Protective levels of serum antibodies stimulated in infants by two injections of Haemophilus influenzae type b capsular polysaccharide-tetanus toxoid conjugate

Claesson, Bo A.; Schneerson, Rachel; Robbins, John B.; Johansson, Jan; Lagergård, Teresa; Taranger, J; Bryla, Dolores A.; Levi, Lily; Cramton, Tod; Trollfors, Birger

doi:10.1016/s0022-3476(89)80611-0

Cited by 79 publications

(21 citation statements)

References 11 publications

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“…The higher antibody rise among infants with a lower initial titre may reflect the influence of a passive inhibitory maternal antibody effect, although it could be a spurious result. This finding agrees with the observations of some authors in relation to Hib,7 diphtheria,8 9pertussis,8 10 tetanus7 and polio,8 but not those of others in relation to Hib 2. This effect is reduced, although not abolished, by dexamethasone.…”

Section: Discussionsupporting

confidence: 91%

Antibody response to accelerated Hib immunisation in preterm infants receiving dexamethasone for chronic lung disease

Robinson

Campbell

Powell

et al. 1999

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Aim-To study the eVect of dexamethasone on the routine immunisation of preterm infants with chronic lung disease. Methods-Serum samples were obtained before and after immunisation from an unselected cohort of 59 preterm infants. Haemophilus influenzae antibodies were measured using an ELISA method and diVerences in the geometric mean values between the two groups of babies analysed. Results-Sixteen infants received no dexamethasone. Before and after immunisation antibody titres for those receiving no dexamethasone were 0.16 and 4.63 mcg IgG/ml. Corresponding values for those receiving dexamethasone were 0.10 and 0.51 mcg IgG/ml, respectively. Conclusion-Dexamethasone used in the treatment of chronic lung disease seems to significantly aVect the antibody response of preterm infants to immunisation against Haemophilus influenzae. (Arch Dis Child Fetal Neonatal Ed 1999;80:F69-F71)

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Section: Discussionsupporting

confidence: 91%

Antibody response to accelerated Hib immunisation in preterm infants receiving dexamethasone for chronic lung disease

Robinson

Campbell

Powell

et al. 1999

Archives of Disease in Childhood - Fetal and Neonatal Edition

View full text Add to dashboard Cite

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“…Maternal immunization with conjugate against Haemophilus influenzae type b (Hib) before pregnancy has been shown to significantly increase the proportion of infants who had protective Hib Ab levels at birth and 2 months of age (54). Interference of MatAb with Hib vaccine responses has been reported (8). However, the persistence of protective Hib Abs without interference with the active Ab response has been shown in infants following combined passive and active immunization with high titers of bacterial PS immunoglobulins and Hib conjugate vaccine, also resulting in a dramatic decline in Hib disease (35,67).…”

Section: Discussionmentioning

confidence: 99%

Protective Levels of Polysaccharide-Specific Maternal Antibodies May Enhance the Immune Response Elicited by Pneumococcal Conjugates in Neonatal and Infant Mice

et al. 2005

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Maternal antibodies (MatAbs) may protect the offspring against infections but may also interfere with their immune responses to vaccination. We have previously shown that maternal immunization with pneumococcal polysaccharides (PPS) conjugated to tetanus protein (Pnc-TT) protected the offspring against infections caused by three important pediatric serotypes. To study the influence of MatAb on the immune response to Pnc-TT early in life, adult female mice were immunized twice with Pnc-TT of serotype 1 (Pnc1-TT), and their offspring received Pnc1-TT subcutaneously three times at 3-week intervals starting at 1 week (neonatal) or 3 weeks (infant) of age. High levels of PPS-1-specific MatAb (>3 log) in offspring of Pnc1-TT-immunized dams completely inhibited their anti-PPS-1 response elicited by Pnc1-TT. In contrast, low or moderate (ϳ1 to 2 log) levels of MatAb did not interfere with and even enhanced the immune response of the offspring, and a booster response to a second Pnc1-TT dose was observed. Carrier-specific MatAbs had little effect on the response of offspring to the conjugate. All Pnc1-TT-immunized offspring were protected against pneumococcal bacteremia and had reduced lung infection. These results demonstrate that in the presence of MatAb, Pnc1-TT may elicit a protective PPS-1-specific antibody response and prime for PPS-1-specific memory in young offspring. Importantly, low or moderate levels of PPS-1-specific MatAb not only provided protection against pneumococcal infections but also enhanced the immune response elicited by Pnc1-TT in neonatal and infant mice. This murine model will be used to develop novel strategies combining maternal and neonatal immunization to protect against infections caused by encapsulated bacteria in early life.

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“…Immunization of mothers during pregnancy could be especially attractive to provide protection of the newborn against infections caused by encapsulated bacteria, because infants do not readily respond to PS vaccines and antibody responses to PS tend to be short-lived (42). Interference of maternal antibodies in Haemophilus influenzae type b (Hib) vaccination has been reported (14). However, persistence of protective Hib antibodies without interference with the active antibody response has been shown in infants following passive-active immunization with high titers of bacterial PS immunoglobulins and Hib conjugate vaccine, also resulting in a dramatic decline in Hib disease (36,63).…”

Section: Discussionmentioning

confidence: 99%

Immunization of Female Mice with Glycoconjugates Protects Their Offspring against Encapsulated Bacteria

et al. 2004

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The immune system of the newborn is immature, and therefore it is difficult to induce protective immunity by vaccination in the neonatal period. Immunization of mothers during pregnancy against infections caused by encapsulated bacteria could thus be particularly attractive, as infants do not respond to polysaccharide (PS) antigens. Transmission of maternal vaccine-specific antibodies and protection of offspring against pneumococcal bacteremia and/or lung infection were studied in a neonatal murine model of pneumococcal immunization and infections. Adult female mice were immunized with native pneumococcal PS (PPS) of serotypes 1, 6B, and 19F or PPS conjugated to tetanus protein (Pnc-TT), and PPS-specific antibodies were measured in sera of mothers and their offspring. Effective transmission of maternal antibodies was observed, as PPS-specific immunoglobulin G levels in 3-week-old offspring of immunized mothers were 37 to 322% of maternal titers, and a significant correlation between maternal and offspring antibody levels was observed. The PPS-specific antibodies persisted for several weeks but slowly decreased over time. Offspring of Pnc-TT-immunized mothers were protected against pneumococcal infections with homologous serotypes, whereas PPS immunization of mothers did not protect their offspring, in agreement with the low titer of maternal PPS specific antibodies. When adult female mice were immunized with a meningococcal serogroup C conjugate vaccine (MenC-CRM), antibody response and transmission were similar to those observed for pneumococcal antibodies. Importantly, bactericidal activity was demonstrated in offspring of MenC-CRM-immunized mothers. These results demonstrate that this murine model of pneumococcal immunization and infections is suitable to study maternal immunization strategies for protection of offspring against encapsulated bacteria.

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Protective levels of serum antibodies stimulated in infants by two injections of Haemophilus influenzae type b capsular polysaccharide-tetanus toxoid conjugate

Cited by 79 publications

References 11 publications

Antibody response to accelerated Hib immunisation in preterm infants receiving dexamethasone for chronic lung disease

Antibody response to accelerated Hib immunisation in preterm infants receiving dexamethasone for chronic lung disease

Protective Levels of Polysaccharide-Specific Maternal Antibodies May Enhance the Immune Response Elicited by Pneumococcal Conjugates in Neonatal and Infant Mice

Immunization of Female Mice with Glycoconjugates Protects Their Offspring against Encapsulated Bacteria

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