Protective Immunity against Tetrathyridia of Mesocestoides corti by Passive Transfer of Serum in Mice

Kowalski, John C.; Thorson, Ralph E.

doi:10.2307/3278080

Cited by 16 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This tissue contains the usual complement of white blood cells and in rats has been shown to contain numerous mast cells of both gut and connective tissue phenotypes (Chernin & McLaren, 1983;Chernin et al 1988). Kowalski & Thorenson (1972) suggested that the tetrathyridia invade the liver almost immediately after the initial infection and as the immune response within the liver builds up they ' escape' back into the peritoneal cavity. However, this study suggests that there is a continuous entry to and possibly departure from the liver throughout the infection.…”

Section: Discussionmentioning

confidence: 99%

The effect of the tetrathyridia of Mesocestoides corti on the livers and peripheral blood of three different strains of mice

Riley

Chernin²

1994

Parasitology

View full text Add to dashboard Cite

Three strains of male and female mice, CFLP, BALB/c and CBA/ca, were infected i.p. with the tetrathyridia of Mesocestoides corti and examined in groups of 5 at 0, 7, 14, 21, 28 and 42 days post-infection. At post-mortem the numbers of parasites both loose in the peritoneal cavity and in the liver tissue were counted, the livers weighted fresh and sections of liver stained to examine the inflammatory response, encapsulation of the tetrathyridia and for eosinophils, neutrophils, mast cells and plasma cells. BALB/c mice had significantly more parasites loose in the peritoneal cavity than CFLP and CBA/ca mice. Infected livers of all three strains were significantly heavier than control livers; the heaviest livers were those of the CFLP followed by the CBA/ca mice which also showed the greatest rate of weight increase. The tetrathyridia from the peritoneal cavities of the CBA/ca and CFLP mice were covered with a 'mucilage-like' substance. Tetrathyridia within the host capsules of the CBA/ca mice contained host cells. There was no strain difference with regard to numbers of tetrathyridia in the liver but male mice harboured significantly more parasites than females. Differences in the numbers of cell types within the liver were detected between the strains but no one strain showed any consistent pattern. There was an overall increase in total white blood counts as well as an increase in the number of eosinophils, monocytes, neutrophils and lymphocytes during the course of the infection.

show abstract

Section: Discussionmentioning

confidence: 99%

The effect of the tetrathyridia of Mesocestoides corti on the livers and peripheral blood of three different strains of mice

Riley

Chernin²

1994

Parasitology

View full text Add to dashboard Cite

show abstract

“…A number of studies using athymic mice (Pollacco et al 1978) or various immunosuppressive treatments such as irradiation, splenectomy, cyclophosphamide and corticosteroids (White, Thompson & Penhale, 1983 ;Novak, 1975) have all shown that reduced immunological responsiveness results in increased parasite burdens. Conversely, resistance can be enhanced by vaccination with parasite antigens (Kowalski & Thorson, 1972), transfer of immune spleen cells (Novak, 1977) or serum (Kowalski & Thorson, 1972) and by immunomodulators such as BCG (White, Thompson & Penhale, 1988). The data presented here imply that the immunological processes operating to regulate parasite growth in M. corti infections either do not involve eosinophils as major effector cells, or that their function is dependent upon some other immune component.…”

Section: Discussionmentioning

confidence: 99%

Genetic influences upon eosinophilia and resistance in mice infected withMesocestoides corti

1990

View full text Add to dashboard Cite

The genetic influences upon host variation in eosinophilia and resistance to helminth infection, and the relationship between these parameters, was investigated in 9 inbred and 3 hybrid strains of mice infected with Mesocestoides corti. Blood, bone marrow, spleen and peritoneal fluid eosinophilia were far higher in SJL mice than in any other inbred strain. SWR, NIH, C3H and BALB/c mice were high responders to M. corti whereas CBA and 3 congenic strains sharing the B10 background (C57BL/10, B10.S, B10.G) were low responders. Some of the genes for high eosinophil responsiveness appeared to be dominant, as F1 hybrids from high and low response parental strains were intermediate to high in response to infection. SJL and NIH strains were highly susceptible to infection with M. corti, larval burdens at 21 days after infection with 100 tetrathyridia being considerably higher (greater than 1000) than all other strains. BALB/c (congruent to 700 larvae) were designated susceptible, SWR (greater than 400 larvae) were resistant and the B10 congenics (less than 400 larvae) were highly resistant. Genes influencing resistance also appeared to be dominant, as F1 hybrids between resistant and susceptible parental strains were intermediate to resistant on infection. The overall response patterns indicate a direct correlation between susceptibility to infection and high eosinophil responsiveness, but this relationship is not consistent in all strains.

show abstract

“…A number of mechanisms for the suppression of T. crassiceps in the presence of M. corti can be proposed including the involvement of the host's immune system, physical antagonism between the parasites, chemical repression and competition. Both M. corti and T. crassiceps interact with their host's immune systems (Kowalski & Thorson, 1972;. Thus, since both cestodes produce effective homologous immune responses, some form of crossreactivity might account for the observed suppression.…”

Section: Discussionmentioning

confidence: 99%

Suppression ofTaenia crassicepsduring concurrent infections withMesocestoides cortiin mice

1986

Parasitology

View full text Add to dashboard Cite

Parasite burden (by volume) was measured in female mice of three strains given single or concurrent infections of Mesocestoides corti and Taenia crassiceps. Significant suppression of T. crassiceps volume was observed over a range of M. corti inocula and occurred irrespective of whether M. corti was introduced before or after infection with T. crassiceps. Suppression of T. crassiceps volume was greatest with larger inocula of M. corti and with increased duration of M. corti infection. No significant difference was found in the intraperitoneal volume of M. corti from mice given single or simultaneous concurrent infections of M. corti and T. crassiceps. When M. corti were inoculated into mice with an established infection of T. crassiceps a significantly smaller volume of M. corti was retrieved at post-mortem from the peritoneal cavities of these mice, than from mice given just M. corti.

show abstract

Protective Immunity against Tetrathyridia of Mesocestoides corti by Passive Transfer of Serum in Mice

Cited by 16 publications

References 0 publications

The effect of the tetrathyridia of Mesocestoides corti on the livers and peripheral blood of three different strains of mice

The effect of the tetrathyridia of Mesocestoides corti on the livers and peripheral blood of three different strains of mice

Genetic influences upon eosinophilia and resistance in mice infected withMesocestoides corti

Suppression ofTaenia crassicepsduring concurrent infections withMesocestoides cortiin mice

Contact Info

Product

Resources

About