Protective mechanism of fruit vinegar polyphenols against AGEs-induced Caco-2 cell damage

Wu, Qian; Kong, Yingfei; Liang, Yinggang; Niu, Mengyao; Feng, Nianjie; Zhang, Chan; Qi, Yonggang; Xiao, Juan; Zhou, Mengzhou; He, Yi; Wang, Chao

doi:10.1016/j.fochx.2023.100736

Cited by 12 publications

(6 citation statements)

References 47 publications

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“…Gallic acid is a phenolic antioxidant with multiple pharmacological activities, including antioxidant, antibacterial, antifungal, anti-inflammatory, photoprotective, anticarcinogenic, and antityrosinase [73]. Contrary to our study, in one study, catechin 159 × 10 −7 mg/mL was the most abundant phenolic component in watermelon vinegar [74]. As shown in Table 3, the relative content of polyphenols in 0-, 6-, 12-, and 24-month storage vinegar differed, but they all contained high gallic acid contents.…”

Section: Phenolic Compoundscontrasting

confidence: 96%

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Optimization of Ultrasound Treatment for Watermelon Vinegar Using Response Surface Methodology: Antidiabetic—Antihypertensive Effects, Bioactive Compounds, and Minerals

Tokatlı Demirok,

Yıkmış

2024

Fermentation

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Watermelon vinegar is a traditional fermented product with antioxidant activity. This study aimed to investigate the antihypertensive and antidiabetic properties of watermelon vinegar treated through ultrasound using the RSM method. We also evaluated the antioxidant activity (CUPRAC and DPPH), bioactive content (total phenolics and total flavonoids), mineral composition, phenolic compounds, α-glucosidase inhibition %, ACE inhibition %, of optimized, and α-amylase inhibition % during 24 months of storage of optimized watermelon vinegar. Optimized antidiabetic and antihypertensive activity was achieved at 6.7 min and 69% amplitude. The optimization of gallic acid was the dominant phenolic in the optimized ultrasound-treated watermelon vinegar (UT-WV) and showed a significant decrease during the 24 months of storage. The lycopene content of the UT-WV concentrate was 8.36 mg/100 mL, 8.30 mg/100 mL, 7.66 mg/100 mL, and 7.35 mg/100 mL after 0, 6, 2, and 24 months of storage, respectively. The levels of ACE inhibitory activity, α-glucosidase inhibitory activity, and α-amylase inhibitory activity decreased significantly (p < 0.05) after 24 months of storage. K, with values of 201.03 ± 28.31, was the main mineral in the UT-WV. Therefore, the bioactive components and the antidiabetic and antihypertensive properties of the UT-WV produced by conventional fermentation were necessary. Therefore, further experimental studies are necessary for a better understanding of the possible and potential health effects of watermelon vinegar.

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Section: Phenolic Compoundscontrasting

confidence: 96%

“…The TPC, TFC, and TAC results of the UT-WV samples under the storage conditions are shown in Figure 3. Feng et al (2023) reported that the total phenols were 203.05 ± 2.04 mg/mL and total flavonoids 7.49 ± 1.28 mg/mL in watermelon vinegar [14]. After 24 months of storage, the TPC values decreased significantly in the UT-WV.…”

Section: Bioactive Compoundsmentioning

confidence: 97%

Optimization of Ultrasound Treatment for Watermelon Vinegar Using Response Surface Methodology: Antidiabetic—Antihypertensive Effects, Bioactive Compounds, and Minerals

Tokatlı Demirok,

Yıkmış

2024

Fermentation

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“…86,87 In addition, AGEs promote macrophage polarization to a pro-inflammatory M1 phenotype and inhibit M2 polarization by regulating macrophage phenotypic reprogramming, which enhances MAPK signaling pathway and leads to β-cell dysfunction. 88,89 Lotus procyanidins can improve insulin resistance and diabetic complications by activating kinases such as ERK 1/2 and p38 MAPK and inhibiting the activation of NF-κB and JAK. 90 Moreover, they have beneficial effects on fatty acid-induced insulin resistance by inhibiting protein kinase C (PKC) activation and serine (Ser) 307 phosphorylation, thereby upregulating the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway and promoting glucose uptake.…”

