to be a common mechanism for the clearance of intestinal helminths, and this expulsion is normally mediated by Th2-type immune responses. To investigate the factors determining the expulsion of intestinal helminths, we have analysed in vivo expression of mucin genes at the site of infection in two host species displaying different compatibility with Echinostoma caproni (Trematoda). Surprisingly, a general down-regulation on mucin mRNA expression was detected in low-compatible hosts (rats) coinciding with the development of Th2/Th17 responses and the early rejection of the worms from the intestinal lumen. This suggests the existence of a mechanism by which the parasites can modulate the mucus barrier to favour their survival. In highly compatible hosts (mice), some mucin genes were found to be up-regulated throughout the infection, probably, to protect the intestinal epithelium against the infection-induced inflammation developed in this host species. Moreover, infection-induced changes on mucin glycans were also studied by lectin histochemistry. Similar alterations were detected in the ileum of infected mice and rats, except with SNA lectin, indicating that sylated mucins might play an important role in determining the evolution of the infection in each host species.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Echinostoma caproni (Trematoda): differential in vivo mucin expression and glycosylation in high‐ and low‐compatible hosts

Cortés

Muñoz-Antolí

Sotillo

et al. 2014

Parasite Immunology

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“…In the 21 th century, this group has used the E. caproni-rodent model to study the hostparasite relationships in intestinal helminth infections with emphasis on the factors determining worm rejection or, in contrast, the development of chronic infections. These studies have allowed these workers to delimit the immunological parameters that determine the outcome of the infection providing essential new insights in the factors determining the natural expulsion of intestinal parasitic helminths from their hosts Muñoz-Antoli et al, 2007;Sotillo et al, 2007Sotillo et al, , 2010aTrelis et al, 2011Trelis et al, , 2013. Recently, Muñoz-Antoli et al (2014) reported the regeneration of the intestinal tissue as a major effector mechanism responsible for the early expulsion of echinostomes and, probably, other intestinal helminths.…”

Section: Late 20 Th Century and Early 21 Th Centurymentioning

confidence: 99%

History of echinostomes (Trematoda)

Toledo

Radev

Kanev

et al. 2014

Acta Parasitologica

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Echinostomatidae (Trematoda) is the largest family within the class Trematoda. Members of this family have been studied for many years in relation to their utility as basic research models in biodiversity and systematics and also as experimental models in parasitology since they offer many advantages. Echinostomes have contributed significantly to numerous developments in many areas studied by parasitologists and experimental biologists. In this review, we examine the history of the echinostomebased studies from the beginnings to the present. For this purpose, we have divided the history of echinostomes into four periods (i.e. 18 th and 19 th centuries, first half of the 20 th century, second half of the 20 th century and the late 20 th and 21 th century) according to the types of studies performed in each of them. Moreover, we also briefly review the history of echinostome infections in humans.

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“…The direct transmission of these gastrointestinal (GI) nematodes by contaminated food, water, and bedding leads to continual exposure to the parasite, making the control of pinworms in animal holdings quite difficult (Taffs 1976). Syphacia muris commonly infects rats in laboratories at high prevalence even in well managed habitats (Perec-Matysiak, Okulewicz, Hildebrand, & Zalesny, 2006) and can interfere with the development of unrelated biological disorders (Trelis, Cortés, Fried, Marcilla, Esteban, et al, 2013). Screening for compounds of natural sources for anthelmintic activity, remains take great interest of scientists despite extensive use of synthetic chemicals in modern clinical practices all over the world (Verma, Gaherwal, Kanhere, & Prakash, 2014).…”

Section: Introductionmentioning

confidence: 99%

Effect of bryostatin-1 as an anthelmintic drug on adult Syphacia muris infection in rats

Harras

Mona

Abdalla

et al. 2017

JoBAZ

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Background: The fact that many laboratory rodent colonies were found to be parasite contaminated suggests a need for eradication to improve their quality for research and testing. However, the most anthelmintic are poisonous, and their application always entails some hazards to the host and interferes with the interpretation of the final results. The use of bryostatin as a potential anthelmintic drug is still a matter of controversy. Therefore, the present work was designed to examine the naturally extracted product bryostatin-1 from a marine bryozoan as a possible anthelmintic agent against Pinworms Syphacia muris. Results: Light and scanning electron microscopy revealed normal appearance of worms collected from the infected groups with S. muris and untreated by bryostatin-1, while those collected from the bryostatin-1 treated rats revealed drastic morphological changes in the mouth parts, anus, and cuticle of all treated worms. Significant effects of bryostatin-1 on Syphacia infection were also detected in rats regarding the final body weights, average food consumption, and organ weights. Moreover, the drug has also improved the serum biochemical changes significantly in the infected rats nearly to the normal levels. Conclusions: The study has provided morphological evidence of obvious effect of bryostatin-1 on the movement and feeding behavior of the parasite that lead to consequent weakness and death as well as improvement of the biochemical changes in the infected rats. The present study concluded that bryostatin-1 can be used as anthelmintic agent, although further studies are needed to insure the drug efficacy.

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Protective immunity against Echinostoma caproni in rats is induced by Syphacia muris infection

Cited by 13 publications

References 44 publications

Echinostoma caproni (Trematoda): differential in vivo mucin expression and glycosylation in high‐ and low‐compatible hosts

Echinostoma caproni (Trematoda): differential in vivo mucin expression and glycosylation in high‐ and low‐compatible hosts

History of echinostomes (Trematoda)

Effect of bryostatin-1 as an anthelmintic drug on adult Syphacia muris infection in rats

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