Section: Improving Cognitive Memorymentioning

confidence: 99%

“…For example, the interaction between AGEs and the AGEs receptor (RAGE) activates the NF-κB pathway and promotes the expression of pro-inflammatory cytokines (TNF-α and IL-6) in podocytes, leading to podocyte hypertrophy, cell cycle arrest, and apoptosis, which leads to the development of diabetic nephropathy . Moreover, AGEs increase ROS production, impair mitochondrial function, reduce ATP production, and imbalance energy supply and demand in the body, thus inducing diabetes. , In addition, AGEs promote macrophage polarization to a pro-inflammatory M1 phenotype and inhibit M2 polarization by regulating macrophage phenotypic reprogramming, which enhances MAPK signaling pathway and leads to β-cell dysfunction. , Lotus procyanidins can improve insulin resistance and diabetic complications by activating kinases such as ERK 1/2 and p38 MAPK and inhibiting the activation of NF-κB and JAK . Moreover, they have beneficial effects on fatty acid-induced insulin resistance by inhibiting protein kinase C (PKC) activation and serine (Ser) 307 phosphorylation, thereby upregulating the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway and promoting glucose uptake.…”

Section: Functions Of Lotus Procyanidinsmentioning

confidence: 99%

Extraction Methods, Properties, Functions, and Interactions with Other Nutrients of Lotus Procyanidins: A Review

Wu,

Zhang,

Niu

et al. 2023

J. Agric. Food Chem.

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Lotus procyanidins, natural polyphenolic compounds isolated from the lotus plant family, are widely recognized as potent antioxidants that scavenge free radicals in the human body and exhibit various pharmacological effects, such as antiinflammatory, anticancer, antiobesity, and hypoglycemic. With promising applications in food and healthcare, lotus procyanidins have attracted extensive attention in recent years. This review provides a comprehensive summary of current research on lotus procyanidins, including extraction methods, properties, functions, and interactions with other nutrient components. Furthermore, this review offers an outlook on future research directions, providing ideas and references for the exploitation and utilization of lotus.

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“…Lotus seedpod oligomeric procyanidins (LSOPC) are extracted from lotus root waste after harvesting and are recognized as natural antioxidants with higher activity. − In a previous study, we demonstrated that LSOPC can effectively inhibit the production of AGEs during food processing. − At present, we investigated the ability of LSOPC to inhibit the absorption of the OLP-AGEs and analyzed the corresponding inhibitory mechanism.…”

Section: Introductionmentioning

confidence: 99%

Molecular Mechanism of Lotus Seedpod Oligomeric Procyanidins Inhibiting the Absorption of Oligopeptide-Advanced Glycation End Products

Kong

Feng

Liang

et al. 2023

J. Agric. Food Chem.

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Research on advanced glycation end product (AGEs) inhibition has generally focused on food processing, but many protein-AGEs will still be taken. Oligopeptide (OLP)-AGEs, as the main form after digestion, will damage human health once absorbed. Here, we investigated the ability of lotus seedpod oligomeric procyanidins (LSOPC) to inhibit the absorption of the OLP-AGEs and elucidated the underlying mechanism. Our results showed that the inhibition rate of LSOPC on the absorption of OLP-AGEs was about 50 ± 5.38%. 0.1, 0.2, and 0.3 mg/mL could upregulate the expression of ZO-1 and downregulate the expression of PepT1 and clathrin. Molecular docking showed that LSOPC could compete with the binding of OLP-AGEs to PepT1 and AP-2, thus inhibiting the absorption of OLP-AGEs. Furthermore, the interaction of LSOPC with the OLP-AGEs reduced the surface hydrophobicity of OLP-AGEs. It altered the secondary structure of the OLP-AGEs, thus weakening the affinity of the OLP-AGEs to the transporter protein to inhibit the absorption of OLP-AGEs. Together, our data revealed potential mechanisms by which LSOPC inhibit the absorption of OLP-AGEs and opened up new perspectives on the application of LSOPC in reducing the increasing health risks posed by OLP-AGEs.

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Protective mechanism of fruit vinegar polyphenols against AGEs-induced Caco-2 cell damage

Cited by 12 publications

References 47 publications

Optimization of Ultrasound Treatment for Watermelon Vinegar Using Response Surface Methodology: Antidiabetic—Antihypertensive Effects, Bioactive Compounds, and Minerals

Optimization of Ultrasound Treatment for Watermelon Vinegar Using Response Surface Methodology: Antidiabetic—Antihypertensive Effects, Bioactive Compounds, and Minerals

Extraction Methods, Properties, Functions, and Interactions with Other Nutrients of Lotus Procyanidins: A Review

Molecular Mechanism of Lotus Seedpod Oligomeric Procyanidins Inhibiting the Absorption of Oligopeptide-Advanced Glycation End Products

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